Green Tea Polyphenol Extract Regulates the Expression of Genes Involved in Glucose Uptake and Insulin Signaling in Rats Fed a High Fructose Diet

2007 ◽  
Vol 55 (15) ◽  
pp. 6372-6378 ◽  
Author(s):  
Heping Cao ◽  
Isabelle Hininger-Favier ◽  
Meghan A. Kelly ◽  
Rachida Benaraba ◽  
Harry D. Dawson ◽  
...  
2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mehmet Bilgehan Pektas ◽  
Halit Bugra Koca ◽  
Gokhan Sadi ◽  
Fatma Akar

The effects of high-fructose diet on adipose tissue insulin signaling and inflammatory process have been poorly documented. In this study, we examined the influences of long-term fructose intake and resveratrol supplementation on the expression of genes involved in insulin signaling and the levels of inflammatory cytokines and sex hormones in the white adipose tissues of male and female rats. Consumption of high-fructose diet for 24 weeks increased the expression of genes involved in insulin signaling includingIR,IRS-1,IRS-2,Akt,PI3K,eNOS,mTOR, andPPARγ, despite induction of proinflammatory markers, iNOS, TNFα, IL-1β, IL-18, MDA, and ALT, as well as anti-inflammatory factors, IL-10 and Nrf2 in adipose tissues from males and females. Total and free testosterone concentrations of adipose tissues were impaired in males but increased in females, although there were no changes in their blood levels. Resveratrol supplementation markedly restored the levels of MDA, IL6, IL-10, and IL-18, as well asiNOS,Nrf2, andPI3KmRNA, in adipose tissues of both genders. Dietary fructose activates both insulin signaling and inflammatory pathway in the adipose tissues of male and female rats proposing no correlation between the tissue insulin signaling and inflammation. Resveratrol has partly modulatory effects on fructose-induced changes.


2010 ◽  
Vol 49 ◽  
pp. S220
Author(s):  
Yoshinori Fujimura ◽  
Shuntaro Tsukamoto ◽  
Miho Irie ◽  
Daisuke Miura ◽  
Hiroyuki Miura ◽  
...  

2021 ◽  
Vol 9 (11) ◽  
pp. 4076-4090
Author(s):  
Qiulan Tong ◽  
Zeng Yi ◽  
Yaqin Ran ◽  
Xiangyu Chen ◽  
Guangcan Chen ◽  
...  

2005 ◽  
Vol 18 (4) ◽  
pp. 722-729 ◽  
Author(s):  
Lucia Panzella ◽  
Paola Manini ◽  
Alessandra Napolitano ◽  
Marco d'Ischia

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