Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children

2000 ◽  
Vol 98 (2) ◽  
pp. 137 ◽  
Author(s):  
L.W. DOYLE ◽  
G.W. FORD ◽  
N.M. DAVIS ◽  
C. CALLANAN
Keyword(s):  
Blood Pressure ◽  
Corticosteroid Therapy ◽  
Antenatal Corticosteroid ◽  
Preterm Children

Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children

2000 ◽  
Vol 98 (2) ◽  
pp. 137-142 ◽  
Author(s):  
L. W. DOYLE ◽  
G. W. FORD ◽  
N. M. DAVIS ◽  
C. CALLANAN
Keyword(s):  
Blood Pressure ◽  
Corticosteroid Therapy ◽  
Animal Species ◽  
Antenatal Corticosteroid ◽  
Antenatal Corticosteroids ◽  
Preterm Children ◽  
Clinical Hypertension ◽  
Blood Pressures ◽  
The Relationship ◽  
Mercury Sphygmomanometer

Antenatal corticosteroid therapy substantially improves the survival rate of preterm infants, with few side effects. Higher blood pressure in adulthood has been described in several animal species after exposure to antenatal corticosteroids, but there are no similar reports in humans. The objective of the present study was to determine the relationship between exposure to antenatal corticosteroid therapy and blood pressure at 14 years of age. This was a cohort study of 210 preterm survivors with birthweights of < 1501 g born in the Royal Women's Hospital, Melbourne, between 1 January 1977 and 31 March 1982. Blood pressure was measured in 177 subjects (84.3%) at 14 years of age with a standard mercury sphygmomanometer. Children exposed to antenatal corticosteroids (n = 89) had higher systolic and diastolic blood pressures than those not exposed to corticosteroids (n = 88) [mean difference (95% confidence interval) (mmHg): systolic, 4.1 (0.1–8.0); diastolic, 2.8 (0.05–5.6)]. However, few had blood pressure in the hypertensive range. It is concluded that antenatal corticosteroid therapy is associated with higher systolic and diastolic blood pressures in adolescence, and might lead to clinical hypertension in survivors well beyond birth.

scholarly journals Antenatal Corticosteroid Therapy and Blood Pressure in Adolescence

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 242A-242A
Author(s):  
Lex W Doyle ◽  
Geoffrey W Ford ◽  
Noni M Davis ◽  
Catherine Callanan
Keyword(s):  
Blood Pressure ◽  
Corticosteroid Therapy ◽  
Antenatal Corticosteroid

scholarly journals Antenatal corticosteroid therapy modulates hepatic AMPK phosphorylation and maternal lipid metabolism in early lactating rats

2021 ◽  
Vol 144 ◽  
pp. 112355
Author(s):  
Fernanda Ballerini Hecht ◽  
Caio Jordão Teixeira ◽  
Dailson Nogueira de Souza ◽  
Filiphe de Paula Nunes Mesquita ◽  
Ryana Elyzabeth do Val Roso ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Corticosteroid Therapy ◽  
Antenatal Corticosteroid ◽  
Ampk Phosphorylation
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