Effects of Adrenaline Injection on Human Plasma Tryptophan and Non-Esterified Fatty Acids

1977 ◽  
Vol 53 (3) ◽  
pp. 227-232 ◽  
Author(s):  
V. Gentil ◽  
M. H. Lader ◽  
B. D. Kantamaneni ◽  
G. Curzon
Keyword(s):  
Fatty Acids ◽  
Psychiatric Illness ◽  
Male Volunteer ◽  
Normal Male ◽  
Plasma Tryptophan ◽  
Plasma Phenylalanine ◽  
Free Tryptophan ◽  
Esterified Fatty Acids ◽  
Plasma Tyrosine ◽  
Adrenaline Injection

1. Subcutaneous injection of adrenaline into normal male volunteer subjects caused large increases of plasma non-esterified fatty acids and free tryptophan, but plasma total tryptophan fell considerably. Therefore increases of the percentage of plasma tryptophan in the free state were more marked than absolute increases of free tryptophan. 2. Plasma tyrosine fell slightly and plasma phenylalanine and cortisol were unaffected. 3. It is suggested that catecholamine release could lead to abnormalities of tryptophan disposition in stress and psychiatric illness.

The Daily Rhythm of Plasma Tryptophan and Tyrosine in Depression

1976 ◽  
Vol 128 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Pekka Niskanen ◽  
Matti Huttunen ◽  
Tapani Tamminen ◽  
Juha Jääskeläinen
Keyword(s):  
Control Group ◽  
Total Plasma ◽  
Plasma Tryptophan ◽  
Free Tryptophan ◽  
The Times ◽  
Plasma Tyrosine ◽  
Depressive Patients ◽  
The Brain ◽  
Free Plasma ◽  
Tryptophan Level

SummaryThe study dealt with the level of and diurnal alterations in the concentration of tryptophan, free tryptophan and tyrosine in the blood plasma of 20 inhibited depression patients and 10 healthy controls.The results suggested that there was no distinct relationship between either the total plasma tryptophan or plasma tyrosine level and depression. On the other hand, the free plasma tryptophan level was, at all the times of day at which measurements were made, either significantly or almost significantly higher in the patients than in the controls. It was further found that the results of measurement were related to the patients’ clinical improvement, as measured by the Hamilton test, in such a way that after four weeks of treatment the free plasma tryptophan level in ‘poorly improved’ patients continued to be significantly higher in comparison with the controls, whereas the values for the ‘well improved’ patient group did not differ greatly from the corresponding values for the control group any longer.It may be hypothesized that the rise in the free plasma tryptophan in depressive patients might represent an effort made by the peripheral body to compensate for the slowed-up serotonin metabolism of the brain, whereby the tryptophan mobilized from the periphery would serve as a sort of ‘endogenous antidepressant’ provided by the organism itself.

scholarly journals The effects of diet, lipolysis and limb ischaemia on the distribution of plasma tryptophan in the rat

1975 ◽  
Vol 146 (3) ◽  
pp. 659-666 ◽  
Author(s):  
H B Stoner ◽  
V J Cunningham ◽  
P M Elson ◽  
A Hunt
Keyword(s):  
Fatty Acid ◽  
Acid Concentration ◽  
Fatty Acid Concentration ◽  
Limb Ischaemia ◽  
Plasma Tryptophan ◽  
Free Tryptophan ◽  
Esterified Fatty Acids ◽  
Tryptophan Concentration ◽  
Free Plasma ◽  
Sustained Increase

A non-linear relationship between the plasma non-esterified fatty acid concentration and the percentage of free plasma tryptophan was found in rats in different nutritional states, although non-esterified fatty acids are not the only factors determining the percentage of free tryptophan. This relationship was not seen in rats injured by limb ischaemia. The effect of drugs causing rapid increases in the plasma non-esterified fatty acid concentration was also studied. Isoprenaline decreased the total plasma tryptophan concentration. Dichloroisoprenaline caused a sustained increase in the plasma non-esterified fatty acid concentration which was accompanied by an increase in the concentration of free plasma tryptophan and followed by a fall in the concentration of total tryptophan. The loss of tryptophan from the plasma was attributed to an altered distribution of tryptophan in the extracellular space rather than to increased metabolism. This interpretation was supported by determinations of the irreversible disposal rate of plasma tryptophan which in uninjured rats was unaffected by the concentration of free plasma tryptophan. In the injured rats this rate was unaltered during limb ischaemia but was decreased after removal of the tourniquets; increased competition for tissue entry by other neutral amino acids and the fall in body temperature could be factors in this fall.

Effect of Propolis-Supplemented Diet on Body Composition and Endocrine Function of Adipose Tissue

2020 ◽  
Vol 19 (2) ◽  
pp. 217-221
Author(s):  
Maria Jesús Lisbona-González ◽  
Candela Reyes-Botella ◽  
Esther Muñoz-Soto ◽  
Maria Victoria Olmedo-Gaya, ◽  
Jorge Moreno-Fernandez ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Adipose Tissue ◽  
Endocrine Function ◽  
Control Group ◽  
Albino Rats ◽  
Standard Diet ◽  
Reduced Body ◽  
Esterified Fatty Acids ◽  
Wistar Albino Rats

Adipose tissue is an endocrine organ and has central role in interaction with other organs or tissues while propolis can induce lipolysis. Therefore, the aim of this study is to provide detailed information about adipose tissue homeostasis modifications and body composition during propolis supplement consumption. Twenty male Wistar albino rats (8 weeks) were divided into two groups of 10 animals each and fed for 90 days with two different types of diets: standard for the control group (diet C) and standard diet + 2% propolis (diet P). Thyroid hormones did not show differences, while ghrelin and adiponectin decreased in the group that was fed propolis. Insulin, leptin, and non-esterified fatty acids also increased along with reduced body weight and fat, in addition to increased lean mass when propolis was in the diet. We conclude that propolis could decrease ghrelin and adiponectin but increase non-esterified fatty acids and insulin secretion, which improves body composition.

scholarly journals 51 Intranasal oxytocin improves plasma non-esterified fatty acids but not distance walked or cortisol concentrations at weaning

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 29-30
Author(s):  
Kirsten Nickles ◽  
Alejandro E Relling ◽  
Anthony J Parker
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Repeated Measures ◽  
Production Costs ◽  
Calf Growth ◽  
Beef Calves ◽  
Esterified Fatty Acids ◽  
Randomized Design ◽  
Affect Body Weight ◽  
Global Positioning

Abstract Beef calves express behaviors such as walking and vocalizing to a greater extend during weaning. These behaviors increase production costs due to compromised calf growth, health, and welfare. Oxytocin treatment reduces anxious behaviors and attenuates the HPA axis, thus the objective of this experiment was to evaluate the effects of oxytocin on calf growth, cortisol, and distance walked at weaning. A total of 20 Angus x Simmental heifer calves were randomly allotted to each treatment group (n = 10), intranasal oxytocin or saline (OXT, CON). All calves were administered the respective intranasal treatment at weaning (day 0), and then placed in the same pasture. Calves were weighed and blood sampled on days 0, 1, 7, and 14. Blood samples were used to quantify non-esterified fatty acids (NEFA), β-hydroxybutyrate, and cortisol. Each heifer was fitted with a global positioning system collar that recorded calf location every 10 seconds for 16 h on days 0, 7, and 14. To further evaluate calf behavior, observations were made on days 0, 7, and 14 using instantaneous scan sampling from 0730 to 0830, 1200 to 1300, and 1700 to 1800 h. Data were analyzed using a completely randomized design with repeated measures model (SAS 9.4). Providing calves with intranasal oxytocin on the day of weaning did not have an effect on the distance walked, observed behavior, body weight, β-hydroxybutyrate, or cortisol concentrations, however, there was a day effect (P < 0.05) for these variables. Intranasal oxytocin treatment did affect NEFA concentrations, as calves in the CON group had greater NEFA concentrations on day 1 compared with calves in the OXT group (P < 0.05). These data imply that intranasal oxytocin could have the capacity to decrease mobilization of NEFA, but this change was not enough to affect body weight 14 days after weaning.

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