The Effect of Chronic Alteration of Sodium and Potassium Intake on Blood Pressure and Plasma Renin Activity, Aldosterone and Noradrenaline in Mild Essential Hypertension

1980 ◽  
Vol 59 (3) ◽  
pp. 2P-2P
Author(s):  
P. S. Parfrey ◽  
M. J. Vandenburg ◽  
P. Wright ◽  
J. M. P. Holly ◽  
F. J. Goodwin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Potassium Intake ◽  
Sodium And Potassium

Solitary Kidney and Ageing as Causes of Low Renin and Aldosterone Concentrations: Relevance to ‘Low-Renin’ Essential Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 177s-180s ◽  
Author(s):  
R. Gordon ◽  
Freda Doran ◽  
M. Thomas ◽  
Frances Thomas ◽  
P. Cheras
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Plasma Volume ◽  
Plasma Renin ◽  
Renin Activity ◽  
Dietary Sodium ◽  
Sodium Restriction ◽  
Normotensive Subjects ◽  
The Mean

1. As experimental models of reduced nephron population in man, (a) twelve men aged 15–32 years who had one kidney removed 1–13 years previously and (b) fourteen normotensive men aged 70–90 years were studied. Results were compared with those in eighteen normotensive men aged 18–28 years and eleven men aged 19–33 years with essential hypertension. 2. While the subjects followed a routine of normal diet and daily activity, measurements were made, after overnight recumbency and in the fasting state, of plasma volume and renin activity on one occasion in hospital and of blood pressure on five to fourteen occasions in the home. Blood pressure was also measured after standing for 2 min and plasma renin activity after 1 h standing, sitting or walking. Twenty-four hour urinary aldosterone excretion was also measured. 3. The measurements were repeated in the normotensive subjects and subjects in (a) and (b) above after 10 days of sodium-restricted diet (40 mmol of sodium/day). 4. The mean plasma renin activity (recumbent) in essential hypertensive subjects was higher than in normotensive subjects. In subjects of (a) and (b) above, it was lower than normotensive subjects, and was not increased by dietary sodium restriction in subjects of (a). 5. The mean aldosterone excretion level was lower in old normotensive subjects than in the other groups, and increased in each group after dietary sodium restriction. 6. Mean plasma volume/surface area was not different between the four groups and in normotensive, essential hypertensive and nephrectomized subjects but not subjects aged 70–90 years was negatively correlated with standing diastolic blood pressure.

Effect of Atenolol(Tenormin®) on Blood Pressure and Plasma Renin Activity in Essential Hypertension

1982 ◽  
Vol 12 (1) ◽  
pp. 145
Author(s):  
Soon Kyu Suh ◽  
Sae Wha Yoo ◽  
Soon Chang Park ◽  
Joon Sock Kim ◽  
Kyung Ho Kang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity

scholarly journals Evaluation of plasma renin activity by blood pressure level (pressure-renin index) in patients with essential hypertension.

1982 ◽  
Vol 46 (9) ◽  
pp. 954-963 ◽  
Author(s):  
YASUHIRO NODA ◽  
KOSHIRO FUKIYAMA ◽  
KENSHI KUMAMOTO ◽  
SHUICHI TAKISHITA ◽  
TERUKAZU KAWASAKI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Blood Pressure Level ◽  
Plasma Renin ◽  
Pressure Level ◽  
Renin Activity ◽  
Level Pressure

The Effect of Mineralocorticoid Administration on Urine Free Dopamine in Man

1980 ◽  
Vol 58 (1) ◽  
pp. 77-82 ◽  
Author(s):  
N. S. Oates ◽  
C. M. Perkins ◽  
M. R. Lee
Keyword(s):  
Plasma Renin Activity ◽  
Chloride Concentration ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Sodium Concentration ◽  
Renin Activity ◽  
Potassium Intake ◽  
Metabolic Conditions ◽  
Renal Dopamine ◽  
Sodium And Potassium

1. Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0·2 mg twice daily). 3. Urine free dopamine showed a tendency to fall during the early phase of fludrocortisone administration and then rose towards normal. 4. In a patient with primary hyperaldosteronism there was no evidence of increased renal production of dopamine. Urine dopamine fell when plasma renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days). 5. If renal dopamine has a role in mineralocorticoid ‘escape’ then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular chloride concentration and intrarenal renin activity.

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