Impaired cardiovascular responses to baroreflex stimulation in open-angle and normal-pressure glaucoma

2002 ◽  
Vol 102 (6) ◽  
pp. 623 ◽  
Author(s):  
Clive M. BROWN ◽  
Matthias DÜTSCH ◽  
Georg MICHELSON ◽  
Bernhard NEUNDRFER ◽  
Max J. HILZ
Keyword(s):  
Cardiovascular Responses ◽  
Normal Pressure ◽  
Open Angle ◽  
Normal Pressure Glaucoma ◽  
Baroreflex Stimulation

Impaired cardiovascular responses to baroreflex stimulation in open-angle and normal-pressure glaucoma

2002 ◽  
Vol 102 (6) ◽  
pp. 623-630 ◽  
Author(s):  
Clive M. BROWN ◽  
Matthias DÜTSCH ◽  
Georg MICHELSON ◽  
Bernhard NEUNDÖRFER ◽  
Max J. HILZ
Keyword(s):  
Blood Vessels ◽  
Open Angle Glaucoma ◽  
Cardiovascular Responses ◽  
Normal Pressure ◽  
Control Group ◽  
Open Angle ◽  
Baroreflex Control ◽  
Rr Interval ◽  
Normal Pressure Glaucoma ◽  
Interval Response

Autonomic neuropathy may contribute to the pathophysiology of both open-angle and normal-pressure glaucoma. However, autonomic function has not been studied extensively in these diseases. We evaluated baroreflex control of the heart and blood vessels in open-angle and normal-pressure glaucoma. We studied 14 patients with open-angle glaucoma, 15 with normal-pressure glaucoma and 17 controls. Sinusoidal neck suction (0 to -30mmHg) was applied at 0.1Hz to assess the sympathetic modulation of the heart and blood vessels, and at 0.2Hz to assess the effect of parasympathetic stimulation on the heart. Baseline recordings showed no significant differences between the groups. The RR-interval response of the controls to neck suction at 0.1Hz (3.88±0.32 to 6.65±0.44lnms2) was significantly greater than that of the open-angle glaucoma patients (4.22±0.28 to 5.56±0.26lnms2) and the normal-pressure glaucoma patients (4.53±0.27 to 5.53±0.37lnms2) (P<0.05). The low-frequency power of diastolic blood pressure increased significantly in the controls (0.48±0.08 to 2.76±0.72mmHg2; P<0.01) during 0.1Hz neck suction, but did not change significantly in patients with either open-angle glaucoma or normal-pressure glaucoma. The RR-interval response in the control group (3.45±0.52lnms2) to neck suction at 0.2Hz was significantly greater than that of the normal-pressure glaucoma patients (1.84±0.32lnms2) and the open-angle glaucoma patients (1.58±0.35lnms2) (P<0.05). The decreased sympathetic and parasympathetic modulation during baroreceptor stimulation in patients with open-angle glaucoma and normal-pressure glaucoma suggests that autonomic dysfunction may contribute to the pathogenesis of both diseases.

scholarly journals Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

2014 ◽  
Vol 133 (10) ◽  
pp. 1319-1330 ◽  
Author(s):  
Jessica N. Cooke Bailey ◽  
Brian L. Yaspan ◽  
Louis R. Pasquale ◽  
Michael A. Hauser ◽  
Jae H. Kang ◽  
...  
Keyword(s):  
Pathway Analysis ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Normal Pressure ◽  
Open Angle ◽  
Acetyl Coa ◽  
Normal Pressure Glaucoma

scholarly journals Comparison of T Helper Cell Patterns in Primary Open-Angle Glaucoma and Normal-Pressure Glaucoma

2018 ◽  
Vol 24 ◽  
pp. 1988-1996 ◽  
Author(s):  
Chunyu Guo ◽  
Ningbo Wu ◽  
Xiaoyin Niu ◽  
Yue Wu ◽  
Dongfeng Chen ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Normal Pressure ◽  
T Helper Cell ◽  
Helper Cell ◽  
Open Angle ◽  
T Helper ◽  
Cell Patterns ◽  
Normal Pressure Glaucoma

scholarly journals Ocular haemodynamics in some subgroups of normal pressure glaucoma

2009 ◽  
Vol 75 (S224) ◽  
pp. 35-36 ◽  
Author(s):  
F. Galassi ◽  
A. Sodi ◽  
M. G. Rossi ◽  
F. Ucci ◽  
F. Pierre
Keyword(s):  
Normal Pressure ◽  
Normal Pressure Glaucoma

scholarly journals Anterior visual pathway assessment by magnetic resonance imaging in normal-pressure glaucoma

2012 ◽  
Vol 90 (4) ◽  
pp. e295-e302 ◽  
Author(s):  
Ya Q. Zhang ◽  
Jing Li ◽  
Liang Xu ◽  
Li Zhang ◽  
Zhen C. Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Normal Pressure ◽  
Visual Pathway ◽  
Resonance Imaging ◽  
Normal Pressure Glaucoma
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