Blockade of Renin Release by Lanthanum

1974 ◽  
Vol 48 (s2) ◽  
pp. 31s-32s
Author(s):  
A. G. Logan ◽  
I. Tenyi ◽  
T. Quesada ◽  
W. S. Peart ◽  
A. S. Breathnach ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Renin Secretion ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Renal Vasoconstriction ◽  
Perfused Rat Kidney ◽  
Stimulation Of

1. The effects of lanthanum on renin release and renal vasoconstriction were studied in the isolated perfused rat kidney. 2. Lanthanum reduced noradrenaline-induced renal vasoconstriction. 3. Lanthanum prevented isoprenaline-induced and glucagon-induced stimulation of renin secretion.

Stimulation of renin release in perfused kidney by low calcium and high magnesium

1977 ◽  
Vol 232 (4) ◽  
pp. F377-F382 ◽  
Author(s):  
J. S. Fray
Keyword(s):  
Sodium Excretion ◽  
Calcium Concentration ◽  
Perfusion Pressure ◽  
Rat Kidney ◽  
Sodium Concentration ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Low Calcium ◽  
Perfused Rat Kidney ◽  
Stimulation Of

These experiments were designed to test whether changing perfusate calcium or magnesium concentrations affected renin release in the isolated perfused rat kidney, and whether kidneys removed from sodium-loaded or sodium-deprived rats released the same amount of renin in response to identical stimuli. Kidneys were perfused with Kreb-Henseleit solution containing albumin. Renin release was inversely related to perfusate calcium concentration, whereas renin release was directly related to perfusate magnesium. Although a low calcium medium or low perfusion pressure (50 mmHg) stimulated renin release, the release was substantially greater in the sodium-deprived rats. Increasing the perfusate sodium concentration from 85 to 206 mM increased excretion, but did not alter renin release. It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release.

α-Adrenergic Suppression of Renin Secretion in the Rat Independent of Renal Vasoconstriction

1979 ◽  
Vol 57 (s5) ◽  
pp. 161s-163s
Author(s):  
R. Vandongen ◽  
K. D. Strang ◽  
Marianne H. Poesse ◽  
W. H. Birkenhager
Keyword(s):  
Perfusion Pressure ◽  
Rat Kidney ◽  
Renal Perfusion ◽  
Inhibitory Effect ◽  
Renin Secretion ◽  
Renin Release ◽  
Adrenergic Stimulation ◽  
Renal Vasoconstriction ◽  
Adrenergic Mechanism ◽  
Perfused Rat Kidney

1. The effect of α-adrenergic stimulation, with phenylephrine, on isoprenaline-provoked renin secretion was studied in the isolated perfused rat kidney. 2. Infusion of phenylephrine increased renal perfusion pressure and prevented renin secretion in response to isoprenaline. 3. Renal vasoconstriction was abolished and the response in renin secretion to isoprenaline was restored by α-adrenoreceptor blockade with phenoxybenzamine. 4. In contrast, when renal vasoconstriction was prevented by dihydrallazine, suppression of renin release by phenylephrine still occurred. 5. These observations support an inhibitory effect of a non-vascular α-adrenergic mechanism on renin release. It is suggested that the α-receptor mediating this effect is directly related to the renin-producing juxtaglomerular cell.

Nitrendipine-Induced Stimulation of Renin Release by the Isolated Perfused Rat Kidney

1985 ◽  
Vol 180 (1) ◽  
pp. 133-136 ◽  
Author(s):  
R. Loutzenhiser ◽  
M. Epstein ◽  
C. Horton ◽  
R. Hamburger
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Stimulation Of

scholarly journals Adrenergic Stimulation of Renin Secretion in the Isolated Perfused Rat Kidney

1973 ◽  
Vol 32 (2) ◽  
pp. 290-296 ◽  
Author(s):  
ROBERT VANDONGEN ◽  
W. STANLEY PEART ◽  
GRAHAME W. BOYD
Keyword(s):  
Rat Kidney ◽  
Renin Secretion ◽  
Adrenergic Stimulation ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Stimulation Of

The Stimulation of Renin Secretion by Non-Vasocontrictor Infusions of Adrenaline and Noradrenaline in the Isolated Rat Kidney

1975 ◽  
Vol 49 (6) ◽  
pp. 609-612
Author(s):  
R. Vandongen ◽  
Dianne M. Greenwood
Keyword(s):  
Perfusion Pressure ◽  
Rat Kidney ◽  
Renal Perfusion ◽  
Renin Secretion ◽  
Renal Vasoconstriction ◽  
Renal Perfusion Pressure ◽  
Perfused Rat Kidney ◽  
Secretion Rates ◽  
Control Study ◽  
Stimulation Of

1. The effect of adrenaline and noradrenaline on renin secretion in the isolated perfused rat kidney was examined. The doses of catecholamines used were such that renal vasoconstriction and therefore increases in renal perfusion pressure were avoided. Under these conditions adrenaline and noradrenaline significantly increased renin secretion rates, compared with control experiments in which no catecholamine was infused. 2. Mean renal perfusion pressure during both adrenaline and noradrenaline infusion paralleled the control study by showing a progressive fall. 3. Administration of phenoxybenzamine did not impair the stimulation of renin secretion by adrenaline whereas this was prevented by racemic propranolol. 4. These observations suggest that catecholamines stimulate renin secretion by an intrarenal effect which is largely independent of changes in renal perfusion pressure. It is postulated that the beta-adrenoceptors mediating renin secretion are an integral component of the renin-producing cell.

Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney

1990 ◽  
Vol 415 (6) ◽  
pp. 713-717 ◽  
Author(s):  
Rainer Nobiling ◽  
Klaus Münter ◽  
Christian P. Bührle ◽  
Eberhard Hackenthal
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Pulsatile Perfusion

scholarly journals Effects of atrial natriuretic peptide on renal function and renin release in the isolated perfused rat kidney.

1987 ◽  
Vol 28 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Shosaku NARUMI ◽  
Toshiyuki YASUI ◽  
Mamoru YOSHIZAWA ◽  
Minako KAWAMURA ◽  
Hiromichi SUZUKI ◽  
...  
Keyword(s):  
Renal Function ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Atrial Natriuretic

Stimulation of Renin Secretion by Frusemide and Diazoxide in the Isolated Rat Kidney

1976 ◽  
Vol 51 (s3) ◽  
pp. 101s-104s
Author(s):  
R. Vandongen ◽  
Dianne M. Greenwood
Keyword(s):  
Perfusion Pressure ◽  
Rat Kidney ◽  
Renal Perfusion ◽  
Urine Flow ◽  
Renin Secretion ◽  
Stimulatory Action ◽  
Vasodilatory Effect ◽  
Perfused Rat Kidney ◽  
Site Of Action ◽  
Stimulation Of

1. The effect of diazoxide (17·3 μmol min—1 g—1) and frusemide (0·12 μmol min—1 g—1) on renin secretion was examined in the isolated perfused rat kidney. These substances are potential renal vasodilators with opposite effects on urine sodium excretion. 2. Both agents significantly increased renin secretion rate above control values. In the case of frusemide this was not altered by ureteric occlusion and presumed absence of urine flow. 3. Mean renal perfusion pressure decreased to the same extent with diazoxide and frusemide infusion as in the control experiments and no additional vasodilatory effect was observed on the basis of changes in flow rate of perfusate. 4. These observations identify an intrarenal site of action for diazoxide and frusemide on renin secretion. The apparent independence of this stimulatory action on renal vasodilatation and urine flow suggests a direct effect on the renin-producing cell.

scholarly journals Regulation of kallikrein and renin release by the isolated perfused rat kidney

1983 ◽  
Vol 24 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Jiro Misumi ◽  
François Alhenc-Gelas ◽  
Michel Marre ◽  
Jeanine Marchetti ◽  
Pierre Corvol ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney
Sign in / Sign up

Export Citation Format

Share Document