Electrochemical immunosensor for alpha‐fetoprotein based on prussian blue‐carbon nanotube@polydopamine

2018 ◽  
Vol 13 (1) ◽  
pp. 58-62 ◽  
Author(s):  
Ke Gao ◽  
Zhao Sun ◽  
Bo Guang Pan ◽  
Xiuwen Qiao ◽  
Chenglin Hong
Keyword(s):  
Carbon Nanotube ◽  
Prussian Blue ◽  
Electrochemical Immunosensor ◽  
Blue Carbon ◽  
Alpha Fetoprotein

Sensitive sandwich electrochemical immunosensor for alpha fetoprotein based on prussian blue modified hydroxyapatite

2011 ◽  
Vol 28 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Yuxue Dai ◽  
Yanyan Cai ◽  
Yanfang Zhao ◽  
Dan Wu ◽  
Bao Liu ◽  
...  
Keyword(s):  
Prussian Blue ◽  
Electrochemical Immunosensor ◽  
Alpha Fetoprotein

Polydopamine and graphene oxide synergistically modified Prussian blue electrochemical immunosensor for the detection of alpha-fetoprotein with enhanced stability and sensibility

RSC Advances ◽  
2015 ◽  
Vol 5 (48) ◽  
pp. 38176-38182 ◽  
Author(s):  
Ren-zhong Zhang ◽  
Bo-guang Pan ◽  
Hai-ning Wang ◽  
Jian-ming Dan ◽  
Cheng-lin Hong ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Prussian Blue ◽  
Electrochemical Immunosensor ◽  
Alpha Fetoprotein ◽  
Amperometric Immunosensor ◽  
Highly Sensitive ◽  
Enhanced Stability

In this paper, a simple and highly sensitive amperometric immunosensor for the determination of alpha-fetoprotein based on multi-functional gold nanoparticles–polydopamine-Prussian blue–graphene oxide nanocomposites (Au–PDA-PB–GO) was fabricated.

scholarly journals A Label and Probe-Free Zika Virus Immunosensor Prussian Blue@carbon Nanotube-Based for Amperometric Detection of the NS2B Protein

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 157
Author(s):  
Bárbara V. M. Silva ◽  
Marli T. Cordeiro ◽  
Marco A. B. Rodrigues ◽  
Ernesto T. A. Marques ◽  
Rosa F. Dutra
Keyword(s):  
Carbon Nanotube ◽  
Prussian Blue ◽  
Zika Virus ◽  
Point Of Care ◽  
Amperometric Detection ◽  
Cross Reactivity ◽  
Structural Protein ◽  
Serum Samples ◽  
Polypyrrole Composite ◽  
Congenital Disabilities

Zika virus (ZIKV) is a mosquito-borne infection, predominant in tropical and subtropical regions causing international concern due to the ZIKV disease having been associated with congenital disabilities, especially microcephaly and other congenital abnormalities in the fetus and newborns. Development of strategies that minimize the devastating impact by monitoring and preventing ZIKV transmission through sexual intercourse, especially in pregnant women, since no vaccine is yet available for the prevention or treatment, is critically important. ZIKV infection is generally asymptomatic and cross-reactivity with dengue virus (DENV) is a global concern. An innovative screen-printed electrode (SPE) was developed for amperometric detection of the non-structural protein (NS2B) of ZIKV by exploring the intrinsic redox catalytic activity of Prussian blue (PB), incorporated into a carbon nanotube–polypyrrole composite. Thus, this immunosensor has the advantage of electrochemical detection without adding any redox-probe solution (probe-less detection), allowing a point-of-care diagnosis. It was responsive to serum samples of only ZIKV positive patients and non-responsive to negative ZIKV patients, even if the sample was DENV positive, indicating a possible differential diagnosis between them by NS2B. All samples used here were confirmed by CDC protocols, and immunosensor responses were also checked in the supernatant of C6/36 and in Vero cell cultures infected with ZIKV.

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