The Effect of the Methionine Enkephalin Analogue DAMME on the Vasopressin Response to Tilt in Man

1980 ◽  
Vol 59 (6) ◽  
pp. 501-503 ◽  
Author(s):  
S. L. Lightman ◽  
Mary L. Forsling
Keyword(s):  
Blood Pressure ◽  
Pulse Rate ◽  
Plasma Volume ◽  
Arginine Vasopressin ◽  
Pressure Pulse ◽  
Volume Changes ◽  
Methionine Enkephalin ◽  
Head Up Tilt ◽  
Plasma Arginine

1. Infusion of the methionine enkephalin analogue DAMME (Sandoz) inhibits the rise in plasma arginine vasopressin after a 65° head-up tilt. 2. DAMME does not significantly affect the blood pressure, pulse rate or plasma volume changes produced by tilt.

Inhibition of plasma vasopressin after drinking in dehydrated humans

1984 ◽  
Vol 247 (6) ◽  
pp. R968-R971 ◽  
Author(s):  
G. Geelen ◽  
L. C. Keil ◽  
S. E. Kravik ◽  
C. E. Wade ◽  
T. N. Thrasher ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Volume ◽  
Arginine Vasopressin ◽  
Tap Water ◽  
Renin Activity ◽  
Plasma Vasopressin ◽  
Rapid Fall ◽  
Before And After ◽  
Plasma Arginine

To study the effects of nonosmotic and nonvolumetric factors that may influence secretion of vasopressin, serum Na+, K+, and osmolality (Osm), hemoglobin, hematocrit, plasma arginine vasopressin (AVP), aldosterone (PA), and renin activity (PRA) were measured in five men and three women (26–50 yr, 73 +/- 4 kg) before and after 24 h of mild dehydration (food but no fluid) and seven times during the 1st h after rehydration with 10 ml/kg of tap water (17.5 +/- 0.5 degrees C) consumed in 105 s (range 35-240 s). Dehydration increased mean serum Na+ 3.7 +/- 0.7 meq/l (P less than 0.05), osmolality 9.1 +/- 1.1 mosmol/kg (P less than 0.05), and AVP from a hydrated level of 1.7 +/- 0.2 to 3.3 +/- 0.5 pg/ml (delta = 1.6 pg/ml, P less than 0.05). After rehydration AVP fell to 2.4 +/- 0.3 pg/ml (P less than 0.05) within 3 min and reached the water-replete level of 1.8 +/- 0.3 pg/ml 9 min after drinking started. Serum Na+ and Osm did not change until 30–60 min after drinking. No significant changes occurred in PRA, hemogloblin, hematocrit, or calculated delta in plasma volume, but PA increased from 11.1 +/- 1.5 ng/dl after dehydration to 15.6 +/- 2.6 ng/dl (P less than 0.05) between 30 and 60 min after drinking. The rapid fall in plasma AVP after rehydration took place in the absence of the expected changes in the primary regulators of plasma AVP (i.e., osmolality and plasma volume), with no change in blood pressure. The results suggest that oropharyngeal factors, alone or combined with gastric stimuli, are implicated.

The Reflex Control of Arginine-Vasopressin Release in Essential Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 145s-147s ◽  
Author(s):  
B. Ricciardelli ◽  
M. Volpe ◽  
B. Trimarco ◽  
M. Chiariello ◽  
F. Rengo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arginine Vasopressin ◽  
Carotid Sinus ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Vasopressin Release ◽  
Head Up Tilt ◽  
Reflex Control ◽  
Plasma Arginine ◽  
Neck Chamber

1. The reflex control of arginine-vasopressin release was studied in 12 essential established hypertensive patients and in 12 age-matched normal subjects by comparing the effects of head-up tilt and a variable-pressure neck-chamber. 2. After 45 min 85° head-up tilt, normal subjects showed an increase in plasma arginine-vasopressin and in plasma renin activity, while plasma volume decreased. In hypertensive patients, plasma arginine-vasopressin showed changes after tilt opposite to those of controls, while the changes in plasma renin activity and plasma volume were similar to those observed in the normal group. In both groups the changes in systolic and diastolic blood pressure were not statistically significant. A reduction in carotid sinus transmural pressure obtained by increasing neck-tissue pressure (+ 50 mmHg) by means of a neck-chamber, evoked different responses in mean blood pressure in the two groups, but failed to induce any significant change in plasma arginine-vasopressin concentration both in the normal and in the hypertensive subjects. 3. These results seem to suggest that carotid sinus baroreceptors, though active in blood pressure control, do not play a direct role in arginine-vasopressin release and, therefore, the opposite response of arginine-vasopressin observed after tilt in the two groups of subjects should be ascribed to more complex mechanisms.

Haemodynamic Changes Associatedc with Obesity and High Blood Pressure in Crats with Ventromedial Hypothalamic Lesions

1980 ◽  
Vol 59 (s6) ◽  
pp. 397s-399s ◽  
Author(s):  
E. Reisin ◽  
D. H. Suarez ◽  
E. D. Frohlich
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
High Blood Pressure ◽  
Plasma Volume ◽  
Mild Hypertension ◽  
Male Rats ◽  
Volume Changes ◽  
Hypothalamic Lesions ◽  
Haemodynamic Changes ◽  
Mild Obesity

1. The haemodynamic and plasma volume changes associated with obesity and high blood pressure were studied in nine male rats with electrolytic ventromedial hypothalamic lesions and their paired sham-operated controls. Body weight and arterial pressure were greater in the rats with ventromedial hypothalamic lesions (565 ± 16 vs 462 ± 14 g, P<0.001; 128 ± 3 vs 118 ± 3 mmHg, P<0.05, respectively). Cardiac output was slightly elevated, and that portion of cardiac output distributed to the kidneys was reduced (P<0.001). Plasma volume was contracted in the rats with ventromedial hypothalamic lesions (21.0 ± 0.1 vs 2.8 ± 0.1 ml/100 g, P<0.001). 2. The haemodynamic characteristics of rats in which obesity and mild hypertension have been induced by electrolytic ventromedial hypothalamic lesion are similar to mild obesity essential hypertension in men.

Effects of an Inverted Position on Blood Pressure, Pulse Rate, and Deep Tendon Reflexes of Healthy Young Adults

1985 ◽  
Vol 65 (9) ◽  
pp. 1358-1362
Author(s):  
Wendy Rheault ◽  
Martha Derleth ◽  
Mary Casey ◽  
Charity Czarnik ◽  
Donna Kania ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Pulse Rate ◽  
Pressure Pulse ◽  
Inverted Position ◽  
Tendon Reflexes

scholarly journals BIOLOGICAL RISK PROFILES IN THE OLDER MEXICAN POPULATION

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S788-S788
Author(s):  
Catherine Garcia ◽  
Joseph Saenz ◽  
Jennifer A Ailshire ◽  
Rebecca Wong ◽  
Eileen M Crimmins
Keyword(s):  
Blood Pressure ◽  
High Risk ◽  
Pulse Rate ◽  
Mexican Americans ◽  
Pressure Pulse ◽  
Glycosylated Hemoglobin ◽  
Hdl Cholesterol ◽  
Underlying Disease ◽  
Biological Risk ◽  
Logistic Regression Models

Abstract Research examining biological risk is critical given that both the Mexican and U.S. populations are aging. Biomarkers can help us understand underlying disease patterns among Mexican-origin individuals in Mexico and the U.S. to help inform disease-prevention efforts for these populations. Using data from the 2012 Mexican Health and Aging Study and the 2010/2012 Health and Retirement Study, we examine seven biomarkers known to predict health risk: systolic and diastolic blood pressure, pulse rate, total cholesterol, HDL cholesterol, glycosylated hemoglobin, and C-reactive protein. Logistic regression models, controlling for age and sex, are used to predict high-risk for each biomarker among Mexico-born Mexicans, Mexico-born Mexican-Americans, and U.S.-born Mexican-Americans. Results show that Mexico-born Mexicans exhibit higher biological risk for systolic blood pressure, pulse rate, low HDL cholesterol, glycosylated hemoglobin, and inflammation than Mexico-born and U.S.-born Mexican-Americans. Additionally accounting for socioeconomic status and health behaviors did not explain differences in high-risk among Mexican-born Mexicans.

Increased cardiovascular response to caffeine in perimenopausal women before and during estrogen therapy

1996 ◽  
Vol 135 (5) ◽  
pp. 598-603 ◽  
Author(s):  
G Del Rio ◽  
R Menozzi ◽  
G Zizzo ◽  
A Avogaro ◽  
P Marrama ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Diastolic Blood Pressure ◽  
Pulse Rate ◽  
Pressure Pulse ◽  
Cardiovascular Response ◽  
Estrogen Therapy ◽  
Premenopausal Women ◽  
Perimenopausal Women ◽  
Del Rio

Del Rio G, Menozzi R, Zizzo G, Avogaro A, Marrama P, Velardo A. Increased cardiovascular response to caffeine in perimenopausal women before and during estrogen therapy. Eur J Endocrinol 1996; 135:598–603. ISSN 0804–4643 Perimenopause and menopause may be associated with an increased risk of cardiovascular disease, so we have investigated the cardiovascular and catecholamine response to caffeine in perimenopausal women compared to young cycling premenopausal subjects. Caffeine (250 mg per os) was administered to nine perimenopausal women and nine premenopausal women. The perimenopausal women repeated the test after 4 months of percutaneous estrogen replacement therapy. Systolic and diastolic blood pressure, pulse rate, plasma norepinephrine, epinephrine, glucose, insulin and free fatty acids were determined at 0, 15, 30, 45, 60, 90 and 120 min after caffeine administration. No differences were found in the basal values of systolic blood pressure, diastolic blood pressure, pulse rate, norepinephrine, epinephrine, insulin, glucose and free fatty acids between perimenopausal women, both before and after therapy, and premenopausal women. Caffeine induced a higher increase of systolic (F = 4.9; p < 0.05) and diastolic blood pressure (F = 4.7; p < 0.05) in perimenopausal women before and during estrogen therapy as compared with premenopausal women. Pulse rate increased significantly only in perimenopausal women before therapy (F = 6.5; p < 0.03). These data show that perimenopause either before or during short-term estrogen therapy is associated with enhanced cardiovascular reactivity to caffeine. This phenomenon is not due to increased adrenergic and metabolic responses. Graziano Del Rio, Department of Internal Medicine via del Pozzo, 71 41100 Modena, Italy

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