scholarly journals The effects of diet, lipolysis and limb ischaemia on the distribution of plasma tryptophan in the rat

1975 ◽  
Vol 146 (3) ◽  
pp. 659-666 ◽  
Author(s):  
H B Stoner ◽  
V J Cunningham ◽  
P M Elson ◽  
A Hunt
Keyword(s):  
Fatty Acid ◽  
Acid Concentration ◽  
Fatty Acid Concentration ◽  
Limb Ischaemia ◽  
Plasma Tryptophan ◽  
Free Tryptophan ◽  
Esterified Fatty Acids ◽  
Tryptophan Concentration ◽  
Free Plasma ◽  
Sustained Increase

A non-linear relationship between the plasma non-esterified fatty acid concentration and the percentage of free plasma tryptophan was found in rats in different nutritional states, although non-esterified fatty acids are not the only factors determining the percentage of free tryptophan. This relationship was not seen in rats injured by limb ischaemia. The effect of drugs causing rapid increases in the plasma non-esterified fatty acid concentration was also studied. Isoprenaline decreased the total plasma tryptophan concentration. Dichloroisoprenaline caused a sustained increase in the plasma non-esterified fatty acid concentration which was accompanied by an increase in the concentration of free plasma tryptophan and followed by a fall in the concentration of total tryptophan. The loss of tryptophan from the plasma was attributed to an altered distribution of tryptophan in the extracellular space rather than to increased metabolism. This interpretation was supported by determinations of the irreversible disposal rate of plasma tryptophan which in uninjured rats was unaffected by the concentration of free plasma tryptophan. In the injured rats this rate was unaltered during limb ischaemia but was decreased after removal of the tourniquets; increased competition for tissue entry by other neutral amino acids and the fall in body temperature could be factors in this fall.

The Daily Rhythm of Plasma Tryptophan and Tyrosine in Depression

1976 ◽  
Vol 128 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Pekka Niskanen ◽  
Matti Huttunen ◽  
Tapani Tamminen ◽  
Juha Jääskeläinen
Keyword(s):  
Control Group ◽  
Total Plasma ◽  
Plasma Tryptophan ◽  
Free Tryptophan ◽  
The Times ◽  
Plasma Tyrosine ◽  
Depressive Patients ◽  
The Brain ◽  
Free Plasma ◽  
Tryptophan Level

SummaryThe study dealt with the level of and diurnal alterations in the concentration of tryptophan, free tryptophan and tyrosine in the blood plasma of 20 inhibited depression patients and 10 healthy controls.The results suggested that there was no distinct relationship between either the total plasma tryptophan or plasma tyrosine level and depression. On the other hand, the free plasma tryptophan level was, at all the times of day at which measurements were made, either significantly or almost significantly higher in the patients than in the controls. It was further found that the results of measurement were related to the patients’ clinical improvement, as measured by the Hamilton test, in such a way that after four weeks of treatment the free plasma tryptophan level in ‘poorly improved’ patients continued to be significantly higher in comparison with the controls, whereas the values for the ‘well improved’ patient group did not differ greatly from the corresponding values for the control group any longer.It may be hypothesized that the rise in the free plasma tryptophan in depressive patients might represent an effort made by the peripheral body to compensate for the slowed-up serotonin metabolism of the brain, whereby the tryptophan mobilized from the periphery would serve as a sort of ‘endogenous antidepressant’ provided by the organism itself.

Influence of Dietary Fatty Acid Concentration and Geometric Configuration on Murine Mammary Tumorigenesis and Experimental Metastasis

1984 ◽  
Vol 114 (10) ◽  
pp. 1834-1842 ◽  
Author(s):  
Kent L. Erickson ◽  
Deborah S. Schlanger ◽  
Dorothy A. Adams ◽  
David R. Fregeau ◽  
Judith S. Stern
Keyword(s):  
Fatty Acid ◽  
Acid Concentration ◽  
Mammary Tumorigenesis ◽  
Dietary Fatty Acid ◽  
Geometric Configuration ◽  
Fatty Acid Concentration ◽  
Experimental Metastasis

scholarly journals Fatty Acid Concentration and Phase Transitions Modulate Aβ Aggregation Pathways

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Pratip Rana ◽  
Dexter N. Dean ◽  
Edward D. Steen ◽  
Ashwin Vaidya ◽  
Vijayaraghavan Rangachari ◽  
...  
Keyword(s):  
Phase Transitions ◽  
Fatty Acid ◽  
Acid Concentration ◽  
Fatty Acid Concentration ◽  
Aβ Aggregation

scholarly journals Effects of probiotics on loperamide-induced constipation in rats

2020 ◽  
Author(s):  
Takio Inatomi
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Oral Administration ◽  
Acid Concentration ◽  
Short Chain Fatty Acid ◽  
Phosphate Buffer Solution ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Fatty Acid Concentration ◽  
Sd Rats

AbstractConstipation, a common health problem, causes discomfort and affects quality of life. This study aimed to evaluate the potential effect of probiotics on loperamide (LP)-induced constipation in Sprague-Dawley (SD) rats, a well-established animal model of spastic constipation. In total, 100 male SD rats (age, 8 weeks; Japan SLC, Inc., Hamamatsu, Japan) were used in the experiments following a 12-day acclimatisation period. They were randomly divided into two treatment groups (groups 1 and 2) of 50 rats each. Spastic constipation was induced via oral administration of LP (3 mg/kg) for 6 days 1 hour before the administration of each test compound. Similarly, a probiotics solution (4 ml/kg body weight) was orally administered to the rats once a day for 6 days in group 2. In group 1, phosphate buffer solution was orally administered once a day for 6 days 1 hour after each LP administration. The changes in body weight, faecal parameters, short-chain fatty acid concentration in faeces, and faecal immunoglobulin (Ig)-A concentration were recorded. In the present study, the oral administration of probiotics improved faecal parameters, short-chain fatty acid concentration in faeces, and faecal IgA concentration. Our results indicate that probiotics increase the levels of intestinal short-chain fatty acids, especially butyric acid, thereby improving constipation and intestinal immunity.

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