Sodium-lithium countertransport and platelet cytosolic free calcium concentration in relation to peripheral insulin sensitivity in postmenopausal women

1992 ◽  
Vol 83 (3) ◽  
pp. 319-324 ◽  
Author(s):  
Ingrid Mattiasson ◽  
Kerstin Berntorp ◽  
Folke Lindgärde
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Normal Glucose Tolerance ◽  
Insulin Concentration ◽  
Glucose Disposal ◽  
Plasma Insulin Concentration ◽  
Normal Glucose ◽  
Basal Plasma

1. Peripheral glucose disposal (assessed by the euglycaemic-hyperinsulinaemic clamp technique), Na+-Li+ countertransport in erythrocytes and the cytosolic free Ca2+ concentration in platelets were determined in 41 women with impaired glucose tolerance and in 38 women with normal glucose tolerance. The groups were matched for body mass index (range 18–44 kg/m2) and diastolic blood pressure (range 58–109 mmHg). 2. Na+-Li+ countertransport was correlated significantly with body mass index, basal plasma insulin concentration and basal plasma glucose concentration, and was inversely correlated with peripheral glucose disposal rate. Stepwise regression analysis showed that Na+-Li+ countertransport was positively correlated with basal plasma insulin concentration (r2 = 8.7%). 3. Systolic blood pressure was correlated with fasting plasma insulin concentration (model r2 = 25%) and with Na+-Li+ countertransport (model r2 = 34%) in the group with impaired glucose tolerance. In the group with normal glucose tolerance there were no correlations between blood pressure and Na+-Li+ countertransport. 4. No correlation was found between platelet cytosolic free Ca2+ concentration and any of the variables measured. 5. It is concluded that Na+-Li+ countertransport is correlated with the degree of peripheral insulin sensitivity and with the plasma insulin concentration. Platelet cytosolic free Ca2+ concentration was not correlated with any of these variables, and there was no relationship between Na+-Li+ countertransport and the platelet cytosolic free Ca2+ concentration.

Plasma insulin and blood pressure in normotensive Japanese men with normal glucose tolerance

1995 ◽  
Vol 13 (4) ◽  
pp. 427???432 ◽  
Author(s):  
Katsuyuki Miura ◽  
Hideaki Nakagawa ◽  
Muneko Nishijo ◽  
Masaji Tabata ◽  
Yuko Morikawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Normal Glucose Tolerance ◽  
Japanese Men ◽  
Normal Glucose

Oscillations enhance the efficiency and stability of glucose disposal

1986 ◽  
Vol 250 (5) ◽  
pp. E576-E582 ◽  
Author(s):  
B. D. Marsh ◽  
D. J. Marsh ◽  
R. N. Bergman
Keyword(s):  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Normal Glucose Tolerance ◽  
Glucose Infusion ◽  
Glucose Disposal ◽  
Glucose Levels ◽  
Normal Glucose ◽  
Total Glucose ◽  
Mean Glucose

Oscillations in plasma concentrations of glucose and insulin as well as the rates of glucose disposal by liver and periphery have been observed in dogs during states of net glucose anabolism. To examine whether the existence of oscillations is important for efficient disposal of nutrients, we compared constant glucose infusion (with plasma glucose and insulin oscillations) to experiments in which glucose oscillations were suppressed using the glucose clamp. Mean glucose levels attained were the same for the two protocols (142 +/- 2 for constant glucose infusion at 10.8 +/- 0.4 mg X kg-1 X min-1, 144 +/- 1 mg/dl for clamps, P = 0.35). Despite matched mean glucose, integrated plasma insulin was 36.3 +/- 3.2 mU X ml-1 X 600 min in controls but higher in clamps (53.8 +/- 9.1 mU X ml-1 X 600 min, P = 0.017). Despite 48% higher insulin, total glucose disposed during the 10-h clamps was not greater than during constant glucose infusion (clamps, 162.1 +/- 10.7 g/600 min; infusions, 154.4 +/- 7.5 g/600 min; P = 0.19). These studies demonstrate that the presence of coordinated oscillations in glucose and insulin, during glucose infusion, are associated with more efficient disposal of glucose than when oscillations are suppressed. The results suggest that oscillations may play an important role in the efficient disposal of administered nutrient and may be an important component of normal glucose tolerance.

Insulin resistance and Na+/K+-ATPase in hypertensive women: a difference in mechanism depending on the level of glucose tolerance

1992 ◽  
Vol 82 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Ingrid Mattiasson ◽  
Kerstin Berntorp ◽  
Folke Lindgärde
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Sex Hormone Binding Globulin ◽  
Glucose Disposal ◽  
Hormone Binding ◽  
Efflux Rate ◽  
Normal Glucose ◽  
Glucose Disposal Rate

1. The peripheral glucose disposal rate (assessed with the euglycaemic-hyperinsulinaemic clamp technique), the serum sex hormone-binding globulin concentration and total and ouabain-sensitive 22Na-efflux rate constants in leucocytes were determined in 41 women with impaired glucose tolerance and in 40 women with normal glucose tolerance. The groups were matched for body mass index and diastolic blood pressure (range 55-112 mmHg). 2. Stepwise regression analysis showed that diastolic blood pressure in the group with impaired glucose tolerance was inversely correlated with the glucose disposal rate (model r2 = 21%) and was correlated with the plasma glucose concentration at 120 min after an oral glucose load (model r2 = 31%). In the group with normal glucose tolerance, however, neither of these two variables was correlated with blood pressure, although the ouabain-sensitive 22Na efflux rate constant was (model r2=11%). 3. Among insulin-resistant subjects, those with hypertension had significantly lower serum sex hormone-binding globulin concentrations than the normotensive subjects. 4. We conclude that insulin resistance is correlated with high blood pressure in women with glucose intolerance and increased androgenic activity. In women with normal insulin sensitivity, a low level of the Na+/K+-ATPase-mediated sodium efflux is associated with high blood pressure.

Effects of exenatide and liraglutide on postchallenge glucose disposal in individuals with normal glucose tolerance

Endocrine ◽  
2018 ◽  
Vol 64 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Yushi Hirota ◽  
Tomokazu Matsuda ◽  
Shinsuke Nakajima ◽  
Michinori Takabe ◽  
Naoko Hashimoto ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Glucose Disposal ◽  
Normal Glucose

scholarly journals Glucose–insulin relationships and thyroid status of cockerels selected for high or low residual food consumption

2000 ◽  
Vol 83 (6) ◽  
pp. 645-651 ◽  
Author(s):  
Jean-François Gabarrou ◽  
Pierre Andre Geraert ◽  
John Williams ◽  
Laurent Ruffier ◽  
Nicole Rideau
Keyword(s):  
Food Consumption ◽  
Plasma Glucose ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Insulin Concentration ◽  
Glucose Disposal ◽  
Oral Glucose ◽  
Thyroid Status ◽  
Plasma Insulin Concentration ◽  
Diet Induced Thermogenesis

The plasma glucose–insulin relationships and thyroid status were investigated in two lines of adult cockerels divergently selected for high (R+) or low (R-) residual food consumption (RFC). For a given body weight, R+ birds had a 74 % higher food intake than R- birds. Plasma glucose concentrations were significantly lower in the R+ line compared with the R- when fasted, whereas R+ birds exhibited a significantly lower plasma insulin concentration than R- birds either in fed or fasted state. After an overnight fast, R+ birds also exhibited a higher sensitivity to exogenous insulin in view of its more pronounced hypoglycaemic effect. After an oral glucose load, the glucose disposal of R+ cockerels was faster despite lower glucose-induced plasma insulin concentration. Whilst plasma triacylglycerol concentrations were lower in the R+ line when fed, plasma non-esterified fatty acid concentrations were higher in fasted R+ than R- cockerels (684v.522 μmol/l). Higher plasma triiodothyronine concentrations were observed in fed R+ compared with R- birds (3·0v.2·1 nmol/l respectively). The higher plasma concentrations of triiodothyronine associated with lower concentrations of insulin could account for the leanness and the elevated diet-induced thermogenesis previously observed in the R+ line.

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