Feasibility of global miRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib

2014 ◽  
Vol 128 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Jan Peveling-Oberhag ◽  
Claudia Döring ◽  
Sylvia Hartmann ◽  
Natalie Filmann ◽  
Angelika Mertens ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mirna Expression ◽  
Needle Biopsy ◽  
Response Prediction ◽  
Fine Needle Biopsy ◽  
Fine Needle ◽  
Biopsy Specimens ◽  
Sorafenib Therapy ◽  
Ffpe Material

The present study demonstrates that miRNA analyses are feasible from fine-needle biopsy specimens and is the first to correlate the response under sorafenib therapy to miRNA expression signatures in hepatocellular carcinoma (HCC). The data do not support that miRNA profiles function as reliable biomarkers for sorafenib response prediction.

scholarly journals Macroscopic on-site evaluation of biopsy specimens for accurate pathological diagnosis during EUS-guided fine needle biopsy using 22-G Franseen needle

2020 ◽  
Vol 9 (6) ◽  
pp. 385
Author(s):  
Hirotoshi Ishiwatari ◽  
Junichi Kaneko ◽  
Keiko Sasaki ◽  
Tatsunori Satoh ◽  
Junya Sato ◽  
...  
Keyword(s):  
Needle Biopsy ◽  
Fine Needle Biopsy ◽  
Pathological Diagnosis ◽  
Fine Needle ◽  
Biopsy Specimens ◽  
Site Evaluation

scholarly journals Targeted DNA and RNA sequencing of fine-needle biopsy FFPE specimens in patients with unresectable hepatocellular carcinoma treated with sorafenib

Oncotarget ◽  
2015 ◽  
Vol 6 (25) ◽  
pp. 21636-21644 ◽  
Author(s):  
Kazuko Sakai ◽  
Haruhiko Takeda ◽  
Norihiro Nishijima ◽  
Etsuro Orito ◽  
Kouji Joko ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rna Sequencing ◽  
Needle Biopsy ◽  
Fine Needle Biopsy ◽  
Fine Needle ◽  
Dna And Rna ◽  
Unresectable Hepatocellular Carcinoma

Percutaneous Interstitial Chemotherapy of a Small Hepatocellular Carcinoma under Ultrasound Guidance

1986 ◽  
Vol 72 (5) ◽  
pp. 525-527 ◽  
Author(s):  
Tito Livraghi ◽  
Carlo Ravetto ◽  
Luigi Solbiati ◽  
Fredy Suter
Keyword(s):  
Hepatocellular Carcinoma ◽  
Alternative Treatment ◽  
Needle Biopsy ◽  
Ultrasound Guidance ◽  
Fine Needle Biopsy ◽  
Small Hepatocellular Carcinoma ◽  
Fine Needle ◽  
Interstitial Chemotherapy ◽  
Interesting Alternative

A small < 3 cm) inoperable hepatocellular carcinoma was treated with percutaneous interstitial chemotherapy (PIC). 5-Fluorouracil was injected by a fine needle under ultrasound guidance. After 3 months a fine needle biopsy (FNB) yielded fibronecrotic material. After 18 months another FNB yielded steatosis and dysplastic cells and the lesion showed no increase in size. PIC could be an interesting alternative treatment for small tumors unresponsive to conventional therapies.

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