The Effect of Ethinyloestradiol on Calcium and Phosphorus Metabolism of Post-Menopausal Women with Primary Hyperparathyroidism

1973 ◽  
Vol 45 (6) ◽  
pp. 785-802 ◽  
Author(s):  
J. C. Gallagher ◽  
R. Wilkinson
Keyword(s):  
Bone Resorption ◽  
Primary Hyperparathyroidism ◽  
Calcium Balance ◽  
Phosphorus Metabolism ◽  
Urine Calcium ◽  
Phosphorus Balance ◽  
Fasting Plasma ◽  
Menopausal Women ◽  
Calcium And Phosphorus ◽  
Post Menopausal

1. Eight post-menopausal women with primary hyperparathyroidism were given ethinyloestradiol (0.05 mg daily) and the effects on calcium and phosphorus metabolism were observed. 2. In every patient ethinyloestradiol produced a fall in fasting plasma and urine calcium. Calcium balance improved in seven patients on treatment and there was a significant fall in 24 h urine calcium in all eight patients; however, there was no consistent change in net or true absorption of calcium. 3. Ethinyloestradiol produced a small fall in the fasting plasma inorganic phosphorus and a fall in fasting urine phosphorus in seven cases. There was a decrease in 24 h urine phosphorus in seven of the eight cases, but there was no consistent effect on phosphorus absorption nor on phosphorus balance. 4. Bone mineralization rate and bone resorption rate were determined in seven of the patients. The administration of ethinyloestradiol produced a decrease in both these variables in all seven patients. 5. The 24 h urine hydroxyproline, used as an independent measure of bone resorption, decreased in all eight patients during ethinyloestradiol therapy. 6. It is concluded that ethinyloestradiol produces an improvement in calcium and phosphorus balance and a decrease in plasma calcium and phosphorus in primary hyperparathyroidism by decreasing bone resorption. 7. It is suggested that ethinyloestradiol may be used as a medical treatment for primary hyperparathyroidism in post-menopausal women who are either unsuitable for surgery or on whom operative procedures have failed, or in those cases in whom primary hyperparathyroidism is mild.

A further study of the effect of sulphanilamide on the metabolism of calcium and phosphorus in the laying hen

1954 ◽  
Vol 45 (2) ◽  
pp. 156-163 ◽  
Author(s):  
C. Tyler
Keyword(s):  
Laying Hens ◽  
Previous Experiment ◽  
Laying Hen ◽  
Calcium Balance ◽  
Phosphorus Metabolism ◽  
Phosphorus Balance ◽  
Calcium Retention ◽  
Calcium And Phosphorus ◽  
Points Of View ◽  
Phosphorus Intake

An experiment has been performed on the effect of sulphanilamide on the calcium and phosphorus metabolism of laying hens.The results showed a decrease in calcium retention and thinner shelled eggs, when sulphanilamide was fed.When the drug was withdrawn the birds took some time to reach normal balance values again, but they immediately produced normally shelled eggs.The results of this experiment, along with a previous experiment, have been considered from other points of view in an attempt to find an explanation of some slightly divergent results. Relationships between calcium retained and calcium in shell and between calcium balance and phosphorus balance have been found and the values for changes in calcium bound to phosphorus and residual calcium in bone have been calculated. These considerations have helped to clear up the discrepancies, and it would appear that sulphanilamide effects may be influenced by season, and by calcium and phosphorus intake.

scholarly journals The severe course of hyperparathyroidism in the elderly: Clinical cases

2009 ◽  
Vol 55 (1) ◽  
pp. 33-35
Author(s):  
N G Mokrysheva ◽  
S S Gulyaeva ◽  
L Ya Rozhinskaya ◽  
V N Smorshchok ◽  
M A Lysenko ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Postmenopausal Women ◽  
Endocrine System ◽  
The Elderly ◽  
Phosphorus Metabolism ◽  
Adequate Treatment ◽  
Calcium And Phosphorus ◽  
Excessive Secretion ◽  
Clinical Cases

Primary hyperparathyroidism (PHPT) is a disease of the endocrine system caused by excessive secretion of parathyroid hormone (PTH) and is characterized by a pronounced violation of calcium and phosphorus metabolism. More recently, in Russia, PHPT was detected extremely rarely and often hid under the mask of recurrent urolithiasis, generalized osteoporosis and other pathologies. As a result, patients did not receive adequate treatment, which in a certain percentage of cases led to the development of serious complications.The clinical cases of severe PHPT in postmenopausal women are presented in this article.

Early effects of ethinyloestradiol and norethisterone treatment in post-menopausal women on bone resorption and calcium regulating hormones

1985 ◽  
Vol 69 (3) ◽  
pp. 265-271 ◽  
Author(s):  
Peter L. Selby ◽  
Munro Peacock ◽  
Stuart A. Barkworth ◽  
Wendy B. Brown ◽  
Geoffrey A. Taylor
Keyword(s):  
Bone Resorption ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Vitamin D Binding Protein ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Menopausal Women ◽  
Early Effects ◽  
Post Menopausal ◽  
Free Plasma

1. The early effects of sex steroid therapy were assessed in 28 normal post-menopausal women, 18 treated with ethinyloestradiol and 10 with norethisterone. 2. There was a reduction in the fasting urinary excretion of both calcium and hydroxyproline with both treatments, indicating reduced bone resorption. This was apparent after 1 week of therapy but became more marked after 3 weeks. 3. These changes were not accompanied by any changes in plasma levels of calcitonin or parathyroid hormone. 4. Patients receiving ethinyloestradiol showed a marked increase in plasma 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentration but this was explicable entirely in terms of increased plasma levels of vitamin D binding protein. There was no change in the free plasma level of 1,25(OH)2D. Patients treated with norethisterone showed no increase in plasma concentrations of 1,25(OH)2D. 5. We conclude that both ethinyloestradiol and norethisterone have a rapid and similar effect in reducing bone resorption. This is not mediated via the plasma levels of the calcium regulating hormones.

scholarly journals Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

2021 ◽  
Vol 22 (17) ◽  
pp. 9136
Author(s):  
Amanda Kornel ◽  
Danja J. Den Hartogh ◽  
Panagiota Klentrou ◽  
Evangelia Tsiani
Keyword(s):  
Bone Resorption ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Current Evidence ◽  
Signaling Proteins ◽  
Bone Homeostasis ◽  
Menopausal Women ◽  
Post Menopausal

Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as seen in osteoporosis or osteopenia. Current treatment strategies aimed to improve bone homeostasis and turnover are lacking in efficacy, resulting in the search for new preventative and nutraceutical treatment options. The myokine irisin, since its discovery in 2012, has been shown to play an important role in many tissues including muscle, adipose, and bone. Evidence indicate that irisin is associated with increased bone formation and decreased bone resorption, leading to reduced risk of osteoporosis in post-menopausal women. In addition, low serum irisin levels have been found in individuals with osteoporosis and osteopenia. Irisin targets key signaling proteins, promoting osteoblastogenesis and reducing osteoclastogenesis. The present review summarizes the existing evidence regarding the effects of irisin on bone homeostasis.

Evidence of increased bone resorption in early post menopausal women with idiopathic hypercalciuria: study with biochemical markers and pQCT of the Tibia

2013 ◽  
Author(s):  
Konstantinos Stathopoulos ◽  
Ilias Bournazos ◽  
Pelagia Katsimbri ◽  
Andonios Partsinevelos ◽  
Aristeides B Zoubos ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Biochemical Markers ◽  
Idiopathic Hypercalciuria ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals The effect of 1-α-hydroxycholecalciferol on calcium and phosphorus metabolism in the lactating ewe

1978 ◽  
Vol 40 (2) ◽  
pp. 387-392 ◽  
Author(s):  
G. D. Braithwaite
Keyword(s):  
Bone Resorption ◽  
Beneficial Effect ◽  
Dairy Cow ◽  
Phosphorus Metabolism ◽  
Mineral Balance ◽  
Milk Fever ◽  
Calcium And Phosphorus ◽  
Parturient Paresis ◽  
P Absorption ◽  
Peak Lactation

1. The effect of 1-α-hydroxycholecalciferol (1 α-OH-D3) on calcium and phosphorus metabolism has been studied in ewes at peak lactation by a combination of a mineral balance and a radioisotope technique.2. The rate of Ca absorption was substantially higher in the treated ewes than in controls. The rates of endogenous loss of Ca into urine, faeces and milk, however, were only slightly higher.3. In consequence, the net retention of Ca was increased and the loss of skeletal reserves of Ca normally associated with peak lactation, prevented.4. Although the rate of bone accretion increased slightly, the increase in skeletal retention of Ca resulted mainly from a decrease in the rate of bone resorption.5. This finding conflicts with the generally held belief that bone resorption is increased by cholecalciferol treatment.6. The rates of apparent absorption and retention of P were increased by the treatment probably as a result of a direct effect of the 1α-OH-D3 on P absorption.7. These results provide a possible explanation of the beneficial effect of 1α-OH-D3 in preventing parturient paresis (milk fever) in the dairy cow.

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