Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease

1999 ◽  
Vol 96 (6) ◽  
pp. 543 ◽  
Author(s):  
Muneo YOSHIBAYASHI ◽  
Tetsuro KAMIYA ◽  
Toshio NISHIKIMI ◽  
Yoshihiko SAITO ◽  
Hisayuki MATSUO ◽  
...  
Keyword(s):  
Heart Disease ◽  
Plasma Levels ◽  
Cyanotic Heart Disease ◽  
Elevated Plasma ◽  
Congenital Cyanotic Heart Disease

Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease

1999 ◽  
Vol 96 (6) ◽  
pp. 543-547 ◽  
Author(s):  
Muneo YOSHIBAYASHI ◽  
Tetsuro KAMIYA ◽  
Toshio NISHIKIMI ◽  
Yoshihiko SAITO ◽  
Hisayuki MATSUO ◽  
...  
Keyword(s):  
Heart Disease ◽  
Pulmonary Circulation ◽  
Venous Blood ◽  
Compensatory Mechanism ◽  
Cyanotic Heart Disease ◽  
Elevated Plasma ◽  
Arterial Blood ◽  
Pulmonary Uptake ◽  
Pulmonary Arterial ◽  
Congenital Cyanotic Heart Disease

Adrenomedullin is a novel hypotensive peptide originally isolated from human pheochromocytoma. Accumulating evidence suggests the possible involvement of adrenomedullin in the physiology of the pulmonary circulation and the pathophysiology of hypoxaemia. The aim of the present study was to investigate the pathophysiological significance of adrenomedullin in hypoxaemia caused by congenital cyanotic heart disease. Subjects were 16 patients with congenital cyanotic heart disease aged 0.8–10 years (Group C) and 12 age-matched control subjects (patients with coronary artery dilatation after Kawasaki disease; Group N). Plasma adrenomedullin concentrations were measured, using radioimmunoassay, in femoral venous, pulmonary arterial and pulmonary venous blood obtained during cardiac catheterization. Plasma adrenomedullin concentrations in Group C were significantly (3-fold) higher than those in Group N at all sampling sites. In Group C, plasma adrenomedullin concentrations in pulmonary venous blood were significantly lower than those in pulmonary arterial blood. Pulmonary uptake of adrenomedullin in Group C was significantly greater than that in Group N. Patients with congenital cyanotic heart disease showed elevated plasma adrenomedullin concentrations and an increased uptake of adrenomedullin in the pulmonary circulation, which may act to dilate pulmonary vessels and increase pulmonary blood flow to alleviate hypoxaemia. Intrinsically increased adrenomedullin levels may function as a compensatory mechanism for hypoxaemia in congenital cyanotic heart disease.

Cyanosis and Clipping: Noninfectious Aneurysm in a Patient with 22q11.2 Deletion Syndrome

2021 ◽  
pp. 1-5
Author(s):  
Bhanu Jayanand Sudhir ◽  
Sanjay Honavalli Murali ◽  
Jaypalsinh Gohil ◽  
Rajalakshmi Poyuran ◽  
Manikantan Sethuraman ◽  
...  
Keyword(s):  
Heart Disease ◽  
Cerebral Aneurysms ◽  
Artery Aneurysm ◽  
22Q11.2 Deletion Syndrome ◽  
Neurological Deficits ◽  
Deletion Syndrome ◽  
Anterior Communicating Artery ◽  
Cyanotic Heart Disease ◽  
22Q11.2 Deletion ◽  
Congenital Cyanotic Heart Disease

Noninfectious cerebral aneurysms are rare in patients with congenital cyanotic heart disease. We present a patient with DiGeorge/velocardiofacial syndrome with a complex congenital cyanotic heart disease with a ruptured anterior communicating artery aneurysm. The 10-year-old child was managed by surgical clipping of the aneurysm. Surgical challenges included prominent veins in the Sylvian fissure, difficulty in differentiating arterial and venous bleed, and anesthetic risks. The patient recovered without any neurological deficits. This is the first report of a patient with 22q11.2 deletion syndrome, with a noninfectious cerebral aneurysm.

Selective coronary angiography via antegrade venous route in congenital cyanotic heart disease

1993 ◽  
Vol 28 (2) ◽  
pp. 179-182 ◽  
Author(s):  
Yunus S. Loya ◽  
Robin J. Pinto ◽  
Dhruman M. Desai ◽  
Usha Sundaram ◽  
Ajit R. Bhagwat ◽  
...  
Keyword(s):  
Heart Disease ◽  
Coronary Angiography ◽  
Cyanotic Heart Disease ◽  
Selective Coronary Angiography ◽  
Congenital Cyanotic Heart Disease

Determinants of platelet count in pediatric patients with congenital cyanotic heart disease: Role of immature platelet fraction

2017 ◽  
Vol 13 (1) ◽  
pp. 118-123 ◽  
Author(s):  
Randa M. Matter ◽  
Iman A. Ragab ◽  
Alaa M. Roushdy ◽  
Ahmed G. Ahmed ◽  
Hanan H. Aly ◽  
...  
Keyword(s):  
Platelet Count ◽  
Heart Disease ◽  
Pediatric Patients ◽  
Cyanotic Heart Disease ◽  
Immature Platelet Fraction ◽  
Congenital Cyanotic Heart Disease

ONE OF THE EARLIEST CLINICAL AND POSTMORTEM DESCRIPTIONS OF CYANOTIC CONGENITAL HEART DISEASE REPORTED IN THE UNITED STATES

PEDIATRICS ◽  
1969 ◽  
Vol 43 (4) ◽  
pp. 577-577
Author(s):  
T. E. C.
Keyword(s):  
Heart Disease ◽  
New England ◽  
Maternal Care ◽  
Congenital Heart ◽  
The United States ◽  
Cyanotic Congenital Heart Disease ◽  
Cyanotic Heart Disease ◽  
Considerable Time ◽  
Congenital Cyanotic Heart Disease ◽  
Unusual Shape

The first volume of the New England Journal of Medicine and Surgery, which appeared in 1812, contained this succinct description of congenital cyanotic heart disease in a young girl: S.R. when born was for a considerable time supposed to be dead-did not cry, or evince any living actions. The lungs were artificially inflated for several minutes and life at length appeared, but very feebly.-A livid countenance, with frequent syncope took place.-With great maternal care the infant was kept alive, and as she grew became remarkably sprightly and active. When two years old (she) was unusually intelligent and fond of exercise.-As she advanced in age her fondness for violent exercise in playing often exposed her danger, as these efforts never failed to produce syncope and a kind of convulsion, laughing, crying, any emotion of mind, also brought on the syncope, from which after falling into a horizontal position, she generally soon recovered.-Her countenance, all times blueish and livid, was in these fits extremely extremely so. Her nails were always of the colour of litmus, or perhaps a little nearer to violet. After death the thorax was examined-it was of an unusual shape, being more cylindrical than common, and the lungs having less the form of a cloven hoof, when inflated, than they usually assume.-The heart was very small. In place of a right auricle was observed a small appendage like the edge of that portion of the heart, not capable of containing more than one fourth its usual contents.

Tuberculosis and congenital cyanotic heart disease

1954 ◽  
Vol 16 (4) ◽  
pp. 528-534 ◽  
Author(s):  
Robert D. Sloan ◽  
C.Rollins Hanlon ◽  
H.William Scott
Keyword(s):  
Heart Disease ◽  
Cyanotic Heart Disease ◽  
Congenital Cyanotic Heart Disease

Accuracy of pulse oximeters at low oxygen saturations in children with congenital cyanotic heart disease: An observational study

2019 ◽  
Vol 29 (6) ◽  
pp. 597-603 ◽  
Author(s):  
Eun‐Hee Kim ◽  
Ji‐Hyun Lee ◽  
In‐Kyung Song ◽  
Hee‐Soo Kim ◽  
Young‐Eun Jang ◽  
...  
Keyword(s):  
Heart Disease ◽  
Observational Study ◽  
Cyanotic Heart Disease ◽  
Low Oxygen ◽  
Congenital Cyanotic Heart Disease ◽  
Pulse Oximeters
Sign in / Sign up

Export Citation Format

Share Document