Analysis of the candidate genes responsible for non-syndromic cleft lip and palate in Japanese people

2000 ◽  
Vol 99 (2) ◽  
pp. 105 ◽  
Author(s):  
Atsuko TANABE ◽  
Shigeru TAKETANI ◽  
Yoko ENDO-ICHIKAWA ◽  
Rikio TOKUNAGA ◽  
Yutaka OGAWA ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Japanese People

scholarly journals 06-P006 Use of stem cells to identify novel signaling pathways and candidate genes associated with Non-Syndromic Cleft Lip and Palate (NSCL/P)

2009 ◽  
Vol 126 ◽  
pp. S121-S122
Author(s):  
Daniela F. Bueno ◽  
Daniele Y. Sunaga ◽  
Gerson S. Kobayashi ◽  
Meire Aguena ◽  
Cassio E.R. Amaral ◽  
...  
Keyword(s):  
Stem Cells ◽  
Signaling Pathways ◽  
Candidate Genes ◽  
Cleft Lip ◽  
Cleft Lip And Palate

scholarly journals Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate

PLoS Genetics ◽  
2005 ◽  
Vol 1 (6) ◽  
pp. e64 ◽  
Author(s):  
Alexandre R Vieira ◽  
Joseph R Avila ◽  
Sandra Daack-Hirsch ◽  
Ecaterina Dragan ◽  
Têmis M Félix ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Cleft Lip ◽  
Cleft Lip And Palate

Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin

2011 ◽  
Vol 119 (6) ◽  
pp. 413-417 ◽  
Author(s):  
Baiba Lace ◽  
Inga Kempa ◽  
Linda Piekuse ◽  
Ieva Grinfelde ◽  
Janis Klovins ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Geographical Origin ◽  
Association Studies

Studies of the Candidate Genes TGFB2, MSX1, TGFA, and TGFB3 in the Etiology of Cleft Lip and Palate in the Philippines

1997 ◽  
Vol 34 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Andrew C. Lidral ◽  
Jeffrey C. Murray ◽  
Kenneth H. Buetow ◽  
Ann M. Basart ◽  
Heidi Schearer ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
The Philippines

scholarly journals Genetic Association Studies of Cleft Lip and/or Palate with Hypodontia outside the Cleft Region

2003 ◽  
Vol 40 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Rebecca L. Slayton ◽  
Laura Williams ◽  
Jeffrey C. Murray ◽  
James J. Wheeler ◽  
Andrew C. Lidral ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Candidate Genes ◽  
Cleft Lip ◽  
Transforming Growth Factor ◽  
Cleft Lip And Palate ◽  
Association Studies ◽  
Polymorphism Analysis ◽  
Missing Teeth ◽  
Orofacial Clefting ◽  
Genotype Information

Objective The purpose of this study was to determine whether the candidate genes previously studied in subjects with cleft lip, cleft palate, or both are associated with hypodontia outside the region of the cleft. Subjects One hundred twenty subjects from the Iowa Craniofacial Anomalies Research Center were selected based on the availability of both dental records and genotype information. Method The type of orofacial clefting and type and location of dental anomalies (missing teeth, supernumerary teeth, or peg laterals) were assessed by dental chart review and radiographic examination. Genotype analysis of candidate genes was performed using polymerase chain reaction/single-strand conformation polymorphism analysis. Results The prevalence of hypodontia in this sample was 47.5%, with 30.0% of subjects having missing teeth outside the cleft. There was a positive association between subjects with cleft lip or cleft lip and palate who had hypodontia outside the cleft region (compared with noncleft controls) and both muscle segment homeo box homolog 1 (MSX1) (p = .029) and transforming growth factor beta 3 (TGFB3) (p = .024). It was not possible in this analysis to determine whether this association was specifically associated with orofacial clefting combined with hypodontia or whether it was due primarily to the clefting phenotype. Conclusions In this sample, there was a significantly greater incidence of hypodontia outside the cleft region in subjects with cleft lip and palate, compared with cleft lip only or cleft palate only. Cleft lip and/or palate with hypodontia outside the cleft region was positively associated with both TGFB3 and MSX1, compared with noncleft controls.

scholarly journals Direct Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate

PLoS Genetics ◽  
2005 ◽  
Vol preprint (2005) ◽  
pp. e64
Author(s):  
Alexandre Rezende Vieira ◽  
Joseph Ross Avila ◽  
Sandra Daack-Hirsch ◽  
Ecaterina Dragan ◽  
Temis M. Felix ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Direct Sequencing
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