Annular Elastolytic Giant Cell Granuloma Associated with Temporal Arteritis Leading to Blindness

2011 ◽  
Vol 15 (5) ◽  
pp. 293-297 ◽  
Author(s):  
Ilya Shoimer ◽  
Judy Wismer
Keyword(s):  
Giant Cell ◽  
Temporal Arteritis ◽  
Case Reports ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Treatment Regimens ◽  
Steroid Dose ◽  
Granulomatous Disorder ◽  
The Right ◽  
Erythematous Plaques

Background: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous disorder characterized by giant cells in the dermis phagocytosing damaged elastin fragments. Objective: We report a case of a 71-year-old man presenting with erythematous plaques in predominantly sun-exposed areas. Method: A diagnosis of AEGCG was made based on the clinical and histologic picture, and treatment with systemic steroids was initiated. However, while tapering the steroid dose, the patient developed a radiating headache that progressed to temporal arteritis and eventual blindness in the right eye. Conclusion: There have been only two previous case reports presenting an association between AEGCG and temporal arteritis. This report explores AEGCG and its possible relationship to temporal arteritis along with possible treatment regimens cited in the current literature.

Giant Cell Granuloma of the Temporal Bone: A Case Report With Immunohistochemical, Enzyme Histochemical, and In Vitro Studies

2003 ◽  
Vol 127 (9) ◽  
pp. 1217-1220 ◽  
Author(s):  
Xue-Fei Tian ◽  
Tie-Jun Li ◽  
Shi-Feng Yu
Keyword(s):  
Giant Cell ◽  
Temporal Bone ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Tartrate Resistant Acid Phosphatase ◽  
Giant Cell Granuloma ◽  
Ki 67 ◽  
The Right ◽  
Histochemical Reactivity

Abstract A case of giant cell granuloma (GCG) that occurred in the right temporal bone is reported. The lesion showed histologic features identical to GCG. The multinuclear giant cells (MGCs) in the lesion showed strong reactivity with CD68, but patchy staining for myeloid/histiocyte antigen, α-1-antitrypsin, α-1-antichymotrypsine, and lysozyme. Activity of tartrate-resistant acid phosphatase was also consistently detected in the MGCs. Some of the mononuclear cells of the lesion exhibited similar immunocytochemical and histochemical reactivity as the MGCs. Ki-67 staining, however, was only detected in the mononuclear cells. The MGCs isolated from the lesion presented characteristic morphology of osteoclasts and possessed the ability to excavate bone in vitro. Thus, the MGCs in GCG appeared to express both macrophage- and osteoclast-associated phenotypes. The mononuclear cells were the major proliferative elements in the lesion and a subpopulation of these cells may represent precursors of the MGCs.

scholarly journals Clinical and surgical management of peripheral giant cell granuloma

2017 ◽  
Vol 19 (1) ◽  
Author(s):  
Patricia Vieyra Aranda ◽  
Patricia Trejos Quiroz ◽  
Claudia De León Torres ◽  
Daniela Carmona Ruiz
Keyword(s):  
Oral Cavity ◽  
Giant Cell ◽  
Surgical Management ◽  
Alveolar Bone ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Peripheral Giant Cell Granuloma ◽  
The Right

SUMMARYThe peripheral giant cell granuloma is anexophytic lesion developing in the oral cavity;it is one of the “reactive hyperplasias”The etiology is unknown In the literatureonly 12 cases have been reported in children,in these patients, it achieved rapidgrowth, behaving in an aggressive manneras it absorbed alveolar bone, leading totooth mobility and interferes with eruption.This article presents the case of a male 9years, 6 months old patient, who showeda red, soft, irregularly shaped gingivalswelling involving the right maxillarypremolars of 4cm in diameter with an ulcerin the oclusal side, asymptomatic and withshort evolution. Recurrence appeared inless than 6 months; histopathologic diagnosiswas peripheral giant cell granuloma,the treatment was surgical. The purpose ofthis study was to identify the peripheralgiant cell granuloma to avoid destructionof the alveolar bone, thus avoiding the lossof permanent teeth.Key words: Reactive hyperplasias, granuloma,giant cells.

Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones

2016 ◽  
Vol 8 (2) ◽  
pp. e12214 ◽  
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Shailesh Gawande ◽  
Snehal Patil ◽  
Rahul Anand ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Long Bones ◽  
Giant Cell Granuloma ◽  
Giant Cell Tumors ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals A UNIQUE CASE REPORT OF AGGRESSIVE CENTRAL GIANT CELL GRANULOMA OF THE MANDIBLE TREATED WITH CONSERVATIVE SURGICAL ENUCLEATION WITH LONG TERM FOLLOW-UP

2019 ◽  
Author(s):  
Gourab Das ◽  
Bharat Shukla ◽  
Dhritiman Pathak ◽  
Abhishek Singh ◽  
Shailesh Kumar
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Woven Bone ◽  
Long Term Follow Up ◽  
Benign Tumours ◽  
Bone Trabeculae ◽  
Surgical Aspects

Central Giant Cell Granuloma (CGCG) is an intrabony lesion showing cellular fibrosis with numerous foci of haemorrhage, woven bone trabeculae and multinucleated giant cells. It is more commonly found in the mandible than maxilla. Among all benign tumours of jaw, it accounts for less than 7%. According to the reports, in approximately 48% cases, it is diagnosed in the first two decades of life and in almost 60% cases, before 30 years of age. This paper presents a case of CGCG involving the mandibular left anterior region of a female patient with clinical, radiological, histopathological and surgical aspects of the lesion. Key Words- Central Giant Cell Granuloma (CGCG), CONSERVATIVE SURGICAL ENUCLEATION

scholarly journals Angiomyolipoma of the Oral Cavity: A Rare Case Report

2019 ◽  
pp. 107-110
Author(s):  
Sara Amanpour ◽  
Mohammad Reza Zarei ◽  
Javad Faryabi ◽  
Ahmad Ahrari
Keyword(s):  
Oral Cavity ◽  
Giant Cell ◽  
Case Reports ◽  
Thick Wall ◽  
Giant Cell Granuloma ◽  
First Case ◽  
Peripheral Giant Cell Granuloma ◽  
Rare Case Report ◽  
Rare Benign Tumor ◽  
Local Trauma

Angiomyolipoma (AML) is a rare, benign tumor composed of thick-wall blood vessels, smooth muscle component and mature adispose tissue. Differentiation from other benign and malignant mesenchymal lesions of oral cavity depends on recognition of these three histologic components, and immunohistochemical (IHC) techniques are also helpful. This tumor arise from perivascular epithelioid cells (PEComas) and kidneys followed by liver are the main locations of this soft tissue tumor. AMLs are rarely found in oral cavity and few case reports of oral AML have been reported in the literature. We report the first case of concurrent occurrence of AML of the tongue and peripheral giant cell granuloma of the gingiva in a 59-year-old patient. Clinically it was presented as a painless nodular mass with a smooth surface on the dorsal of the tongue. Based on histopathologic features and IHC staining the diagnosis of oral AML was done. The other lesion was a small sessile mass in interdental papillae of the lower incisors and microscopic examination showed the histologic features of a peripheral giant cell granuloma. Concurrent occurrence of PGCG which is a reactive mucosal hyperplasia and AML in our patient, could show the probable role of local trauma in the pathogenesis of these lesions.

scholarly journals Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

2016 ◽  
Vol 15 (3) ◽  
pp. 488-491
Author(s):  
Suchibrata Das ◽  
Joyeeta Chowdhury ◽  
Sangita Patra ◽  
Arun Achar
Keyword(s):  
Giant Cell ◽  
Cell Lymphoma ◽  
Medical Science ◽  
Giant Cells ◽  
Elastic Fibers ◽  
Cutaneous T Cell Lymphoma ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Systemic Involvement ◽  
Exposed Skin

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells. It is characterized by annular plaques that are similar to those observed in granuloma annulare but that specifically appear in sun-exposed skin and occurs more commonly in females than males. There have been reported cases of AEGCG associated with diabetes mellitus, systemic sarcoidosis, cutaneous amyloidosis, molluscum contagiosum, squamous cell carcinoma of the lung and cutaneous T-cell lymphoma. We report a case of AEGCG in both sun-exposed as well as covered areas of a middle aged lady with hepatic nodules and Barret’s esophagus.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.488-491

scholarly journals Central Giant Cell Granuloma

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Nilotpol Kashyap ◽  
Manisha Upadhyay ◽  
Rupam Tripathi ◽  
Pallavi Pawar ◽  
Ranjeet Kumar Prasad Sah ◽  
...  
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Benign Tumours ◽  
Health Organization ◽  
Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

Central Giant Cell Granuloma: A Narrative Review of Radiological Features and Differential Diagnosis

2020 ◽  
Vol 3 (2) ◽  
pp. 01-05
Author(s):  
Cinzia Casu
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Genetic Syndromes ◽  
Radiographic Appearance ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones ◽  
Aneurysmal Bone Cysts ◽  
Intraosseous Lesion

The Central Giant Cell Granuloma is an uncommon lesion, accounting less than 7% of all benign jaw lesions. In 1953, Jaffe was the first to describe these lesions as a giant cell reparative granuloma of the jaw bones, and in 1971, thanks to Pindborg and Kramer, it was included in the current nomenclature. The aetiology of CGCG is unknown, there is also a peripheral type that some authors consider the most common in maxillary bones. WHO defines CGCG as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells, and some trabeculae of woven bone. The radiographic appearance of CGCGs is not pathognomonic. CGCGs should be differentiated from other lesions of the jaws such as Brown’s tumour of hyperparathyroidism, fibrous dysplasia, aneurysmal bone cysts, giant cell tumours, fibro-osseous lesions, and other malignancies that arise in the jaw bones. Furthermore, it needs to be differentiated even from some genetic syndromes, such as Cherubism, type 1-neurofibromatosis and Noonan’s syndrome. The aim of this study is to focus on radiographic features of CGCG in order to achieve an appropriate tool for diagnosis.

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