scholarly journals Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids

2021 ◽  
Author(s):  
Simona Radice ◽  
Gretchen Tibbits ◽  
Alex Y. W. Lin ◽  
Haluk Beyenal ◽  
Markus A. Wimmer
Keyword(s):  
Hyaluronic Acid ◽  
Alloy Surface ◽  
Cocrmo Alloy ◽  
Synovial Fluids

scholarly journals Analysis of Chemisorbed Tribo-Film for Ceramic-on-Ceramic Hip Joint Prostheses by Raman Spectroscopy

2021 ◽  
Vol 12 (2) ◽  
pp. 29
Author(s):  
Risha Rufaqua ◽  
Martin Vrbka ◽  
Dušan Hemzal ◽  
Dipankar Choudhury ◽  
David Rebenda ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Hyaluronic Acid ◽  
Hip Joint ◽  
Total Joint Replacement ◽  
Film Formation ◽  
Frictional Coefficient ◽  
Synovial Fluids ◽  
Frictional Coefficients ◽  
Joint Prostheses ◽  
Ceramic On Ceramic

To understand the possible lubricant mechanism in ceramic-on-ceramic hip joint prostheses, biochemical reactions of the synovial fluid and the corresponding frictional coefficients were studied. The experiments were performed in a hip joint simulator using the ball-on-cup configuration with balls and cups made from two types of ceramics, BIOLOX®forte and BIOLOX®delta. Different lubricants, namely albumin, γ-globulin, hyaluronic acid and three model synovial fluids, were studied in the experiments and Raman spectroscopy was used to analyze the biochemical responses of these lubricants at the interface. BIOLOX®delta surface was found less reactive to proteins and model fluid lubricants. In contrast, BIOLOX®forte ball surface has shown chemisorption with both proteins, hyaluronic acid and model fluids imitating total joint replacement and osteoarthritic joint. There was no direct correlation between the measured frictional coefficient and the observed chemical reactions. In summary, the study reveals chemistry of lubricant film formation on ceramic hip implant surfaces with various model synovial fluids and their components.

Inflammatory and Noninflammatory Synovial Fluids Exhibit New and Distinct Tribological Endotypes

2020 ◽  
Vol 142 (11) ◽  
Author(s):  
Elizabeth Feeney ◽  
Devis Galesso ◽  
Cynthia Secchieri ◽  
Francesca Oliviero ◽  
Roberta Ramonda ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Inflammatory Arthritis ◽  
Tribological Behavior ◽  
Friction Coefficients ◽  
Low Concentrations ◽  
Synovial Fluids ◽  
Erratic Behavior ◽  
Lubricating Properties

Abstract Inferior synovial lubrication is a hallmark of osteoarthritis (OA), and synovial fluid (SF) lubrication and composition are variable among OA patients. Hyaluronic acid (HA) viscosupplementation is a widely used therapy for improving SF viscoelasticity and lubrication, but it is unclear how the effectiveness of HA viscosupplements varies with arthritic endotype. The objective of this study was to investigate the effects of the HA viscosupplement, Hymovis®, on the lubricating properties of diseased SF from patients with noninflammatory OA and inflammatory arthritis (IA). The composition (cytokine, HA, and lubricin concentrations) of the SF was measured as well as the mechanical properties (rheology, tribology) of the SF alone and in a 1:1 mixture with the HA viscosupplement. Using rotational rheometry, no difference in SF viscosity was detected between disease types, and the addition of HA significantly increased all fluids' viscosities. In noninflammatory OA SF, friction coefficients followed a typical Stribeck pattern, and their magnitude was decreased by the addition of HA. While some of the IA SF also showed typical Stribeck behavior, a subset showed more erratic behavior with highly variable and larger friction coefficients. Interestingly, this aberrant behavior was not eliminated by the addition of HA, and it was associated with low concentrations of lubricin. Aberrant SF exhibited significantly lower effective viscosities compared to noninflammatory OA and IA SF with typical tribological behavior. Collectively, these results suggest that different endotypes of arthritis exist with respect to lubrication, which may impact the effectiveness of HA viscosupplements in reducing friction.

The role of protein content on the steady and oscillatory shear rheology of model synovial fluids

Soft Matter ◽  
2014 ◽  
Vol 10 (32) ◽  
pp. 5965-5973 ◽  
Author(s):  
Z. Zhang ◽  
S. Barman ◽  
G. F. Christopher
Keyword(s):  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Acid Solution ◽  
Protein Content ◽  
Shear Viscosity ◽  
Steady Shear ◽  
Interfacial Rheology ◽  
Steady Shear Viscosity ◽  
Synovial Fluids

Model synovial fluid steady shear viscosity to hyaluronic acid solution are identical when interfacial rheology effects are removed.

LUBRICATING CHARACTERISTICS OF HYALURONIC ACID MOLECULES ON THE ALBUMIN-MEDIATED TRIBOLOGICAL PROCESSES

2012 ◽  
Vol 24 (06) ◽  
pp. 557-562
Author(s):  
Huei-Ting Huang ◽  
Hsu-Wei Fang
Keyword(s):  
Hyaluronic Acid ◽  
Friction Coefficient ◽  
Synovial Fluid ◽  
Concentration Level ◽  
Artificial Joint ◽  
Cocrmo Alloy ◽  
Wear Process ◽  
Lubricating Layer ◽  
Lubrication Conditions ◽  
Lubricating Mechanism

Synovial fluid mediated boundary lubrication is the key mechanism dominating the wear process of the artificial joint materials. The most abundant composition in the synovial fluid is albumin. It has been observed that the increasing human serum albumin (HSA) concentration leads to the increasing friction coefficient under the articulation of ultra-high molecular polyethylene (UHMWPE) and CoCrMo alloy materials. In this study, the friction and adsorption experiments were carried out to investigate the effects from addition of hyaluronic acid (HA) molecules. Our results indicated that the increase in HA concentration level results in the decrease of the frictions under HSA-HA mixed lubrication conditions. Insertion of HA molecules at the interface provide a higher elasticity of the lubricating layer. This "damping" mode results in the slightly reduction of friction. More HA molecules may entrap the HSA molecules and then expel them away from the articulating surfaces. This "expelling" mode leads to a significant decrease of friction. The lubricating mechanism of hyaluronic acid on the albumin-mediated tribological processes between UHMWPE and CoCrMo materials was investigated and proposed in this study.

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