The Absorption of the Diastereoisomers of 5-Methyltetrahydropteroylglutamate in Man: A Carrier-Mediated Process

1973 ◽  
Vol 45 (5) ◽  
pp. 625-631 ◽  
Author(s):  
D. G. Weir ◽  
J. P. Brown ◽  
D. S. Freedman ◽  
J. M. Scott
Keyword(s):  
Urinary Excretion ◽  
Coeliac Disease ◽  
Intestinal Absorption ◽  
Intravenous Injection ◽  
Biologically Active ◽  
Human Intestinal Absorption ◽  
Naturally Occurring ◽  
Active Isomer

1. The two diastereoisomers of 5-methyltetrahydropteroylglutamate, the form of folate that predominates in food and bile, were prepared chemically. 2. Their intestinal absorption was compared by means of the urinary-excretion method of 3H-labelled compounds and it was found that the naturally occurring biologically active isomer was excreted to a greater extent. Studies of the clearance of the two forms after intravenous injection showed that this difference was due to preferential intestinal absorption of the naturally occurring isomer. 3. In four patients with coeliac disease, the absorption of the naturally occurring isomer was depressed to the same range as the inactive isomer. 4. Since the two diastereoisomers are chemically inseparable, these results indicate that a carrier-mediated process is involved in the human intestinal absorption of this form of reduced folate.

Synthesis of a biologically active isomer of kotalanol, a naturally occurring glucosidase inhibitor

2010 ◽  
Vol 18 (8) ◽  
pp. 2829-2835 ◽  
Author(s):  
Razieh Eskandari ◽  
Kumarasamy Jayakanthan ◽  
Douglas A. Kuntz ◽  
David R. Rose ◽  
B. Mario Pinto
Keyword(s):  
Biologically Active ◽  
Glucosidase Inhibitor ◽  
Naturally Occurring ◽  
Active Isomer

A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

2018 ◽  
pp. 16-22
Author(s):  
Shukla PK ◽  
Singh MP ◽  
Patel R
Keyword(s):  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Biological Applications ◽  
Plant Origin ◽  
Recent Past ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Biological Aspects ◽  
Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

The Prediction of Human Intestinal Absorption Based on the Molecular Structure

2014 ◽  
Vol 15 (4) ◽  
pp. 380-388 ◽  
Author(s):  
J. Julian-Ortiz ◽  
Riccardo Zanni ◽  
Maria Galvez-Llompart ◽  
Ramon Garcia-Domenech
Keyword(s):  
Molecular Structure ◽  
Intestinal Absorption ◽  
Human Intestinal Absorption

scholarly journals Exploitation of Marine-Derived Robust Biological Molecules to Manage Inflammatory Bowel Disease

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 196
Author(s):  
Muhammad Bilal ◽  
Leonardo Vieira Nunes ◽  
Marco Thúlio Saviatto Duarte ◽  
Luiz Fernando Romanholo Ferreira ◽  
Renato Nery Soriano ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bioactive Compounds ◽  
Bowel Disease ◽  
Clinical Translation ◽  
Biologically Active ◽  
Naturally Occurring ◽  
Inflammatory Bowel ◽  
Functional Features ◽  
Biological Entities ◽  
The Impact

Naturally occurring biological entities with extractable and tunable structural and functional characteristics, along with therapeutic attributes, are of supreme interest for strengthening the twenty-first-century biomedical settings. Irrespective of ongoing technological and clinical advancement, traditional medicinal practices to address and manage inflammatory bowel disease (IBD) are inefficient and the effect of the administered therapeutic cues is limited. The reasonable immune response or invasion should also be circumvented for successful clinical translation of engineered cues as highly efficient and robust bioactive entities. In this context, research is underway worldwide, and researchers have redirected or regained their interests in valorizing the naturally occurring biological entities/resources, for example, algal biome so-called “treasure of untouched or underexploited sources”. Algal biome from the marine environment is an immense source of excellence that has also been demonstrated as a source of bioactive compounds with unique chemical, structural, and functional features. Moreover, the molecular modeling and synthesis of new drugs based on marine-derived therapeutic and biological cues can show greater efficacy and specificity for the therapeutics. Herein, an effort has been made to cover the existing literature gap on the exploitation of naturally occurring biological entities/resources to address and efficiently manage IBD. Following a brief background study, a focus was given to design characteristics, performance evaluation of engineered cues, and point-of-care IBD therapeutics of diverse bioactive compounds from the algal biome. Noteworthy potentialities of marine-derived biologically active compounds have also been spotlighted to underlying the impact role of bio-active elements with the related pathways. The current review is also focused on the applied standpoint and clinical translation of marine-derived bioactive compounds. Furthermore, a detailed overview of clinical applications and future perspectives are also given in this review.

Artificial Simulation of Naturally Occurring, Biologically Active Atmospherics

1994 ◽  
Vol 13 (1) ◽  
pp. 85-92 ◽  
Author(s):  
G. Ruhenstroth-Bauer ◽  
G. Hoffmann ◽  
S. Vogl ◽  
H. Baumer ◽  
R. Kulzer ◽  
...  
Keyword(s):  
Biologically Active ◽  
Naturally Occurring
Sign in / Sign up

Export Citation Format

Share Document