Evidence of increased bone resorption in early post menopausal women with idiopathic hypercalciuria: study with biochemical markers and pQCT of the Tibia

2013 ◽  
Author(s):  
Konstantinos Stathopoulos ◽  
Ilias Bournazos ◽  
Pelagia Katsimbri ◽  
Andonios Partsinevelos ◽  
Aristeides B Zoubos ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Biochemical Markers ◽  
Idiopathic Hypercalciuria ◽  
Menopausal Women ◽  
Post Menopausal

Early effects of ethinyloestradiol and norethisterone treatment in post-menopausal women on bone resorption and calcium regulating hormones

1985 ◽  
Vol 69 (3) ◽  
pp. 265-271 ◽  
Author(s):  
Peter L. Selby ◽  
Munro Peacock ◽  
Stuart A. Barkworth ◽  
Wendy B. Brown ◽  
Geoffrey A. Taylor
Keyword(s):  
Bone Resorption ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Vitamin D Binding Protein ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Menopausal Women ◽  
Early Effects ◽  
Post Menopausal ◽  
Free Plasma

1. The early effects of sex steroid therapy were assessed in 28 normal post-menopausal women, 18 treated with ethinyloestradiol and 10 with norethisterone. 2. There was a reduction in the fasting urinary excretion of both calcium and hydroxyproline with both treatments, indicating reduced bone resorption. This was apparent after 1 week of therapy but became more marked after 3 weeks. 3. These changes were not accompanied by any changes in plasma levels of calcitonin or parathyroid hormone. 4. Patients receiving ethinyloestradiol showed a marked increase in plasma 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentration but this was explicable entirely in terms of increased plasma levels of vitamin D binding protein. There was no change in the free plasma level of 1,25(OH)2D. Patients treated with norethisterone showed no increase in plasma concentrations of 1,25(OH)2D. 5. We conclude that both ethinyloestradiol and norethisterone have a rapid and similar effect in reducing bone resorption. This is not mediated via the plasma levels of the calcium regulating hormones.

scholarly journals Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

2021 ◽  
Vol 22 (17) ◽  
pp. 9136
Author(s):  
Amanda Kornel ◽  
Danja J. Den Hartogh ◽  
Panagiota Klentrou ◽  
Evangelia Tsiani
Keyword(s):  
Bone Resorption ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Current Evidence ◽  
Signaling Proteins ◽  
Bone Homeostasis ◽  
Menopausal Women ◽  
Post Menopausal

Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as seen in osteoporosis or osteopenia. Current treatment strategies aimed to improve bone homeostasis and turnover are lacking in efficacy, resulting in the search for new preventative and nutraceutical treatment options. The myokine irisin, since its discovery in 2012, has been shown to play an important role in many tissues including muscle, adipose, and bone. Evidence indicate that irisin is associated with increased bone formation and decreased bone resorption, leading to reduced risk of osteoporosis in post-menopausal women. In addition, low serum irisin levels have been found in individuals with osteoporosis and osteopenia. Irisin targets key signaling proteins, promoting osteoblastogenesis and reducing osteoclastogenesis. The present review summarizes the existing evidence regarding the effects of irisin on bone homeostasis.

scholarly journals Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Markus Herrmann ◽  
Marius Kraenzlin ◽  
Gerhard Pape ◽  
Marga Sand-Hill ◽  
Wolfgang Herrmann
Keyword(s):  
Bone Mineral Density ◽  
Bone Resorption ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Venous Blood ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Menopausal Women ◽  
Hip Bmd ◽  
Post Menopausal

AbstractBackground: Recently, increased plasma homocysteine (Hcy) has been suggested as an independent risk factor for osteoporotic fractures. Therefore, it is tempting to speculate that Hcy adversely affects bone metabolism. This study aimed to analyze the relation between Hcy and biochemical markers of bone metabolism and bone mineral density (BMD). Materials and methods: We investigated 143 peri- and post-menopausal women [median age (25th–75th percentile), 67 (57–75) years]. All subjects underwent a detailed medical examination, measurement of bone mineral density at lumbar spine (BMD-LS) and total hip (BMD-HIP), and fasting venous blood and urine sampling. Osteocalcin (OC), serum calcium (Ca), urinary desoxypyridinoline cross-links (DPD), osteoprotegerin (OPG) and soluble receptor activator of NF-κB ligand (sRANKL) were studied. Results: According to BMD subjects were classified as normal (n=24), osteopenic (n=51) or osteoporotic (n=68). Median Hcy did not differ between normal, osteopenic and osteoporotic subjects (p=0.647). Partial correlation analysis, controlling for the major confounders, age, creatinine, menopause and previous fractures, revealed significant correlations between Hcy and DPD (r=0.193, p=0.022), as well as between Hcy and Ca (r=0.170, p=0.045). After adjustment for the same confounders, subsequent regression analysis confirmed significant associations of Hcy with DPD and Ca. No significant relations could be observed between Hcy and BMD-LS, BMD-HIP, OC, OPG or sRANKL. Conclusion: Our results demonstrate weak, but significant, relations between Hcy and markers of organic and inorganic bone resorption, suggesting a mechanistic role of Hcy in bone metabolism. The relation between Hcy and bone resorption was not dependent on OPG or sRANKL.

A COMPARATIVE STUDY ON BIOCHEMICAL MARKERS OF BONE COLLAGEN BREAKDOWN IN POST-MENOPAUSAL WOMEN

1997 ◽  
Vol 36 (3) ◽  
pp. 229-235 ◽  
Author(s):  
PAOLO SIRTORI ◽  
CORRADO SOSIO ◽  
RAUL MARCO POLO ◽  
RUGGERO TENNI ◽  
ALESSANDRO RUBINACCI
Keyword(s):  
Comparative Study ◽  
Biochemical Markers ◽  
Bone Collagen ◽  
Menopausal Women ◽  
Post Menopausal
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