Arachidonic Acid Status in Peripheral Blood in Sarcoidosis

1986 ◽  
Vol 71 (s15) ◽  
pp. 65P-66P
Author(s):  
J.T. Power ◽  
F. Hogan ◽  
W. Maxwell ◽  
J. Walsh ◽  
L. Clancy ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Peripheral Blood ◽  
Acid Status

Arachidonic acid and LTB4 enhance aggregation of psoriatic peripheral blood mononuclear leukocytes in vitro

1987 ◽  
Vol 279 (5) ◽  
pp. 347-350 ◽  
Author(s):  
P. D. Pigatto ◽  
M. M. Polengni ◽  
G. F. Altomare ◽  
G. L. Tadini ◽  
S. Villa
Keyword(s):  
Arachidonic Acid ◽  
Peripheral Blood ◽  
Mononuclear Leukocytes ◽  
Peripheral Blood Mononuclear

scholarly journals A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans

2019 ◽  
Vol 121 (11) ◽  
pp. 1201-1214 ◽  
Author(s):  
Philip C. Calder ◽  
Cristina Campoy ◽  
Ans Eilander ◽  
Mathilde Fleith ◽  
Stewart Forsyth ◽  
...  
Keyword(s):  
Systematic Review ◽  
Arachidonic Acid ◽  
Blood Clotting ◽  
Blood Lipids ◽  
Ageing Population ◽  
Health Related ◽  
Acid Status ◽  
Randomised Controlled ◽  
Higher Doses ◽  
Specific Health

AbstractWe conducted a systematic review of randomised controlled trials (RCT) of increased intake of arachidonic acid (ARA) on fatty acid status and health outcomes in humans. We identified twenty-two articles from fourteen RCT. Most studies were conducted in adults. These used between 80 and 2000 mg ARA per d and were of 1–12 weeks duration. Supplementation with ARA doses as low as 80 mg/d increased the content of ARA in different blood fractions. Overall there seem to be few marked benefits for adults of increasing ARA intake from the typical usual intake of 100–200 mg/d to as much as 1000 mg/d; the few studies using higher doses (1500 or 2000 mg/d) also report little benefit. However, there may be an impact of ARA on cognitive and muscle function which could be particularly relevant in the ageing population. The studies reviewed here suggest no adverse effects in adults of increased ARA intake up to at least 1000–1500 mg/d on blood lipids, platelet aggregation and blood clotting, immune function, inflammation or urinary excretion of ARA metabolites. However, in many areas there are insufficient studies to make firm conclusions, and higher intakes of ARA are deserving of further study. Based on the RCT reviewed, there are not enough data to make any recommendations for specific health effects of ARA intake.

Telomere Length in Healthy Adults Is Positively Associated With Polyunsaturated Fatty Acids, Including Arachidonic Acid, and Negatively With Saturated Fatty Acids

2020 ◽  
Vol 76 (1) ◽  
pp. 3-6
Author(s):  
Varinderpal S Dhillon ◽  
Permal Deo ◽  
Ann Chua ◽  
Phil Thomas ◽  
Michael Fenech
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid ◽  
Blood Cell ◽  
Telomere Length ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Saturated Fatty Acids ◽  
Fatty Acid Status ◽  
Acid Status

Abstract Lymphocyte telomere length (LTL) is a biomarker of aging that may be modified by dietary factors including fat. Red blood cell fatty acid status is a well-validated indicator of long-term dietary intake of fat from various sources. Recent findings from epidemiological studies of LTL in relation to fatty acids in red blood cells are not conclusive. The present study was carried out to investigate if red blood cell fatty acid status in 174 healthy older South Australians is associated with LTL. Lymphocyte telomere length was measured by real-time qPCR and fatty acid content in red blood cells was measured by gas chromatography. Our results indicate that the majority of saturated fatty acids and monounsaturated fatty acids are negatively associated with LTL, whereas polyunsaturated fatty acids are positively associated with LTL. Multiple regression analysis revealed that arachidonic acid (C20:4n-6) is significantly, independently, positively correlated with LTL (β = 0.262; p = .000). The significant association of fatty acids, particularly C20:4n-6, with telomere length warrants further research.

scholarly journals Essential Fatty Acids in the Fetal and Newborn Lamb

1985 ◽  
Vol 38 (1) ◽  
pp. 33 ◽  
Author(s):  
MA Rajion ◽  
JG McLean ◽  
R NP Cahill
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Essential Fatty Acids ◽  
Fatty Acid Status ◽  
Newborn Lamb ◽  
Acid Ratio ◽  
Fetal Lamb ◽  
Acid Status ◽  
Low Levels ◽  
Long Chain

The concentrations of linoleic and linolenic acids and their metabolites in the liver, kidney, brain, erythrocytes and plasma of fetal lambs at various stages of gestation, and of newborn and 2-week-01d suckled lambs was determined. Throughout gestation the fetal tissues, erythrocytes and plasma all contained low levels of linoleic and linolenic acids together with consistently high levels of their long-chain polyunsaturated metabolites. The triene : tetraene (eicosa-5,8, 11-trienoic acid/arachidonic acid) ratio was always 0 . 4 or less except at birth when it reached 0 . 6 in liver and 0 . 9 in plasma. Milk intake significantly increased the linoleic and linolenic acid levels in the lamb by 2 weeks after birth. These results show that the developing fetal lamb should not be regarded as being deficient in essential fatty acids, as suggested by previous investigators. It is proposed that the total metabolites of linoleic and linolenic acids are the most appropriate measure of the essential fatty acid status of the fetal lamb.

scholarly journals Thromboxane generation by human peripheral blood polymorphonuclear leukocytes.

1978 ◽  
Vol 148 (3) ◽  
pp. 787-792 ◽  
Author(s):  
I M Goldstein ◽  
C L Malmsten ◽  
H Kindahl ◽  
H B Kaplan ◽  
O Rådmark ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Arachidonic Acid ◽  
Thin Layer ◽  
Peripheral Blood ◽  
Polymorphonuclear Leukocytes ◽  
Cytochalasin B ◽  
Human Peripheral Blood ◽  
Thromboxane B2 ◽  
Cyclooxygenase Inhibitor

Human peripheral blood polymorphonuclear leukocytes were stimulated to generate thromboxane B2 in a time- and concentration-dependent fashion upon exposure to serum-treated zymosan particles. Conversion by stimulated PMN of [14C] arachidonic acid to [14C]thromboxane B2 was confirmed by thin-layer radiochromatography, radio-gas chromatography, and mass spectrometry. Generation of thromboxane B2 was independent of platelet contamination and could be inhibited by the cyclooxygenase inhibitor, indomethacin. Cells rendered incapable of ingesting particles by treatment with cytochalasin B generated comparable amounts of thromboxane B2. These results suggest that human peripheral blood polymorphonuclear leukocytes synthesize thromboxanes in response to surface stimulation independently of phagocytosis.

Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants

Lipids ◽  
2001 ◽  
Vol 36 (6) ◽  
pp. 555-566 ◽  
Author(s):  
Hans Demmelmair ◽  
Franziska Feldl ◽  
Imre Horváth ◽  
Tamás Niederland ◽  
Viktória Ruszinkó ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Fish Oil ◽  
Premature Infants ◽  
Borage Oil ◽  
Acid Status
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