Evidence of Altered Structure of the Erythrocyte Membrane in Spontaneously Hypertensive Rats

1982 ◽  
Vol 63 (1) ◽  
pp. 43-45 ◽  
Author(s):  
S. N. Orlov ◽  
P. V. Gulak ◽  
I. S. Litvinov ◽  
YU. V. Postnov
Keyword(s):  
Arterial Hypertension ◽  
Erythrocyte Membrane ◽  
Fluorescent Probes ◽  
Membrane Structure ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hydrophobic Areas ◽  
Renal Hypertensive Rats ◽  
Normotensive Control

1. The membrane structure of erythrocytes of rats with different forms of arterial hypertension was studied by means of two hydrophobic fluorescent probes (diphenylhexatriene and pyrene). 2. Microviscosity of hydrophobic areas of erythrocyte membrane of spontaneously hypertensive rats was found to be increased compared with that of membranes from normotensive control rats. 3. No alterations of membrane structure of erythrocytes of deoxycorticosterone-treated rats and renal hypertensive rats were found.

Decreased Phosphorylation of Polyphosphoinositides in the Erythrocyte Membrane of Spontaneously Hypertensive Rats

1982 ◽  
Vol 63 (s8) ◽  
pp. 37s-39s ◽  
Author(s):  
P. Marche ◽  
S. Koutouzov ◽  
P. Meyer
Keyword(s):  
Erythrocyte Membrane ◽  
Calcium Binding ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto Rats ◽  
Inositol Phospholipids ◽  
Wistar Kyoto

1. The distribution and metabolism of inositol phospholipids were studied in the erythrocyte membrane of spontaneously hypertensive and normotensive Wistar-Kyoto rats. The incorporation of 32P into these lipids was considered as an index of their turnover, and a reflection of their metabolism. 2. With [γ-32P]ATP as the source of label only the polyphosphoinositides (diphosphoinositide and triphosphoinositide) incorporated 32P. The levels of labelling were lower in hypertensive than in normotensive rats. Our data indicate that, in the hypertensive rats, the kinases responsible for the labelling of polyphosphoinositides exhibited decreased Vmax. for ATP. 3. These changes may be related to those described for calcium binding and transport in the erythrocyte of spontaneously hypertensive rats.

Cerebral artery responses to pressure and flow in uremic hypertensive and spontaneously hypertensive rats

2003 ◽  
Vol 284 (4) ◽  
pp. H1212-H1216 ◽  
Author(s):  
D. I. New ◽  
A. M. S. Chesser ◽  
R. C. Thuraisingham ◽  
M. M. Yaqoob
Keyword(s):  
Blood Flow ◽  
Cerebral Artery ◽  
Spontaneously Hypertensive Rats ◽  
Perfusion Pressure ◽  
Hypertensive Rats ◽  
Independent Manner ◽  
Spontaneously Hypertensive ◽  
Cerebral Blood Flow Autoregulation ◽  
Wistar Kyoto ◽  
Normotensive Control

Impaired cerebral blood flow autoregulation is seen in uremic hypertension, whereas in nonuremic hypertension autoregulation is shifted toward higher perfusion pressure. The cerebral artery constricts in response to a rise in either lumen pressure or flow; we examined these responses in isolated middle cerebral artery segments from uremic Wistar-Kyoto rats (WKYU), normotensive control rats (WKYC), and spontaneously hypertensive rats (SHR). Pressure-induced (myogenic) constriction developed at 100 mmHg; lumen flow was then increased in steps from 0 to 98 μl/min. Some vessels were studied after endothelium ablation. Myogenic constriction was significantly lower in WKYU (28 ± 2.9%) compared with both WKYC (39 ± 2.5%, P = 0.035) and SHR (40 ± 3.1%, P = 0.018). Flow caused constriction of arteries from all groups in an endothelium-independent manner. The response to flow was similar in WKYU and WKYC, whereas SHR displayed increased constriction compared with WKYU ( P < 0.001) and WKYC ( P < 0.001). We conclude that cerebral myogenic constriction is decreased in WKYU, whereas flow-induced constriction is enhanced in SHR.

Effect of lysergic acid diethylamide and its brom analogue on arterial hypertension in the rat

1961 ◽  
Vol 201 (6) ◽  
pp. 1131-1133 ◽  
Author(s):  
Stephen Sugaar ◽  
George H. Fried ◽  
John Kalberer ◽  
William Antopol
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Subcutaneous Administration ◽  
Absolute Magnitude ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Normal Blood Pressure ◽  
Hypertensive Rats ◽  
Renal Hypertensive Rats ◽  
Normotensive Control

Subcutaneous administration of d-lysergic acid diethylamide (LSD) or 2-brom- d-lysergic acid diethylamide (BOL) markedly lowered the blood pressure of renal hypertensive rats. Drops of 50–120 mm Hg below established hypertensive blood pressure levels occurred within 48 hr after drug administration. For the following 10–14 days the pressure fluctuated, and then returned to original hypertensive levels. In normotensive control rats fluctuations of lesser absolute magnitude occurred within normal blood pressure ranges.

Calcium Accumulation and Calcium Binding by the Cell Membranes of Cardiomyocytes and Smooth Muscle of Aorta in Spontaneously Hypertensive Rats

1980 ◽  
Vol 59 (s6) ◽  
pp. 207s-209s ◽  
Author(s):  
S. N. Orlov ◽  
Yu. V. Postnov
Keyword(s):  
Smooth Muscle ◽  
Erythrocyte Membrane ◽  
Calcium Binding ◽  
Spontaneously Hypertensive Rats ◽  
Plasma Membranes ◽  
Hypertensive Rats ◽  
Binding Ability ◽  
Spontaneously Hypertensive ◽  
Aortic Smooth Muscle ◽  
Lower Ability

1. The ability of isolated membrane fractions of cardiomyocytes, aortic smooth muscle and erythrocytes from spontaneously hypertensive rats to bind calcium was investigated isotopically. 2. Plasma membranes of aortic smooth muscle and erythrocytes of spontaneously hypertensive rats possess a lower calcium-binding ability than preparations from normotensive controls. 3. Sarcoplasmic reticulum from the myocardium of spontaneously hypertensive rats had a lower ability to accumulate calcium. 4. Changes in the calcium-binding ability of the erythrocyte membrane of spontaneously hypertensive rats was related to the diminution of the amount of exchangeable calcium on the inner part of the membrane. The latter may be the cause of the increase of erythrocyte membrane permeability for sodium in spontaneously hypertensive rats and in patients with essential hypertension.

Cardiovascular Responses to Acute Mental ‘Stress’ in Spontaneously Hypertensive Rats

1973 ◽  
Vol 45 (s1) ◽  
pp. 131s-133s ◽  
Author(s):  
B. Folkow ◽  
Margareta Hallbäck ◽  
Lilian Weiss
Keyword(s):  
Mental Stress ◽  
Spontaneously Hypertensive Rats ◽  
Cardiovascular Responses ◽  
Hypertensive Rats ◽  
Defence Reaction ◽  
Spontaneously Hypertensive ◽  
Emotional Behaviour ◽  
Normotensive Control

1. The hypothalamic defence reaction was assessed in spontaneously hypertensive rats (SHR) and normotensive control rats (NCR). 2. SHR exhibited an apparently true hyper-reactivity of central autonomic structures mediating emotional behaviour during mental stress present in early as well as in established hypertension. 3. This hyper-reactivity is thought, therefore, to be a genetically linked factor predisposing to hypertension in SHR, rather than a consequence of the hypertensive state.

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