The Influence of Dietary Potassium Supplementation on the Development of Hypertension in the Spontaneously Hypertensive Rat (SHR)

1984 ◽  
Vol 66 (6) ◽  
pp. 67P.1-67P
Author(s):  
A. Louise Sugden ◽  
Barbara L. Bean
Keyword(s):  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Potassium Supplementation ◽  
Hypertensive Rat ◽  
Dietary Potassium

Effect of dietary potassium chloride in borderline hypertensive rats.

1992 ◽  
Vol 3 (2) ◽  
pp. 188-195
Author(s):  
G F DiBona ◽  
S Y Jones
Keyword(s):  
Sodium Chloride ◽  
Environmental Stress ◽  
Potassium Chloride ◽  
Spontaneously Hypertensive Rat ◽  
Dietary Sodium ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Dietary Potassium ◽  
Sodium Chloride Intake

The borderline hypertensive rat is the first filial offspring of the spontaneously hypertensive rat and the Wistar-Kyoto rat. With increased dietary sodium chloride intake, the borderline hypertensive rat develops hypertension and exaggerated cardiovascular and renal responses to acute environmental stress, similar to those observed in the hypertensive spontaneously hypertensive rat parent. In other models of sodium chloride-sensitive hypertension with different genetic background (Dahl rat), dietary potassium chloride supplementation protects against the development of hypertension, increased sympathetic nervous system activity, and exaggerated responses to acute environmental stress. This investigation sought to determine whether the dietary sodium chloride-induced development of both the hypertension and the exaggerated responses to acute environmental stress could be reversed or prevented by increased dietary potassium chloride intake. Dietary potassium chloride intake was increased with a 1% potassium chloride drinking solution either after 12 wk of 8% sodium chloride intake (reversal) or concomitant with the onset of 12 wk of 8% sodium chloride intake (prevention). An increase in dietary potassium chloride intake did not reverse or prevent the development of either the hypertension or the exaggerated cardiovascular and renal responses to acute environmental stress in borderline hypertensive rats fed 8% sodium chloride. It is concluded that the difference in genetic background between borderline hypertensive rats and other models of sodium chloride-sensitive hypertension is an important determinant of the protective effect of dietary potassium chloride supplementation.

A Linkage Analysis of the Salt-sensitive Hypertensive Gene in the Stroke-prone Spontaneously Hypertensive Rat (SHRSP)

1996 ◽  
Vol 37 (4) ◽  
pp. 553-553
Author(s):  
Tomoji Mashimo ◽  
Yasuo Nara ◽  
Tomoko Tamada ◽  
Chiho Matsumoto ◽  
Katumi Ikeda ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

NHE-1 Protein in Vascular Smooth Muscle and Lymphocytes From the Spontaneously Hypertensive Rat

Hypertension ◽  
1997 ◽  
Vol 30 (4) ◽  
pp. 880-885 ◽  
Author(s):  
Michael S. LaPointe ◽  
Minghao Ye ◽  
Robert Bacallao ◽  
Daniel Batlle
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat
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