Bone Necrosis and Urinary Hydroxyproline Excretion in Rabbits

1977 ◽  
Vol 52 (5) ◽  
pp. 523-526 ◽  
Author(s):  
C. R. Weatherley ◽  
G. Dale ◽  
J. McGurk ◽  
D. N. Walder
Keyword(s):  
Deep Sea ◽  
Experimental Production ◽  
Urinary Hydroxyproline ◽  
Aseptic Necrosis ◽  
Bone Necrosis ◽  
Histological Evidence ◽  
Chronic Complication ◽  
Before And After ◽  
Hydroxyproline Excretion ◽  
Early Indication

1. Aseptic necrosis of bone is a serious chronic complication of deep-sea diving and compressed-air work. 2. The changes to the bone which occur in this condition take time to develop to the stage where they cause the radiographic signs of bone necrosis, and consequently there is a delay of some months between the causal incident and the first diagnosis by radiography. 3. As a possible method for the earlier detection of bone necrosis the 24 h urinary excretion of hydroxyproline was measured over a period before and after experimental production of bone necrosis in rabbits by the intra-arterial injection of glass microspheres. 4. Total hydroxyproline excretion rose significantly within a few days of the injection in those rabbits in which there was later shown to be histological evidence of bone necrosis. This rise occurred long before there was any radiographic change. 5. It is suggested that measurement of urinary hydroxyproline might be used to give an early indication of bone necrosis in man.

TOTAL URINARY HYDROXYPROLINE EXCRETION BEFORE AND AFTER HYPOPHYSECTOMY IN PATIENTS WITH BONE METASTASES FROM BREAST CARCINOMA

1968 ◽  
Vol 59 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Jørn Ditzel ◽  
Robert Jordal ◽  
Niels Riskær
Keyword(s):  
Breast Cancer ◽  
Urinary Excretion ◽  
Bone Metastases ◽  
Healthy Subjects ◽  
Serum Alkaline Phosphatase ◽  
Bone Matrix ◽  
Urinary Hydroxyproline ◽  
Before And After ◽  
The Mean ◽  
Hydroxyproline Excretion

ABSTRACT Recent investigations indicate that the urinary excretion of total hydroxyproline is a measure of the metabolism of collagen, particularly the bone matrix. The total hydroxyproline excretion has been determined in 28 women with bone metastases from breast cancer, and in 12 healthy volunteers. In 22 of the 28 cases with bone metastases the urinary excretion of hydroxyproline was measured shortly before and repeated shortly after hypophysectomy. In addition, the measurements were repeated 3 to 12 months after hypophysectomy in 8 of the patients. The mean excretion of hydroxyproline was significantly higher in patients with bone metastases from breast cancer (52.9 mg/24 h) than in healthy subjects (22.1 mg/24 h). A correlation was found between the urinary excretion of hydroxyproline and serum alkaline phosphatase levels. The mean excretion of total hydroxyproline was 51.0 mg/24 h before hypophysectomy and 63.8 mg/24 h after hypophysectomy. This difference is not statistically significant. Determinations of urinary hydroxyproline excretion in patients with breast cancer has not been found of great value in the assessment of the clinical condition of these patients.

Cytocompatibility of Magnesium-Zinc-Calcium Alloys with Bone Marrow Derived Mesenchymal Stem Cells

2014 ◽  
Vol 922 ◽  
pp. 1-6
Author(s):  
Aaron F. Cipriano ◽  
Christopher Miller ◽  
Hui Nan Liu
Keyword(s):  
Biomedical Applications ◽  
Culture Media ◽  
Corrosion Properties ◽  
Cell Culture Media ◽  
Tissue Culture Polystyrene ◽  
Metallic Biomaterials ◽  
Zn Content ◽  
Before And After ◽  
Orthopedic Applications ◽  
Early Indication

Magnesium (Mg)-based alloys have attracted great interest as metallic biomaterials for orthopedic applications due to their biocompatibility, biodegradability, and mechanical properties that resemble those of cortical bone. However, the potential toxicity of alloying elements in commercially available Mg alloys makes it critical to engineer and screen new alloys specifically for biomedical applications. The objective of this study was to evaluate and compare the in vitrodegradation and cytocompatibility of two distinct Mg - Zinc (Zn) - Calcium (Ca) alloys (Mg-4%Zn-1%Ca and Mg-9%Zn-1%Ca, wt. %; abbreviated as ZCa41 and ZCa91, respectively) using a bonemarrow derived mesenchymal stem cell (BMSC) model. Both Zn and Ca play critical roles in boneformation and growth, and have been shown to increase mechanical and corrosion properties of Mgalloys. BMSCs provide vertebrates the continuous supply of osteoblasts needed for bone remodelingand repair, and thus were selected to determine the effect of increasing Zn content on cell behavior.Surface microstructure and composition of the alloys were characterized before and after BMSC culture using field emission scanning electron microscopy (FESEM) and energy dispersive X-rayspectroscopy (EDS). Thermanox® treated glass and plasma treated tissue culture polystyrene were used as a control and reference, respectively. Results indicated that the ZCa91 alloy improved BMSC adhesion as compared with ZCa41 alloy. The formation of high-aspect ratio needle-likefeatures on the surface of ZCa41 alloy after its degradation in cell culture media was speculated tocontribute to the lower cell adhesion. This study provided an early indication on cytocompatibility of Mg-Zn-Ca alloys for biomedical applications.

Urinary Hydroxyproline Excretion in Normal Children and Adolescents.

1964 ◽  
Vol 115 (1) ◽  
pp. 85-87 ◽  
Author(s):  
C. R. Jones ◽  
M. W. Bergman ◽  
P. J. Kittner ◽  
W. W. Pigman
Keyword(s):  
Children And Adolescents ◽  
Urinary Hydroxyproline ◽  
Normal Children ◽  
Hydroxyproline Excretion

Skeletal Blood Flow in Paget's Disease of Bone and its Response to Calcitonin Therapy

1978 ◽  
Vol 54 (1) ◽  
pp. 69-74 ◽  
Author(s):  
R. Wootton ◽  
J. Reeve ◽  
E. Spellacy ◽  
M. Tellez-Yudilevich
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Flow ◽  
Serum Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Short Term ◽  
Urinary Hydroxyproline ◽  
Rapid Fall ◽  
Hydroxyproline Excretion

1. Blood flow to the skeleton was measured by the 18F clearance method of Wootton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxyproline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.

scholarly journals Aseptic (avascular) bone necrosis in the foot and ankle

2020 ◽  
Vol 5 (10) ◽  
pp. 684-690
Author(s):  
Xavier Martin Oliva ◽  
Antonio Viladot Voegeli
Keyword(s):  
Metatarsophalangeal Joint ◽  
Growth Period ◽  
Common Denominator ◽  
Loose Bodies ◽  
Disease Treatment ◽  
Aseptic Necrosis ◽  
Bone Necrosis ◽  
Tarsal Bones ◽  
Advanced Stages ◽  
Talar Fractures

Aseptic necrosis may be defined as a group of diseases that have bone necrosis as a common denominator. They usually appear in the epiphyses and in the carpal and tarsal bones. They generally appear during a growth period and principally at those skeletal points subjected to particular stress. In Müller–Weiss disease in the advanced stages, talonavicular-cuneiform arthrodesis, with or without back foot correction, is the best surgical option. In Freiberg–Kohler disease, treatment can be conservative and we can maintain the head of the metatarsal by performing a joint debridement of the metatarsophalangeal joint with removal of loose bodies. The lateral upper and lower faces of the distal extremity of the metatarsal are resected, preserving the joint cartilage that in its centre portion is always healthy. The osteophyte border that may be present in the phalanx is resected. Most frequently, avascular necrosis (AVN) of the talus is a sequel to talar fractures, with the possibility that the AVN increases with the severity of the trauma and the damage associated with the already precarious blood supply of the talus. The surgical treatment used for sesamoid AVN is partial excision of the affected bone. Cite this article: EFORT Open Rev 2020;5:684-690. DOI: 10.1302/2058-5241.5.200007

Effect of Salmon Calcitonin on Cardiac Output, Oxygen Transport and Bone Turnover in Patients with Paget's Disease

1975 ◽  
Vol 48 (6) ◽  
pp. 537-540 ◽  
Author(s):  
W. A. Crosbie ◽  
S. M. Mohamedally ◽  
N. J. Y. Woodhouse
Keyword(s):  
Cardiac Output ◽  
Pain Relief ◽  
Oxygen Transport ◽  
Salmon Calcitonin ◽  
Bone Pain ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Urinary Hydroxyproline ◽  
The Mean ◽  
Hydroxyproline Excretion

1. Twelve patients with symptomatic Paget's disease were studied before starting treatment with salmon calcitonin (12.5 μg) subcutaneously twice daily. Eleven of them were studied again after 3 months on this therapy. 2. Although pretreatment values for urinary total hydroxyproline excretion and cardiac output were considerably increased in some patients, there was no correlation between these two variables in the group as a whole. 3. Treatment resulted in a striking reduction in disease activity; the mean urinary hydroxyproline decreased 67%. 4. There was, however, no significant fall in cardiac output or change in oxygen transport during treatment. 5. Of the eight patients with bone pain who received treatment, five claimed complete pain relief.

scholarly journals Urinary Hydroxyproline Excretion in Male and Female Chickens

1985 ◽  
Vol 64 (6) ◽  
pp. 1216-1218
Author(s):  
INMACULADA DIEZ PRIETO ◽  
FELIPE PRIETO MONTAÑA ◽  
PAULINO GARCIA PARTIDA
Keyword(s):  
Urinary Hydroxyproline ◽  
Male And Female ◽  
Hydroxyproline Excretion
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