The Effect of Vitamin E and Ubiquinone-10 Supplementation on Physical Performance and Muscle Metabolism

1994 ◽  
Vol 87 (s1) ◽  
pp. 80-81
Author(s):  
B Ostman ◽  
P Foxdal ◽  
A Sjodin ◽  
S Branth ◽  
B Sjodin
2021 ◽  
Vol 4 (11(75)) ◽  
pp. 11-16
Author(s):  
А. Kurylenko ◽  
O. Kurylenko ◽  
О. Kuchmenko ◽  
V. Havii

Purpose. The aim of the study is to investigate the effect of pre-sowing treatment of winter rye seeds of Synthetic 38 and Zabava with compositions of metabolically active substances on the content of photosynthetic pigments in plant leaves at different phases of ontogenesis. Materials and methods. The research materials were winter rye varieties Synthetic 38 and Zabava, and combinations of metabolically active substances: vitamin E (10-8M), paraoxybenzoic acid (0,001%), methionine (0,001%), ubiquinone-10 (10-8M) and MgSO4 (0,001%). The research scheme provided 4 options: 1) control (untreated seeds); 2) seeds, treated with a composition of substances: vitamin E + paraoxybenzoic acid + methionine + MgSO4; 3) seeds treated with a composition of substances: vitamin E + paraoxybenzoic acid + methionine; 4) seeds, processing by composition of substances: vitamin E + ubiquinone-10. Studies were conducted in the following phases of rye development: tillering, tubing, earing, flowering. The content of pigments - chlorophyll a, b and the total content of chlorophyll in the leaves of rye plants was determined by spectrophotometric method. Results and conclusions. It was demonstrated for the first time that the use of compositions of metabolically active compounds for pre-sowing treatment of winter rye varieties Synthetic 38 and Zabava leads to an increase of main chlorophyll, chlorophyll a and b in plant leaves in the dynamics from tillering to flowering. The composition consisting of vitamin E, para-oxybenzoic acid, methionine and MgSO4 showed the greatest efficiency. The effectiveness of this composition may be due to the complex action of all metabolically active compounds that are part of it. The obtained results may indicate a potentially more efficient absorption and conversion of energy by plants and the positive effect of these compositions on the photosynthesis of winter rye plants. Substances that have shown their effectiveness can be used as components of stimulants.


1971 ◽  
Vol 49 (11) ◽  
pp. 1202-1208 ◽  
Author(s):  
Naranjan S. Dhalla ◽  
Margaret Fedelesova ◽  
Ivan Toffler

Rats were fed a vitamin E deficient diet for 5–10 weeks and the energy state of the hind leg muscle was examined. Both creatine phosphate and ATP were decreased by 64 and 22% of the control values, respectively, in the skeletal muscles of rats on the vitamin E deficient diet for 10 weeks, whereas ADP was increased by more than 100% without any significant changes in the level of AMP. The ratios ATP/ADP and ATP/AMP also declined markedly in the hind leg muscles of the rats on the vitamin E deficient diet for 10 weeks. The concentrations of NAD+ and NADPH decreased, whereas no significant changes in the levels of NADH and NADP+ were observed in the muscles of vitamin E deficient animals. Feeding a normal diet for 4 weeks to rats previously on the vitamin E deficient diet was found to restore the energy state of the muscle towards normal. Although no changes in the ultrastructure of the skeletal muscle were apparent, the levels of lactate and pyruvate as well as the lactate/pyruvate ratio were increased in vitamin E deficiency. The activities of lactate dehydrogenase and malate dehydrogenase were decreased whereas α-glycerophosphate dehydrogenase activity did not change significantly. These results indicate a dramatic alteration in skeletal muscle metabolism of vitamin E deficient rats. It is suggested that such a change may partly be due to a defect in the process of energy production.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A234-A235
Author(s):  
So Jeong Park ◽  
Da Ae Kim ◽  
Jin Young Lee ◽  
Beom-Jun Kim

Abstract Background: The C-C motif chemokine ligand 11 (CCL11) has been receiving attention as a potential pro-aging factor and thus may be also involved in muscle metabolism and sarcopenia, a key component of aging phenotypes. To clarify this possibility, we investigated the effects of CCL11 on in vitro muscle biology and clinical relevance with sarcopenia parameters in older adults. Methods: Primary mouse myoblasts and C2C12 cells were used for experimental research. Blood samples were collected from 79 participants who underwent a functional assessment, and CCL11 level was measured using a quantikine ELISA kit. Sarcopenia was diagnosed using the Asian-specific cut-off points. Results: CCL11 treatment stimulated the differentiation of both primary myoblasts and C2C12 cells into mature myotubes, and consistently increased the expression of myogenic differentiation markers, such as myosin heavy chain and myogenin. Among C-C chemokine receptors (CCRs), CCR5, not CCR2 and CCR3, was predominantly expressed in muscle cells, and CCR5 inhibitor blocked CCL11-stimulated myogenesis. In a clinical study, after adjustment for sex, age, and body mass index, serum CCL11 level was not significantly different according to the status of sarcopenia, low muscle mass, low muscle strength, and low physical performance, and was not associated with any of skeletal muscle index, grip strength, gait speed, time to complete 5 chair stands, and short physical performance battery score. Conclusions: Contrary to expectations, CCL11 showed the beneficial effects on muscle metabolism at least in vitro system. However, the role of CCL11 on muscle health in humans was not evident, suggesting that circulating CCL11 level may not be a useful biomarker for sarcopenia risk assessment in older adults.


2016 ◽  
Vol 7 (12) ◽  
pp. 4920-4934 ◽  
Author(s):  
X. Capó ◽  
M. Martorell ◽  
C. Busquets-Cortés ◽  
A. Sureda ◽  
J. Riera ◽  
...  

Functional beverages based on almonds and olive oil and enriched with α-tocopherol and docosahexaenoic acid (DHA) could be useful in modulating oxidative stress and enhancing physical performance in sportsmen.


Author(s):  
A. G. Koziuchko ◽  
V. M. Havii ◽  
O. B. Kuchmenko

Soy is an important food, feed and technical crop of agriculture in many countries across the world. It differs from other agricultural crops by its unique combination of protein and oil with valuable vitamins and elements. Without the use of fertilizers, it is impossible to get a large soybean crop. Among the main factors that influence the yield of this crop, fertilizers account for 30%, varieties -20%, weather conditions and plant protection - 15%, effective fertility and soil treatment - 10%. Therefore, the study of the effect of a combination of metabolically active substances (complexes of vitamin E and ubiquinone-10; vitamin E, 4-hydroxibenzoic acid (PHBE) and methionine; vitamin E, 4-hydroxibenzoic acid (PHBE), methionine and magnesium sulfate on individual physiological parameters of soy in the main phases of ontogenesis and its performance is worthy of scientific attention. The research demonstrated that in the phase of formation of the triple leaf, the studied substances effectively stimulated the length of the main stem, the number of leaves and the area of the leaf surface. In the flowering phase, complexes of vitamin E and ubiquinone-10, and vitamin E, PHBE, methionine and magnesium sulfate increased the number of lateral roots by 132.2% and 114.3%, respectively. In addition, the studied metabolically active substances positively affected the length of the stem, number of leaves, leaf area and length of lateral roots. In the maturation phase, the complex of vitamin E and ubiquinone-10 effectively stimulated the height of plants, the number of beans per plant, exceeding the control parameters by 15.5%, 14.2%, respectively. In addition, the studied substances affected the number of seeds per soybean plant. So, in the control group, the number of seeds from one plant averaged 140.7 units. The best results were obtained using the combination of vitamin E, PHBE, methionine and magnesium sulfate and amounted to 154.4 units, which exceeded the control indices by 9.7%. While the number of seeds from one plant after treatment with a combination of vitamin E and ubiquinone-10 amounted to 148.3 units, which exceeded the control indicators by 5.4%. The highest soybean yield was observed during seed treatment with a combination of vitamin E and ubiquinone-10, and amounted to 2.37 t / ha, exceeding the control indicators by 26.3%. Seed treatment with complex of vitamin E, PHBE, methionine and magnesium sulfate also showed a good result, exceeding the control indicators by 10.2%. Thus, the complexes of vitamin E and ubiquinone-10, and vitamin E, PHBE, methionine and magnesium sulfate showed better results, so further study of the effect of these substances on legumes is promising.


Gerontology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Ha Thi Nga ◽  
Il-Young Jang ◽  
Da Ae Kim ◽  
So Jeong Park ◽  
Jin Young Lee ◽  
...  

Background: Growth differentiation factor 15 (GDF15), induced by tissue inflammation and mitochondrial stress, has received significant attention as a biomarker of mitochondrial dysfunction and has been implicated in various age-related diseases. However, the association between circulating GDF15 and sarcopenia-associated outcomes in older adults remains to be established. Aim: To validate previous experimental data and to investigate the possible role of GDF15 in aging and muscle physiology in humans, this study examined serum GDF15 levels in relation to sarcopenia-related parameters in a cohort of older Asian adults. Methods: Muscle mass and muscle function-related parameters, such as grip strength, gait speed, chair stands, and short physical performance battery score were evaluated by experienced nurses in 125 geriatric participants with or without sarcopenia. Sarcopenia was diagnosed using the Asian-specific cutoff points. Serum GDF15 levels were measured using an enzyme immunoassay kit. Results: Serum GDF15 levels were not significantly different according to sarcopenia status, muscle mass, muscle strength, and physical performance and were not associated with the skeletal muscle index, grip strength, gait speed, time to complete 5 chair stands, and short physical performance battery score, regardless of adjustments for sex, age, and BMI. Conclusions: These findings indicate that the definite role of GDF15 on muscle metabolism observed in animal models might not be evident in humans and that elevated GDF15 levels might not predict the risk for sarcopenia, at least in older Asian adults.


2009 ◽  
Vol 21 (2) ◽  
pp. 111-121 ◽  
Author(s):  
Özgür Nalbant ◽  
Ne§e Tokta§ ◽  
N. Füsun Toraman ◽  
Candan Öğü§ ◽  
Hülya Aydın ◽  
...  

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