The Effect of Prednisolone on Arterial Oxygen Saturation during Exercise in Patients with Chronic Obstructive Airways Disease

1986 ◽  
Vol 70 (s13) ◽  
pp. 60P-60P
Author(s):  
CR Swinburn ◽  
JM Wakefield ◽  
PW Jones
Keyword(s):  
Oxygen Saturation ◽  
Arterial Oxygen Saturation ◽  
Arterial Oxygen ◽  
Chronic Obstructive ◽  
Obstructive Airways Disease ◽  
Chronic Obstructive Airways Disease

Arterial oxygen saturation and breathlessness in patients with chronic obstructive airways disease

1987 ◽  
Vol 72 (6) ◽  
pp. 693-698 ◽  
Author(s):  
R. Lane ◽  
A. Cockcroft ◽  
L. Adams ◽  
A. Guz
Keyword(s):  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Arterial Oxygen Saturation ◽  
Supplemental Oxygen ◽  
Arterial Oxygen ◽  
Chronic Obstructive ◽  
Exercise Ventilation ◽  
Vas Scores ◽  
Obstructive Airways Disease ◽  
Chronic Obstructive Airways Disease

1. Nine patients with chronic obstructive airways disease performed a 6 min self-paced walk (breathing air) on a treadmill and then identical (but operator-controlled) treadmill walks breathing either air or supplemental oxygen sufficient to just prevent arterial oxygen desaturation during the exercise. 2. During the exercises, ventilation was recorded and patients recorded their sensation of breathlessness on a visual analogue scale (VAS) every 30 s. 3. Breathing supplemental oxygen produced a small fall in mean exercise ventilation and a large and consistent reduction in mean exercise breathlessness. In seven patients the VAS scores were higher on air than with supplemental oxygen, at similar levels of ventilation. An analysis of co-variance, to control for reduction in ventilation, showed a decrease in mean breathlessness when breathing supplemental oxygen, significant at the 8% level. 4. The reduction in breathlessness produced by preventing exercise desaturation cannot be explained by the decrease in ventilation. This suggests that hypoxia may be a stimulus for breathlessness. The mechanism is unknown.

scholarly journals Improving home oxygen therapy in patients with interstitial lung diseases: application of a noninvasive ventilation device

2020 ◽  
Vol 14 ◽  
pp. 175346662096302
Author(s):  
Sandra Cuerpo ◽  
Maria Palomo ◽  
Fernanda Hernández-González ◽  
Joel Francesqui ◽  
Nuria Albacar ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Noninvasive Ventilation ◽  
Exercise Tolerance ◽  
Oxygen Therapy ◽  
Arterial Oxygen Saturation ◽  
Interstitial Lung Diseases ◽  
Arterial Oxygen ◽  
Chronic Obstructive ◽  
Long Term Oxygen Therapy

Background: Proper adjustment of arterial oxygen saturation (SaO2) during daily activities in patients with interstitial lung disease (ILD) requiring long-term oxygen therapy is challenging. Given the multifactorial nature of the limited exercise tolerance in patients with ILDs, the isolated use of oxygen therapy may not be enough. As demonstrated previously in patients with chronic obstructive pulmonary disease, the use of a noninvasive ventilation (NIV) device combined with oxygen therapy may prevent the falling of oxygen saturation during exercise, due to an improvement of the ventilation–perfusion ratio and a reduction of the respiratory work, thus enhancing exercise tolerance. We sought to assess in patients diagnosed with ILD who are in need of oxygen therapy, the effect of associating an NIV to improve oxygen parameters and the distance covered during the 6 min walking test (6MWT). Methods: We conducted a prospective observational study in patients with ILDs. After a clinical characterization, we performed a 6MWT in two different situations: using a portable oxygen concentrator with the regular flow used by the patient during their daily life activities and afterwards adding the additional support of a NIV. The oxygen saturation parameters were registered with a portable oximeter. Results: We included 16 patients with different ILDs who have oxygen therapy prescribed. The use of NIV associated with oxygen therapy in comparison with the use of oxygen therapy alone showed an increase of the average SaO2 [91% (88–93) versus 88% (86–90%); p = 0.0005] and a decrease in the percentage of time with oxygen saturation <90%: 36% (6–56%) versus 58% (36–77%); p < 0.0001. There were no changes in the 6MWT distance: 307 m (222–419 m) versus 316 m (228–425 m); p = 0.10. Conclusions: In our study the use of a NIV system associated with long-term oxygen therapy during exercise showed beneficial effects, especially improvement of oxygen saturation. The reviews of this paper are available via the supplemental material section.

Arterial oxygen desaturation during treadmill and bicycle exercise in patients with chronic obstructive airways disease

1985 ◽  
Vol 68 (3) ◽  
pp. 327-332 ◽  
Author(s):  
A. Cockcroft ◽  
A. Beaumont ◽  
L. Adams ◽  
A. Guz
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Consumption ◽  
Carbon Dioxide Production ◽  
Arterial Oxygen ◽  
Chronic Obstructive ◽  
Bicycle Exercise ◽  
Arterial Lactate ◽  
Exercise Ventilation ◽  
Obstructive Airways Disease ◽  
Chronic Obstructive Airways Disease

1. Nine men with severe chronic obstructive airways disease (COAD), known to desaturate on exercise, performed a 6 min self-paced walk on a treadmill, followed by a bicycle exercise with workloads adjusted to mimic the oxygen consumption achieved on the treadmill. During both exercises, ventilation, oxygen consumption, carbon dioxide production, Pao2, Paco2, pH and arterial lactate were measured and subjective breathlessness recorded. 2. A reasonable match of oxygen consumption between the two exercises was achieved. In all subjects Pao2 fell to a lower level during treadmill compared with bicycle exercise. Ventilation, carbon dioxide production and arterial lactate were higher during bicycle exercise. Subjective breathlessness was greater during bicycle exercise, in proportion to the higher ventilation on the bicycle. 3. The greater anaerobiosis occurring on the bicycle led to acidosis and an increased ventilation, minimizing the exercise fall in Pao2. 4. Bicycle testing may seriously underestimate exercise desaturation occurring during level walking in patients with severe COAD.

Sign in / Sign up

Export Citation Format

Share Document