Human Platelet Monoamine Oxidase Activity in Iron-Deficiency Anaemia

1975 ◽  
Vol 48 (4) ◽  
pp. 289-295 ◽  
Author(s):  
B. H. Moussa ◽  
H. F. Woods ◽  
B. Mitchell ◽  
D. G. Grahame-Smith ◽  
Sheila Callender
Keyword(s):  
Iron Deficiency ◽  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Serum Iron ◽  
Iron Deficiency Anaemia ◽  
Iron Concentration ◽  
Monoamine Oxidase Activity ◽  
Deficiency Anaemia ◽  
Normal Limits ◽  
Platelet Monoamine Oxidase

1. The activity of monoamine oxidase, when assayed with four substrates, was significantly lowered in platelets prepared from the blood of patients with iron-deficiency anaemia. 2. Treatment with oral iron preparations restored platelet monoamine oxidase activity to normal in those patients whose serum iron concentrations also returned to normal. 3. Platelet monoamine oxidase activity remained low if treatment failed to restore serum iron concentration to within normal limits.

Some Properties of Human Platelet Monoamine Oxidase in Iron-Deficiency Anaemia

1976 ◽  
Vol 50 (6) ◽  
pp. 479-485 ◽  
Author(s):  
M. B. H. Youdim ◽  
D. G. Grahame-Smith ◽  
H. F. Woods
Keyword(s):  
Iron Deficiency ◽  
Monoamine Oxidase ◽  
Iron Deficiency Anaemia ◽  
Monoamine Oxidase Inhibitor ◽  
Normal Subjects ◽  
Heat Inactivation ◽  
Binding Studies ◽  
Deficiency Anaemia ◽  
Iron Deficient ◽  
Platelet Monoamine Oxidase

1. Monoamine oxidase activity in platelets prepared from the blood of patients with iron-deficiency anaemia was significantly lowered when compared with that in platelets from normal subjects. 2. The Km values of the platelet enzyme for the substrates dopamine, 5-hydroxytryptamine, phenylethylamine and kynuramine were similar for the platelet enzyme from iron-deficient and normal groups. 3. Heat-inactivation studies showed that the platelet monoamine oxidase from iron-deficient subjects was more labile to this treatment, when compared with the platelet enzyme from normal subjects. 4. The sensitivity of platelet monoamine oxidase to the inhibitors, clorgyline and deprenil, was increased in iron-deficiency anaemia. 5. Binding studies with the 14C-binding irreversible monoamine oxidase inhibitor, deprenil, showed that the amount of enzyme capable of binding this inhibitor was lowered by 48% in platelets from iron-deficient patients when compared with platelets from normal subjects. 6. The results show that there is a lowered amount of active enzyme in platelets from iron-deficient subjects. It is suggested that iron is necessary either for the synthesis of monoamine oxidase apoenzyme or is a cofactor for an enzyme which attaches flavin—adenine dinucleotide covalently to the monoamine oxidase apoenzyme.

Platelet monoamine oxidase activity in sensation seekers

1980 ◽  
Vol 3 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Christopher John Fowler ◽  
Lars von Knorring ◽  
Lars Oreland
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Platelet Monoamine Oxidase

Studies of Platelet Monoamine Oxidase Activity during an Acute Cluster Headache Attack.

Cephalalgia ◽  
1991 ◽  
Vol 11 (11_suppl) ◽  
pp. 254-255 ◽  
Author(s):  
Aron D. Mosnaim ◽  
Shankar Huprikar ◽  
Marion E. Wolf ◽  
Frederick Freitag ◽  
Seymour Diamond
Keyword(s):  
Monoamine Oxidase ◽  
Cluster Headache ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Headache Attack ◽  
Cluster Headache Attack ◽  
Platelet Monoamine Oxidase

Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response

1984 ◽  
Vol 11 (3) ◽  
pp. 211-221 ◽  
Author(s):  
Robert J. Hitzemann ◽  
Frederick Sautter ◽  
Barbara Hitzemann ◽  
Jack Hirschowitz ◽  
David L. Garver
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Platelet Monoamine Oxidase ◽  
Lithium Response

PLATELET-MONOAMINE-OXIDASE ACTIVITY PREDICTS RESPONSE TO LITHIUM IN MANIC-DEPRESSIVE ILLNESS

The Lancet ◽  
1977 ◽  
Vol 310 (8052) ◽  
pp. 1325-1327 ◽  
Author(s):  
JohnL. Sullivan ◽  
Allan Maltbie ◽  
JesseO. Cavenar ◽  
Charles Stanfield
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Depressive Illness ◽  
Monoamine Oxidase Activity ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Platelet Monoamine Oxidase

scholarly journals A study to assess the effectiveness of honey dates amla mix on biochemical markers among adolescent girls with Iron deficiency anaemia

2020 ◽  
Vol 11 (2) ◽  
pp. 2288-2293
Author(s):  
Bhuvaneswari G.
Keyword(s):  
Iron Deficiency ◽  
Adolescent Girls ◽  
Biochemical Markers ◽  
Serum Iron ◽  
Iron Deficiency Anaemia ◽  
Control Group ◽  
Deficiency Anaemia ◽  
Post Test ◽  
And Control ◽  
Experimental Group

WHO Global Database on Anaemia for 1993-2005, covering almost half of the world’s population, estimated the prevalence of anaemia worldwide at 25 per cent.The aim of the study is to determine the effectiveness of honey dates amla mix on biochemical markers among adolescent girls with Iron deficiency anaemia. Quantitative experimental and control group pre and post-test design was used in this study. The study was conducted among adolescent girls in two different residential homes. Total study population is 170 adolescent girls were selected by simple random sampling technique. 85 adolescents girls were assigned to the experimental group and 85 participants in control group. For experimental group honey dates amla mix was given for 3 months whereas in  the control group iron and folic acid supplementation were provided. The study results shows that pre and post-test intervention scores of control and experimental group were compared by Wilcoxon scores rank test. Comparison of pre-test and post-test scores of severity of anemia, clinical variables, and level of fatigue and level of satisfaction, bio chemical parameters (reticulocytes, MCV, haematocrite, serum iron, serum ferritin, TIBC) were assessed in both experimental and control group. Between the experimental and control group (unpaired‘t’ test) reticulocytes, mcv, heamatocrite, serum iron serum ferritin showed significant changes in the pre test and post-test but there is no changes in TIBC. The study concluded that alternative nutritional therapy was effective for enhancing the blood heamoglobin & biochemical paramteres level, decreased the clinical variables and fatigue level among the adolescent girls with iron deficiency anemia.

Platelet monoamine oxidase activity is related to MAOB intron 13 genotype

2000 ◽  
Vol 107 (5) ◽  
pp. 523-530 ◽  
Author(s):  
H. Garpenstrand ◽  
J. Ekblom ◽  
K. Forslund ◽  
G. Rylander ◽  
L. Oreland
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Platelet Monoamine Oxidase

PLATELET MONOAMINE OXIDASE ACTIVITY IN TYPE 1 AND TYPE 2 ALCOHOLISM

1991 ◽  
Vol 26 (4) ◽  
pp. 409-416 ◽  
Author(s):  
ANNE-LIIS VON KNORRING ◽  
JARMILA HALLMAN ◽  
LARS VON KNORRING ◽  
LARS ORELAND
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Platelet Monoamine Oxidase
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