Blood pressure and renal haemodynamic response to salt during the normal menstrual cycle

2000 ◽  
Vol 98 (6) ◽  
pp. 697 ◽  
Author(s):  
Antoinette PECHÈRE-BERTSCHI ◽  
Marc MAILLARD ◽  
Hans STALDER ◽  
Hans R. BRUNNER ◽  
Michel BURNIER
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Haemodynamic Response ◽  
Normal Menstrual Cycle

Blood pressure and renal haemodynamic response to salt during the normal menstrual cycle

2000 ◽  
Vol 98 (6) ◽  
pp. 697-702 ◽  
Author(s):  
Antoinette PECHÈRE-BERTSCHI ◽  
Marc MAILLARD ◽  
Hans STALDER ◽  
Hans R. BRUNNER ◽  
Michel BURNIER
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Blood Pressure Response ◽  
Follicular Phase ◽  
Pressure Response ◽  
Renal Haemodynamics ◽  
Haemodynamic Response ◽  
Salt Loading ◽  
Normal Menstrual Cycle

The purpose of the present study was to evaluate prospectively blood pressure and the renal haemodynamic response to salt during the normal menstrual cycle. A total of 35 healthy normotensive young women not on oral contraceptives were enrolled; 17 were studied in the follicular phase and 18 in the luteal phase of the menstrual cycle. The women in each group were then randomly allocated to receive a low-sodium (40 mmol/day) or a high-sodium (250 mmol/day) diet for a 7-day period in two consecutive menstrual cycles. At the end of each dietary period, 24 h ambulatory blood pressure, urinary sodium excretion, plasma renin activity, plasma catecholamine levels and renal haemodynamics were measured. Our results show that the blood pressure response to salt is comparable during the luteal and the follicular phases of the normal menstrual cycle and is characterized by a salt-resistant pattern. In the kidney, effective renal plasma flow was significantly greater and the filtration fraction lower (P < 0.05) after salt loading in women studied in the luteal phase compared with women investigated in the follicular phase. This study thus demonstrates that the female hormone status does not affect the blood pressure response to sodium in young normotensive women. However, in contrast with systemic haemodynamics, the renal response to salt varies during the normal menstrual cycle, suggesting that female sex hormones play a role (direct or indirect) in the regulation of renal haemodynamics.

Blood pressure alters during the normal menstrual cycle

1986 ◽  
Vol 93 (4) ◽  
pp. 523-526 ◽  
Author(s):  
C. Kelleher ◽  
C. Joyce ◽  
G. Kelly ◽  
J. B. Ferris
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Normal Menstrual Cycle

Blood pressure alters during the normal menstrual cycle

1986 ◽  
Vol 93 (5) ◽  
pp. 523-526 ◽  
Author(s):  
C. Kelleher ◽  
C. Joyce ◽  
G. Kelly ◽  
J. B. Ferris
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Normal Menstrual Cycle

41. Changes in blood pressure during the normal menstrual cycle

1991 ◽  
Vol 9 (6) ◽  
pp. S439
Author(s):  
F. P. Dunne ◽  
D. G. Barry ◽  
J. B. Ferriss ◽  
G. Grealy ◽  
D. Murphy
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Normal Menstrual Cycle

41. Changes in blood pressure during the normal menstrual cycle

1991 ◽  
Vol 9 ◽  
pp. S439
Author(s):  
F. P. Dunne ◽  
D. G. Barry ◽  
J. B. Ferriss ◽  
G. Grealy ◽  
D. Murphy
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Normal Menstrual Cycle

Changes in blood pressure during the normal menstrual cycle

1991 ◽  
Vol 81 (s25) ◽  
pp. 515-518 ◽  
Author(s):  
F. P. Dunne ◽  
D. G. Barry ◽  
J. B. Ferriss ◽  
G. Grealy ◽  
D. Murphy
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Luteal Phase ◽  
Mean Difference ◽  
Menstrual Cycles ◽  
Normal Menstrual Cycle ◽  
At Home

1. Changes in blood pressure during the normal menstrual cycle are not well documented, and previous studies have given conflicting results. 2. Thirty normotensive women and ten mildly hypertensive women measured their blood pressure at home each morning for 6 weeks, under standardized conditions, using a UA-751 semi-automatic sphygmomanometer. All had normal menstrual cycles and subjects entered the study at difference phases of the cycle. 3. Blood pressure was higher at the onset of menstruation than at most other phases of the cycle (systolic blood pressure, P < 0.05; diastolic blood pressure, P < 0.001). Adjusted diastolic blood pressure was higher in the follicular than in the luteal phase (mean difference 1.23 mmHg, P < 0.001). Similarly, blood pressure was lower during days 17–26 than during the remainder of the cycle (adjusted mean difference in systolic blood pressure −0.65 mmHg, P = 0.07; adjusted mean difference in diastolic blood pressure − 1.19 mmHg, P < 0.001). 4. Similar patterns were seen in normotensive and hypertensive subjects, and changes in plasma 17β-oestradiol and progesterone concentrations were also similar in the two groups.

SOME OBSERVATIONS ON PREGNANEDIOL EXCRETION DURING THE NORMAL MENSTRUAL CYCLE

1957 ◽  
Vol 24 (3_Suppl) ◽  
pp. S207
Author(s):  
A. Klopper
Keyword(s):  
Menstrual Cycle ◽  
Corpus Luteum ◽  
New Method ◽  
Menstrual Bleeding ◽  
Normal Menstrual Cycle ◽  
The Relationship ◽  
New View

Abstract The changes in view on the significance and amount of urinary pregnanediol in the menstrual cycle are reviewed; in particular the effects of the discovery that the adrenals in both sexes normally contribute to the urinary pregnanediol. Pregnanediol excretion during the menstrual cycle was studied by means of a new method of assay (Klopper et al., 1955) and the results applied to present day concepts of the growth and duration of the corpus luteum. The relationship between pregnanediol excretion and ovulation or the onset of menstrual bleeding was studied. A new view is put forward on the influence of age and parity on the production of progesterone by the corpus luteum.

Hormone levels in the normal menstrual cycle

Reproduction ◽  
1971 ◽  
Vol 27 (3) ◽  
pp. 481-484 ◽  
Author(s):  
J Newton ◽  
D Joyce ◽  
B Pearce ◽  
C Revell ◽  
J Tyler
Keyword(s):  
Menstrual Cycle ◽  
Hormone Levels ◽  
Normal Menstrual Cycle

Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen

Reproduction ◽  
2000 ◽  
pp. 19-32 ◽  
Author(s):  
ML Martinez ◽  
JD Harris
Keyword(s):  
Menstrual Cycle ◽  
Recombinant Protein ◽  
Antibody Titre ◽  
Zona Pellucida ◽  
Protein A ◽  
Papio Cynocephalus ◽  
Cynomolgus Monkeys ◽  
Menstrual Cycles ◽  
Normal Menstrual Cycle

Immunization of female mammals with native zona pellucida (ZP) proteins is known to cause infertility. Since each human ZP protein is now available as a purified recombinant protein, is it possible to compare the immunocontraceptive potential of each ZP protein. A breeding study was conducted in cynomolgus monkeys (Macaca fasicularis) after immunization with recombinant human ZP (rhZP) proteins (ZPA, ZPB, ZPC) separately and in combinations. This study demonstrated that immunization with recombinant human ZPB (rhZPB) protein caused cynomolgus monkeys to become infertile for 9-35 months. A second study was conducted in baboons (Papio cynocephalus), which yielded a similar result. The baboons immunized with rhZPB became infertile for 9 to > 20 months. During the time of maximum antibody titre, some animals experienced disruption of the menstrual cycle, but eventually all of the animals resumed normal menstrual cycles. Control animals and animals immunized with other rhZP proteins all became pregnant before any of the rhZPB-treated animals. This is the first study in which a recombinant ZP protein has consistently induced infertility in a primate without permanent disruption of the normal menstrual cycle.

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