scholarly journals Construction and characterization of rectal cancer‐related lncRNA‐mRNA ceRNA network reveals prognostic biomarkers in rectal cancer

2021 ◽  
Author(s):  
Guoying Cai ◽  
Meifei Sun ◽  
Xinrong Li ◽  
Junquan Zhu
Keyword(s):  
Rectal Cancer ◽  
Prognostic Biomarkers ◽  
Cerna Network

scholarly journals Development and Validation of a Nomogram and a Comprehensive Prognostic Analysis of an LncRNA-Associated Competitive Endogenous RNA Network Based on Immune-Related Genes for Locally Advanced Rectal Cancer With Neoadjuvant Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Fang-Ze Wei ◽  
Shi-Wen Mei ◽  
Zhi-Jie Wang ◽  
Jia-Nan Chen ◽  
Hai-Yu Shen ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Model ◽  
Cox Regression ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Prognostic Biomarkers ◽  
Comprehensive Treatment ◽  
Cerna Network

Colorectal cancer (CRC) is a common digestive tract tumor worldwide. In recent years, neoadjuvant chemoradiotherapy (CRT) has been the most comprehensive treatment for locally advanced rectal cancer (LARC). In this study, we explored immune infiltration in rectal cancer (RC) and identified immune-related differentially expressed genes (IRDEGs). Then, we identified response markers in datasets in GEO databases by principal component analysis (PCA). We also utilized three GEO datasets to identify the up- and downregulated response-related genes simultaneously and then identified genes shared between the PCA markers and three GEO datasets. Based on the hub IRDEGs, we identified target mRNAs and constructed a ceRNA network. Based on the ceRNA network, we explored prognostic biomarkers to develop a prognostic model for RC through Cox regression. We utilized the specimen to validate the expression of the two biomarkers. We also utilized LASSO regression to screen hub IRDEGs and built a nomogram to predict the response of LARC patients to CRT. All of the results show that the nomogram and prognostic model offer good prognostic value and that the ceRNA network can effectively highlight the regulatory relationship. hsa-mir-107 and WDFY3-AS2 may be prognostic biomarkers for RC.

Establishment and characterization of a rectal cancer model in mice: application to cytokine gene therapy

2002 ◽  
Vol 17 (6) ◽  
pp. 388-395 ◽  
Author(s):  
Yun Chen ◽  
King-Jen Chang ◽  
Lih-Hwa Hwang ◽  
Chiung-Nien Chen ◽  
Sheng-Hong Tseng
Keyword(s):  
Gene Therapy ◽  
Rectal Cancer ◽  
Cytokine Gene ◽  
Cancer Model ◽  
Cytokine Gene Therapy

scholarly journals Reply: Comment on ‘KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colo-rectal cancer’

2015 ◽  
Vol 113 (11) ◽  
pp. 1637-1638
Author(s):  
Stéphane Renaud ◽  
Pierre-Emmanuel Falcoz ◽  
Benoit Romain ◽  
Anne Olland ◽  
Nicola Santelmo ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Biomarkers ◽  
Braf Mutations ◽  
Lung Metastasectomy

Identifying prognostic biomarkers in endometrial carcinoma based on ceRNA network

2019 ◽  
Vol 121 (3) ◽  
pp. 2437-2446 ◽  
Author(s):  
Dongli Zhao ◽  
Chune Ren ◽  
Yan Yao ◽  
Qinjian Wang ◽  
Fei Li ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Prognostic Biomarkers ◽  
Cerna Network
Sign in / Sign up

Export Citation Format

Share Document