Antenatal corticosteroid therapy

2010 ◽  
pp. 104-104
Author(s):  
Leroy C Edozien
Keyword(s):  
Corticosteroid Therapy ◽  
Antenatal Corticosteroid

Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children

2000 ◽  
Vol 98 (2) ◽  
pp. 137-142 ◽  
Author(s):  
L. W. DOYLE ◽  
G. W. FORD ◽  
N. M. DAVIS ◽  
C. CALLANAN
Keyword(s):  
Blood Pressure ◽  
Corticosteroid Therapy ◽  
Animal Species ◽  
Antenatal Corticosteroid ◽  
Antenatal Corticosteroids ◽  
Preterm Children ◽  
Clinical Hypertension ◽  
Blood Pressures ◽  
The Relationship ◽  
Mercury Sphygmomanometer

Antenatal corticosteroid therapy substantially improves the survival rate of preterm infants, with few side effects. Higher blood pressure in adulthood has been described in several animal species after exposure to antenatal corticosteroids, but there are no similar reports in humans. The objective of the present study was to determine the relationship between exposure to antenatal corticosteroid therapy and blood pressure at 14 years of age. This was a cohort study of 210 preterm survivors with birthweights of < 1501 g born in the Royal Women's Hospital, Melbourne, between 1 January 1977 and 31 March 1982. Blood pressure was measured in 177 subjects (84.3%) at 14 years of age with a standard mercury sphygmomanometer. Children exposed to antenatal corticosteroids (n = 89) had higher systolic and diastolic blood pressures than those not exposed to corticosteroids (n = 88) [mean difference (95% confidence interval) (mmHg): systolic, 4.1 (0.1–8.0); diastolic, 2.8 (0.05–5.6)]. However, few had blood pressure in the hypertensive range. It is concluded that antenatal corticosteroid therapy is associated with higher systolic and diastolic blood pressures in adolescence, and might lead to clinical hypertension in survivors well beyond birth.

scholarly journals Antenatal corticosteroid therapy modulates hepatic AMPK phosphorylation and maternal lipid metabolism in early lactating rats

2021 ◽  
Vol 144 ◽  
pp. 112355
Author(s):  
Fernanda Ballerini Hecht ◽  
Caio Jordão Teixeira ◽  
Dailson Nogueira de Souza ◽  
Filiphe de Paula Nunes Mesquita ◽  
Ryana Elyzabeth do Val Roso ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Corticosteroid Therapy ◽  
Antenatal Corticosteroid ◽  
Ampk Phosphorylation

scholarly journals Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation

2018 ◽  
Vol 61 (1) ◽  
pp. R61-R73 ◽  
Author(s):  
Emma J Agnew ◽  
Jessica R Ivy ◽  
Sarah J Stock ◽  
Karen E Chapman
Keyword(s):  
Corticosteroid Therapy ◽  
Fetal Heart ◽  
Antenatal Corticosteroid ◽  
Lung Maturation ◽  
Glucocorticoid Treatment ◽  
Life Saving ◽  
Preterm Babies ◽  
Fetal Organs ◽  
Synthetic Glucocorticoids ◽  
Glucocorticoid Action

Glucocorticoids are essential in mammals to mature fetal organs and tissues in order to survive after birth. Hence, antenatal glucocorticoid treatment (termed antenatal corticosteroid therapy) can be life-saving in preterm babies and is commonly used in women at risk of preterm birth. While the effects of glucocorticoids on lung maturation have been well described, the effects on the fetal heart remain less clear. Experiments in mice have shown that endogenous glucocorticoid action is required to mature the fetal heart. However, whether the potent synthetic glucocorticoids used in antenatal corticosteroid therapy have similar maturational effects on the fetal heart is less clear. Moreover, antenatal corticosteroid therapy may increase the risk of cardiovascular disease in adulthood. Here, we present a narrative review of the evidence relating to the effects of antenatal glucocorticoid action on the fetal heart and discuss the implications for antenatal corticosteroid therapy.

scholarly journals Cost-effectiveness of Antenatal Corticosteroid Therapy vs No Therapy in Women at Risk of Late Preterm Delivery

2019 ◽  
Vol 173 (5) ◽  
pp. 462 ◽  
Author(s):  
Cynthia Gyamfi-Bannerman ◽  
John A. F. Zupancic ◽  
Grecio Sandoval ◽  
William A. Grobman ◽  
Sean C. Blackwell ◽  
...  
Keyword(s):  
At Risk ◽  
Cost Effectiveness ◽  
Preterm Delivery ◽  
Corticosteroid Therapy ◽  
Late Preterm ◽  
Antenatal Corticosteroid
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