Type I Collagen Synthesis in Cultured Aortic Smooth Muscle Cells from Spontaneously Hypertensive Rats and Normotensive Control, Wistar-Kyoto Rats

Pathobiology ◽  
1993 ◽  
Vol 61 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Masumi Akita ◽  
Eiko Murata ◽  
C. Schröter-Kermani ◽  
H.J. Merker
Keyword(s):  
Smooth Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Collagen Synthesis ◽  
Type I Collagen ◽  
Type I ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Aortic Smooth Muscle ◽  
Wistar Kyoto ◽  
Normotensive Control

scholarly journals Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats

2015 ◽  
Vol 36 (4) ◽  
pp. 1453-1466 ◽  
Author(s):  
Marcelo D.M. Cezar ◽  
Ricardo L. Damatto ◽  
Luana U. Pagan ◽  
Aline R.R. Lima ◽  
Paula F. Martinez ◽  
...  
Keyword(s):  
Heart Failure ◽  
Spontaneously Hypertensive Rats ◽  
Type I Collagen ◽  
Myocardial Function ◽  
Type I ◽  
Hypertensive Rats ◽  
Collagen Concentration ◽  
Cross Sectional ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto

Background: We evaluated the role of the aldosterone blocker spironolactone in attenuating long-term pressure overload-induced cardiac remodeling and heart failure (HF) in spontaneously hypertensive rats (SHR). Methods and Results: Thirteen month-old male SHR were assigned to control (SHR-C, n=20) or spironolactone (SHR-SPR, 20 mg/kg/day, n=24) groups for six months. Normotensive Wistar-Kyoto rats (WKY, n=15) were used as controls. Systolic blood pressure was higher in SHR groups and unchanged by spironolactone. Right ventricular hypertrophy, which characterizes HF in SHR, was less frequent in SHR-SPR than SHR-C. Echocardiographic parameters did not differ between SHR groups. Myocardial function was improved in SHR-SPR compared to SHR-C [developed tension: WKY 4.85±0.68; SHR-C 5.22±1.64; SHR-SPR 6.80±1.49 g/mm2; -dT/dt: WKY 18.0 (16.0-19.0); SHR-C 20.8 (18.4-25.1); SHR-SPR 28.9 (24.2-34.6) g/mm2/s]. Cardiomyocyte cross-sectional area and total collagen concentration (WKY 1.06±0.34; SHR-C 1.85±0.63; SHR-SPR 1.28±0.39 µg/mg wet tissue) were greater in SHR-C than WKY and SHR-SPR. Type 3 collagen expression was lower in SHR-C than WKY and unchanged by spironolactone. Soluble collagen, type I collagen, and lysyl oxidase did not differ between groups. Conclusion: Early spironolactone treatment decreases heart failure development frequency by improving myocardial systolic and diastolic function and attenuating hypertrophy and fibrosis in spontaneously hypertensive rats.

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