TOTAL URINARY HYDROXYPROLINE EXCRETION BEFORE AND AFTER HYPOPHYSECTOMY IN PATIENTS WITH BONE METASTASES FROM BREAST CARCINOMA

1968 ◽  
Vol 59 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Jørn Ditzel ◽  
Robert Jordal ◽  
Niels Riskær
Keyword(s):  
Breast Cancer ◽  
Urinary Excretion ◽  
Bone Metastases ◽  
Healthy Subjects ◽  
Serum Alkaline Phosphatase ◽  
Bone Matrix ◽  
Urinary Hydroxyproline ◽  
Before And After ◽  
The Mean ◽  
Hydroxyproline Excretion

ABSTRACT Recent investigations indicate that the urinary excretion of total hydroxyproline is a measure of the metabolism of collagen, particularly the bone matrix. The total hydroxyproline excretion has been determined in 28 women with bone metastases from breast cancer, and in 12 healthy volunteers. In 22 of the 28 cases with bone metastases the urinary excretion of hydroxyproline was measured shortly before and repeated shortly after hypophysectomy. In addition, the measurements were repeated 3 to 12 months after hypophysectomy in 8 of the patients. The mean excretion of hydroxyproline was significantly higher in patients with bone metastases from breast cancer (52.9 mg/24 h) than in healthy subjects (22.1 mg/24 h). A correlation was found between the urinary excretion of hydroxyproline and serum alkaline phosphatase levels. The mean excretion of total hydroxyproline was 51.0 mg/24 h before hypophysectomy and 63.8 mg/24 h after hypophysectomy. This difference is not statistically significant. Determinations of urinary hydroxyproline excretion in patients with breast cancer has not been found of great value in the assessment of the clinical condition of these patients.

Comparison between CEA, TPA, CA 15/3 and Hydroxyproline, Alkaline Phosphatase, Whole Body Retention of 99mTc MDP in the follow-up of Bone Metastases in Breast Cancer

1990 ◽  
Vol 5 (2) ◽  
pp. 65-72 ◽  
Author(s):  
G. Francini ◽  
M. Montagnani ◽  
R. Petrioli ◽  
P. Paffetti ◽  
S. Marsili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alkaline Phosphatase ◽  
Bone Metastases ◽  
Serum Alkaline Phosphatase ◽  
Whole Body ◽  
Lower Sensitivity ◽  
Osteoblastic Activity ◽  
Body Retention ◽  
Hydroxyproline Excretion

The development of bone metastases in cancer can be monitored easily using three markers: 24 h urinary hydroxyproline excretion (HOP) (an index of osteoclastic activity), serum alkaline phosphatase (Alk.Ph.) (an index of osteoblastic activity) and 24 h whole body retention of 99mTc-methylene diphosphonate (WBR%) (an index of bone turnover). To evaluate the effectiveness of this group of bone tumor markers in breast cancer we compared it with the following group of three markers which are commonly used in the monitoring of breast cancer and in the follow-up of advanced disease with or without bone metastases: carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast carcinoma antigen (CA 15/3). In 48 patients with bone metastases CEA, TPA and CA 15/3 were shown to be sensitive (79%, 85%, 90% respectively), while HOP, Alk.Ph. and WBR%, which are commonly accepted as reliable markers of bone activity, showed a lower sensitivity (67%, 46%, 75% respectively). These results may be explained by the lack of osteoclastic or osteoblastic (or both) activity at the time of diagnosis. This explanation is supported by the fact that the bone markers HOP, Alk.Ph. and WBR% were found to be more sensitive than the others in the subsequent follow-up study. We conclude that in our study, CEA, TPA and CA 15/3 are at first more sensitive than Alk. Ph., HOP and WBR% but during the follow-up Alk.Ph., HOP and WBR% are possibly both more specific and more sensitive

Skeletal Blood Flow in Paget's Disease of Bone and its Response to Calcitonin Therapy

1978 ◽  
Vol 54 (1) ◽  
pp. 69-74 ◽  
Author(s):  
R. Wootton ◽  
J. Reeve ◽  
E. Spellacy ◽  
M. Tellez-Yudilevich
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Flow ◽  
Serum Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Short Term ◽  
Urinary Hydroxyproline ◽  
Rapid Fall ◽  
Hydroxyproline Excretion

1. Blood flow to the skeleton was measured by the 18F clearance method of Wootton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxyproline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.

Hydroxyproline Excretion in the Detection of Occult Bone Metastases from Breast Cancer

Oncology ◽  
1982 ◽  
Vol 39 (5) ◽  
pp. 287-291 ◽  
Author(s):  
A.D. Rowse ◽  
M.J. Morrison ◽  
P.H. Scott ◽  
A.J. Banks ◽  
C. Roginski
Keyword(s):  
Breast Cancer ◽  
Bone Metastases ◽  
Hydroxyproline Excretion

Effect of Salmon Calcitonin on Cardiac Output, Oxygen Transport and Bone Turnover in Patients with Paget's Disease

1975 ◽  
Vol 48 (6) ◽  
pp. 537-540 ◽  
Author(s):  
W. A. Crosbie ◽  
S. M. Mohamedally ◽  
N. J. Y. Woodhouse
Keyword(s):  
Cardiac Output ◽  
Pain Relief ◽  
Oxygen Transport ◽  
Salmon Calcitonin ◽  
Bone Pain ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Urinary Hydroxyproline ◽  
The Mean ◽  
Hydroxyproline Excretion

1. Twelve patients with symptomatic Paget's disease were studied before starting treatment with salmon calcitonin (12.5 μg) subcutaneously twice daily. Eleven of them were studied again after 3 months on this therapy. 2. Although pretreatment values for urinary total hydroxyproline excretion and cardiac output were considerably increased in some patients, there was no correlation between these two variables in the group as a whole. 3. Treatment resulted in a striking reduction in disease activity; the mean urinary hydroxyproline decreased 67%. 4. There was, however, no significant fall in cardiac output or change in oxygen transport during treatment. 5. Of the eight patients with bone pain who received treatment, five claimed complete pain relief.

The Effect of Mental Stress on Catecholamines, their Metabolites and Plasma Renin Activity in Patients with Essential Hypertension and in Healthy Subjects

1979 ◽  
Vol 57 (s5) ◽  
pp. 229s-231s ◽  
Author(s):  
W. Januszewicz ◽  
M. Sznajderman ◽  
B. Wocial ◽  
T. Feltynowski ◽  
T. Klonowicz
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Urinary Excretion ◽  
Mental Stress ◽  
Healthy Subjects ◽  
Plasma Renin ◽  
Renin Activity ◽  
Vanillylmandelic Acid ◽  
Before And After ◽  
Noradrenaline And Adrenaline

1. Ten patients with essential hypertension and ten healthy men were submitted to mental stress consisting of Kraepelin's arithmetic test combined with noise. Concentrations of plasma and urine catecholamines and of their metabolites as well as plasma renin activity before and after the test were studied. 2. In both groups a significant increase of noradrenaline and adrenaline in blood and noradrenaline in urine was observed. The urinary excretion of dopamine fell significantly in both groups after stress. 3. After mental stress a significant increase in urinary excretion of 3-methoxy-4-hydroxyphenylglycol was observed in both groups. The excretion of vanillylmandelic acid decreased significantly only in healthy subjects. 4. The plasma renin activity rose significantly in both groups but the increase was more pronounced in healthy subjects.

Bisphosphonate-induced osteonecrosis of the jaw: Incidence and risk factors in patients with breast cancer and gynecological malignancies

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 1113-1113
Author(s):  
V. Beck ◽  
E. Solomayer ◽  
M. Krimmel ◽  
C. Reinert ◽  
T. Fehm
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Osteonecrosis Of The Jaw ◽  
Bisphosphonate Therapy ◽  
Gynecological Malignancies ◽  
Dental Procedures ◽  
The Mean ◽  
Number Of Treatment

1113 Background: Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption. They are successfully used in conditions of increased bone turnover such as osteoporosis or bone metastases. Since 2003 multiple cases of bisphosphonate-induced osteonecrosis of the jaw (ONJ) were reported. Our purpose was to describe the incidence and risk factors of ONJ in patients with breast cancer or gynecological malignancies. Patients and Methods: ONJ was assessed retrospectively for all patients with breast cancer or gynecological malignancies treated with bisphosphonates at the Department of Gynecology and Obstetrics, University Hospital Tuebingen during April 1999 until May 2006. Results: 10 of 310 (3%) patients with breast cancer or gynecological malignancies developed ONJ while receiving bisphosphonate therapy. All patients with ONJ were treated for bone metastases. Except one all patients with ONJ had a history of recent dental procedures. All patients had received zoledronic acid as part of their bisphosphonate regimen. In 4 of 10 patients this was the only bisphosphonate given. The remaining 6 patients had received at least one of the other bisphosphonates (alendronate, ibandronate, clodronate or pamidronate) before or after zoledronic acid therapy during their course of disease. Time of exposure to bisphosphonates and the number of treatment cycles were significant risk factors for the development of ONJ (p<0.001). In patients diagnosed with ONJ the mean number of treatment cycles was 27 ±18 cycles (median: 21 cycles, range 6–62 cycles) and the mean duration of bisphosphonate therapy was 29 ±20 months (median: 22 months, range 1–67 months). In contrast, the mean number of treatment cycles in patients without manifestation of ONJ was 11 ±12 cycles (median: 6 cycles, range 1–90 cycles). The mean duration of therapy was 12 months (median: 7 months, range 1–81 months). Conclusion: Osteonecrosis of the jaw is regarded a major side effect of bisphosphonate therapy. Length of exposure to bisphosphonates and the number of treatment cycles seem to be the most important risk factors for the development of ONJ. In addition, recent dental procedures favours the development of an ONJ. No significant financial relationships to disclose.

The use of bioimpedance spectroscopy to monitor response to treatment interventions with breast cancer-related lymphedema.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 138-138
Author(s):  
Chirag Shah ◽  
Frank Vicini ◽  
Peter D. Beitsch ◽  
Beth Anglin ◽  
Alison Lisa Laidley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Fluid ◽  
Response To Therapy ◽  
Response To Treatment ◽  
Bioimpedance Spectroscopy ◽  
Post Surgery ◽  
Before And After ◽  
The Mean ◽  
Breast Cancer Related Lymphedema ◽  
Pre Treatment

138 Background: Currently, limited tools are available to assess response to therapy in patients with breast cancer related lymphedema (BCRL). The purpose of this study was to perform an exploratory analysis to determine if, in clinical settings, bioimpedance spectroscopy (BIS) can detect changes in extracellular fluid volume in response to treatment of BCRL. Methods: Three centers that had experience with BIS (L-Dex U400, ImpediMed Limited, Brisbane, Australia) provided retrospective data on 50 patients with breast cancer who were evaluated with BIS at baseline and following loco-regional procedures. Patients had a pre-surgical L-Dex measurement as well as at least 2 post-surgical measurements (before and after BCRL intervention). Decisions regarding intervention were made by physicians with no L-Dex score cut-off utilized. An analysis was performed comparing changes in L-Dex scores for those patients undergoing treatment for BCRL (n=13) versus those not undergoing intervention (n=37). A second analysis was also performed on all patients with elevated L-Dex scores compared to baseline prior to intervention (n=32). Results: The mean age was 54 years old. Fifty four percent of patients underwent SLN biopsy with a mean of 7.9 nodes removed. The mean change in L-Dex score from baseline (pre-treatment) to the first post-surgical L-Dex score measurement was 3.3 +/- 6.8. When comparing the cohort treated for BCRL to those not treated, L-Dex scores were significantly reduced (-4.3 v. 0.1, p=0.005) following intervention. For the subset of patients with elevated L-Dex scores post-surgery, the change in L-Dex score following BCRL intervention was significantly reduced (-5.8 v. 0.1, p=0.001) compared with those observed. Conclusions: These results confirm that BIS can detect increases in L-Dex scores following breast surgery and can also detect reductions in L-Dex scores following intervention for early onset lymphedema. These results demonstrate that BIS has significant clinical utility as it can be used to monitor patients with early BCRL who undergo intervention and to follow these patients (through serial measurements) to document their short and long-term response to these treatments.

PRE- AND POSTOPERATIVE EXCRETION OF TRACE ELEMENTS IN PRIMARY HYPERPARATHYROIDISM

1969 ◽  
Vol 60 (3) ◽  
pp. 380-388 ◽  
Author(s):  
Harry Boström ◽  
Per Olov Wester
Keyword(s):  
Trace Elements ◽  
Neutron Activation Analysis ◽  
Activation Analysis ◽  
Primary Hyperparathyroidism ◽  
Urinary Excretion ◽  
Healthy Subjects ◽  
Biological Significance ◽  
Urinary Levels ◽  
Before And After ◽  
Exchange Technique

ABSTRACT A comparison of the range of urinary excretion of 20 elements (Ag, As, Au, Br, Ce, Cd, Cs, Cu, Fe, Hg, La, Mg, Mo, Rb, Sb, Sc, Se, Sm, W, Zn) in healthy subjects as well as in patients with primary hyperparathyroidism before and after operation was performed by means of a recently developed ion-exchange technique following neutron activation analysis. The urinary levels of the 20 trace elements showed no distinct differences when the controls were compared with the untreated cases of hyperparathyroidism. Small differences in the urinary excretion of certain trace elements in patients with hyperparathyroidism before and after operation were, however, revealed. The biological significance of these findings is discussed.

The Effects of Uni- and Bilateral Fatigue on Postural and Power Tasks

2013 ◽  
Vol 29 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Paulo H. Marchetti ◽  
Maria I.V. Orselli ◽  
Marcos Duarte
Keyword(s):  
Lower Limb ◽  
Healthy Subjects ◽  
Postural Sway ◽  
Center Of Pressure ◽  
Lower Limbs ◽  
Quiet Standing ◽  
Ground Reaction Forces ◽  
Before And After ◽  
Reaction Forces ◽  
The Mean

The aim of this study was to investigate the effects of unilateral and bilateral fatigue on both postural and power bipedal tasks. Ten healthy subjects performed two tasks: bipedal quiet standing and a maximal bipedal counter-movement jumping before and after unilateral (with either the dominant or nondominant lower limb) and bilateral (with both lower limbs) fatigue. We employed two force plates (one under each lower limb) to measure the ground reaction forces and center of pressure produced by subjects during the tasks. To quantify the postural sway during quiet standing, we calculated the resultant center of pressure (COP) speed and COP area of sway, as well as the mean weight distribution between lower limbs. To quantify the performance during the countermovement jumping, we calculated the jump height and the peak force of each lower limb. We observed that both unilateral and bilateral fatigue affected the performance of maximal voluntary jumping and standing tasks and that the effects of unilateral and bilateral fatigue were stronger in the dominant limb than in the nondominant limb during bipedal tasks. We conclude that unilateral neuromuscular fatigue affects both postural and power tasks negatively.

Assessment of Circulating Dickkopf-1 with a New Two-Site Immunoassay in Healthy Subjects and Women with Breast Cancer and Bone Metastases

2009 ◽  
Vol 84 (5) ◽  
pp. 348-354 ◽  
Author(s):  
Nathalie Voorzanger-Rousselot ◽  
Fabrice Journe ◽  
Valérie Doriath ◽  
Jean-Jacques Body ◽  
Patrick Garnero
Keyword(s):  
Breast Cancer ◽  
Bone Metastases ◽  
Healthy Subjects ◽  
Dickkopf 1
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