Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis

2014 ◽  
Vol 126 (9) ◽  
pp. 633-644 ◽  
Author(s):  
Shao-Jung Hsu ◽  
Sun-Sang Wang ◽  
I-Fang Hsin ◽  
Fa-Yauh Lee ◽  
Hui-Chun Huang ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Green Tea ◽  
Tea Polyphenol ◽  
Akt Activation ◽  
Green Tea Polyphenol ◽  
Portosystemic Shunting ◽  
Portosystemic Collaterals

Green tea polyphenol ameliorates the severity of portosystemic shunting and mesenteric angiogenesis via the suppression of HIF-1α, Akt activation and VEGF. Green tea polyphenol appears to be an appropriate agent to control portal hypertension-related complications via anti-angiogenenic effects.

scholarly journals Glucobrassicin Metabolites Ameliorate the Development of Portal Hypertension and Cirrhosis in Bile Duct-Ligated Rats

2019 ◽  
Vol 20 (17) ◽  
pp. 4161
Author(s):  
Ting Chang ◽  
Hsin-Ling Ho ◽  
Shao-Jung Hsu ◽  
Ching-Chih Chang ◽  
Ming-Hung Tsai ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Bile Duct ◽  
Portal Pressure ◽  
Sham Operation ◽  
Duct Ligation ◽  
Phosphorylated Akt ◽  
Protein Expressions ◽  
Portosystemic Shunting ◽  
Portosystemic Collaterals

Patients suffering from liver cirrhosis are often complicated with the formation of portosystemic collateral vessels, which is associated with the progression of a splanchnic hyperdynamic circulatory state. Alleviating pathological angiogenesis has thus been proposed to be a feasible treatment strategy. Indole-3-carbinol (C9H9NO, I3C) and 3,3′-diindolymethane (DIM), formed by the breakdown of glucosinolate glucobrassicin, are prevalent in cruciferous vegetables and have anti-angiogenesis properties. We aimed to evaluate their influences on portal hypertension, the severity of mesenteric angiogenesis, and portosystemic collaterals in cirrhosis. Sprague-Dawley rats with common bile duct ligation (CBDL)-induced liver cirrhosis or sham operation (surgical control) were randomly allocated to receive I3C (20 mg/kg/3 day), DIM (5 mg/kg/day) or vehicle for 28 days. The systemic and portal hemodynamics, severity of portosystemic shunting, mesenteric angiogenesis, and mesenteric proangiogenic factors protein expressions were evaluated. Compared to vehicle, both DIM and I3C significantly reduced portal pressure, ameliorated liver fibrosis, and down-regulated mesenteric protein expressions of vascular endothelial growth factor and phosphorylated Akt. DIM significantly down-regulated pErk, and I3C down-regulated NFκB, pIκBα protein expressions, and reduced portosystemic shunting degree. The cruciferous vegetable byproducts I3C and DIM not only exerted a portal hypotensive effect but also ameliorated abnormal angiogenesis and portosystemic collaterals in cirrhotic rats.

Green Tea Polyphenol Extract Regulates the Expression of Genes Involved in Glucose Uptake and Insulin Signaling in Rats Fed a High Fructose Diet

2007 ◽  
Vol 55 (15) ◽  
pp. 6372-6378 ◽  
Author(s):  
Heping Cao ◽  
Isabelle Hininger-Favier ◽  
Meghan A. Kelly ◽  
Rachida Benaraba ◽  
Harry D. Dawson ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Green Tea ◽  
Insulin Signaling ◽  
Tea Polyphenol ◽  
High Fructose Diet ◽  
Expression Of Genes ◽  
High Fructose ◽  
Green Tea Polyphenol

New Insights into Anticancer Effect of Green Tea Polyphenol Epigallocatechin-3-gallate in Hypoxia by Metabolic Profiling

2010 ◽  
Vol 49 ◽  
pp. S220
Author(s):  
Yoshinori Fujimura ◽  
Shuntaro Tsukamoto ◽  
Miho Irie ◽  
Daisuke Miura ◽  
Hiroyuki Miura ◽  
...  
Keyword(s):  
Green Tea ◽  
Metabolic Profiling ◽  
Tea Polyphenol ◽  
Anticancer Effect ◽  
Green Tea Polyphenol

Green Tea Polyphenol-Stabilized Gel-Like High Internal Phase Pickering Emulsions

2021 ◽  
Vol 9 (11) ◽  
pp. 4076-4090
Author(s):  
Qiulan Tong ◽  
Zeng Yi ◽  
Yaqin Ran ◽  
Xiangyu Chen ◽  
Guangcan Chen ◽  
...  
Keyword(s):  
Green Tea ◽  
Pickering Emulsions ◽  
Tea Polyphenol ◽  
Internal Phase ◽  
Green Tea Polyphenol

The Acid-Promoted Reaction of the Green Tea Polyphenol Epigallocatechin Gallate with Nitrite Ions

2005 ◽  
Vol 18 (4) ◽  
pp. 722-729 ◽  
Author(s):  
Lucia Panzella ◽  
Paola Manini ◽  
Alessandra Napolitano ◽  
Marco d'Ischia
Keyword(s):  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol
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