Novel Approaches to Photon Detection and Timing for 7-Wavelength Time Domain Optical Mammography

2017 ◽  
Author(s):  
E. Ferocino ◽  
E. Martinenghi ◽  
A. Dalla Mora ◽  
A. Pifferi ◽  
R. Cubeddu ◽  
...  
Keyword(s):  
Time Domain ◽  
Photon Detection ◽  
Optical Mammography ◽  
Novel Approaches

scholarly journals Single-Photon Detection Module Based on Large-Area Silicon Photomultipliers for Time-Domain Diffuse Optics

Instruments ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 18
Author(s):  
Fabio Acerbi ◽  
Anurag Behera ◽  
Alberto Dalla Mora ◽  
Laura Di Sieno ◽  
Alberto Gola
Keyword(s):  
Time Resolution ◽  
Time Domain ◽  
Single Photon ◽  
Building Blocks ◽  
The Body ◽  
Single Photon Detection ◽  
Silicon Photomultipliers ◽  
Photon Detection ◽  
Instrument Response Function ◽  
Diffuse Optics

Silicon photomultipliers (SiPM) are pixelated single-photon detectors combining high sensitivity, good time resolution and high dynamic range. They are emerging in many fields, such as time-domain diffuse optics (TD-DO). This is a promising technique in neurology, oncology, and quality assessment of food, wood, and pharmaceuticals. SiPMs can have very large areas and can significantly increase the sensitivity of TD-DO in tissue investigation. However, such improvement is currently limited by the high detector noise and the worsening of SiPM single-photon time resolution due to the large parasitic capacitances. To overcome such limitation, in this paper, we present two single-photon detection modules, based on 6 × 6 mm2 and 10 × 10 mm2 SiPMs, housed in vacuum-sealed TO packages, cooled to −15 °C and −36 °C, respectively. They integrate front-end amplifiers and temperature controllers, being very useful instruments for TD-DO and other biological and physical applications. The signal extraction from the SiPM was improved. The noise is reduced by more than two orders of magnitude compared to the room temperature level. The full suitability of the proposed detectors for TD-DO measurements is outside the scope of this work, but preliminary tests were performed analyzing the shape and the stability of the Instrument Response Function. The proposed modules are thus fundamental building blocks to push the TD-DO towards deeper investigations inside the body.

Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients

2005 ◽  
Vol 50 (11) ◽  
pp. 2429-2449 ◽  
Author(s):  
Dirk Grosenick ◽  
K Thomas Moesta ◽  
Michael Möller ◽  
Jörg Mucke ◽  
Heidrun Wabnitz ◽  
...  
Keyword(s):  
Time Domain ◽  
Optical Mammography

Optical mammography in the time domain up to 1060 nm: from tests on healthy women to initial data for monitoring neoadjuvant chemotherapy

2021 ◽  
Author(s):  
Giulia Maffeis ◽  
Edoardo Ferocino ◽  
Alberto Dalla Mora ◽  
Rinaldo Cubeddu ◽  
Antonio Pifferi ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Initial Data ◽  
Time Domain ◽  
Optical Mammography ◽  
Healthy Women ◽  
The Time Domain

Time-domain optical mammography: results on phantoms, healthy volunteers, and patients

1998 ◽  
Author(s):  
H. Rinneberg ◽  
D. Grosenick ◽  
H. Wabnitz ◽  
H. Danlewski ◽  
K. Moesta ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Time Domain ◽  
Optical Mammography

An efficient Jacobian scaling method for time-domain optical mammography

2010 ◽  
Vol 8 (2) ◽  
pp. 206-209
Author(s):  
马艺闻 Yiwen Ma ◽  
高峰 Feng Gao ◽  
阮平巧 Pingqiao Ruan ◽  
杨芳 Fang Yang ◽  
赵会娟 Huijuan Zhao
Keyword(s):  
Time Domain ◽  
Scaling Method ◽  
Optical Mammography

Time-Domain Optical Mammography SoftScan: Initial Results

2005 ◽  
Vol 12 (10) ◽  
pp. 1355
Author(s):  
Xavier Intes ◽  
Salim Djeziri ◽  
Zahia Ichalalene ◽  
Niculae Mincu ◽  
Yong Wang ◽  
...  
Keyword(s):  
Time Domain ◽  
Optical Mammography ◽  
Initial Results

Time-Domain Optical Mammography SoftScan

2005 ◽  
Vol 12 (8) ◽  
pp. 934-947 ◽  
Author(s):  
Xavier Intes
Keyword(s):  
Time Domain ◽  
Optical Mammography

Enhancing time-domain optical mammography by relocating optodes

2009 ◽  
Author(s):  
Yiwen Ma ◽  
Jingyi Wang ◽  
Feng Gao ◽  
Fang Yang ◽  
Huijuan Zhao ◽  
...  
Keyword(s):  
Time Domain ◽  
Optical Mammography

Scanning Time-domain Optical Mammography: Detection and Characterization of Breast Tumors In Vivo

2005 ◽  
Vol 4 (5) ◽  
pp. 483-496 ◽  
Author(s):  
Herbert Rinneberg ◽  
Dirk Grosenick ◽  
K. Thomas Moesta ◽  
Jörg Mucke ◽  
Bernd Gebauer ◽  
...  
Keyword(s):  
Time Domain ◽  
Near Infrared ◽  
Strong Light ◽  
New Techniques ◽  
Optical Mammography ◽  
Scanning Time ◽  
Nir Light ◽  
Tissue Scattering

Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to near infrared (NIR) light dominates absorption and NIR light may penetrate several centimeters through the breast. Optical mammography avoids the use of ionizing radiation and offers the power of diffuse optical spectroscopy. However, because of strong light scattering, spatial resolution of optical mammography is generally low. The paper reviews the results of a clinical study on scanning time-domain optical mammography comprising 154 patients carrying a total of 102 carcinomas validated by histology. Ninety two of these tumors were detected in optical mammograms retrospectively and for 87 of the detected tumors optical properties and tissue parameters were derived. In addition developments on instrumentation and data analysis are covered and possible improvements of optical mammography are briefly discussed.

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