The Effect of Arginine Vasopressin on Ureogenesis in Isolated Rat Hepatocytes

1985 ◽  
Vol 68 (s11) ◽  
pp. 48P-49P
Author(s):  
P.J.T. Drew ◽  
H.K. Metcalfe ◽  
J.P. Monson ◽  
R.A. Iles ◽  
R.D. Cohen
1985 ◽  
Vol 69 (2) ◽  
pp. 231-233 ◽  
Author(s):  
P. J. T. Drew ◽  
J. P. Monson ◽  
H. K. Metcalfe ◽  
S. J. W. Evans ◽  
R. A. Iles ◽  
...  

1. The effect of arginine vasopressin (AVP) on ureagenesis was measured in isolated rat hepatocytes with ammonium chloride and l(+)-lactate as substrates. 2. AVP was found to stimulate urea synthesis and the dose-response curve suggests that such an effect is present at concentrations of the hormone as low as 25-50 pmol/l. 3. Both the dose-response curve and the concentrations of NH4+ employed suggest that the effect observed could be of physiological significance.


1979 ◽  
Vol 254 (18) ◽  
pp. 8841-8846
Author(s):  
L.J. Debeer ◽  
J. Thomas ◽  
P.J. De Schepper ◽  
G.P. Mannaerts

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