The Effect of Ethanol on the Cough Reflex

1973 ◽  
Vol 45 (4) ◽  
pp. 527-531
Author(s):  
H. Berkowitz ◽  
J. Reichel ◽  
C. Shim
Keyword(s):  
Body Weight ◽  
Citric Acid ◽  
Healthy Subjects ◽  
Pulmonary Infections ◽  
Cough Reflex ◽  
Ethanol Abuse ◽  
Marked Suppression

1. Coughing was induced in ten healthy subjects with various threshold concentrations of nebulized citric acid. The citric acid aerosol method of cough induction proved a reliable and reproducible tool for assessing the cough threshold in an individual. The subjects were retested after consumption of 1 ml of ethanol/kg body weight. Coughing was significantly suppressed in nine of the ten subjects. 2. The marked suppression of the cough reflex by the moderate amounts of ethanol used in this study provides confirmatory evidence for the suspected causal links between ethanol abuse and certain pulmonary infections caused by aspiration.

Coadministration of citric acid allows oxytetracycline dose reduction in yellowtail Seriola quinqueradiata infected with Vibrio anguillarum

2020 ◽  
Vol 140 ◽  
pp. 25-29
Author(s):  
K Akiyama ◽  
N Hirazawa ◽  
A Hatanaka
Keyword(s):  
Body Weight ◽  
Citric Acid ◽  
Effective Treatment ◽  
Dose Reduction ◽  
Vibrio Anguillarum ◽  
Enhancing Effect ◽  
Bacterial Diseases ◽  
Seriola Quinqueradiata ◽  
Poor Efficacy

Oxytetracycline (OTC) has been commonly used as an effective antibiotic against various fish bacterial diseases, including vibriosis. In this study, the absorption-enhancing effect of citric acid on oral OTC pharmacokinetics and treatment of artificial Vibrio anguillarum infection was evaluated in juvenile yellowtail Seriola quinqueradiata followed by serum OTC concentration analysis. When 25 mg kg-1 body weight (BW) OTC was administered in combination with 1250 mg kg-1 BW citric acid, the serum OTC concentration reached almost the same concentration as that of the group treated with 50 mg kg-1 BW OTC. This coadministration successfully suppressed mortality due to vibriosis similar to the group treated with 50 mg kg-1 BW OTC. Conversely, poor efficacy was observed when only 25 mg kg-1 BW OTC was administered. These results suggest that coadministration of citric acid can be beneficial in reducing the dose of OTC needed for effective treatment, and thus contributes to the goal of reduced use of this antibiotic in aquaculture.

scholarly journals Effect of sulindac on the cough reflex of healthy subjects.

1991 ◽  
Vol 31 (2) ◽  
pp. 207-208 ◽  
Author(s):  
G. Foster ◽  
WW Yeo ◽  
LE Ramsay
Keyword(s):  
Healthy Subjects ◽  
Cough Reflex

scholarly journals Utilitas Asam Organik Sari Belimbing Wuluh dan Asam Sitrat Sintetis Sebagai Acidifier Terhadap Performa Produksi Puyuh (Coturnix coturnix Japonica) Fase Grower

2020 ◽  
Vol 7 (2) ◽  
pp. 133
Author(s):  
Hamdan Has ◽  
Astriana Napirah ◽  
Widhi Kurniawan ◽  
La Ode Nafiu ◽  
Takdir Saili
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Citric Acid ◽  
Body Weight Gain ◽  
Coturnix Japonica ◽  
Feed Consumption ◽  
Coturnix Coturnix Japonica ◽  
Feed Conversion ◽  
Coturnix Coturnix ◽  
Randomized Design

ABSTRAKPenggunaan acidifier baik organik atau sintetis dapat meningkatkan optimalisasi nutrien di dalam saluran pencernaan.  Optimalisasi nutrien diharapkan dapat meningkatkan performa ternak khususnya puyuh. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan dua macam acidifier terhadap performa puyuh fase grower. 100 ekor unsexed puyuh (Coturnix coturnix Japonica) fase grower umur 14-40 hari digunakan dalam penelitian yang menggunakan rancangan acak lengkap dengan lima perlakuan dan empat ulangan. Bahan pakan yang digunakan adalah jagung kuning, dedak, konsentrat puyuh komersil, sari belimbing wuluh, dan asam sitrat sintetis. Perlakuan yang dicobakan terdiri dari perlakuan kontrol (P0), penggunaan 0,3% asam sitrat sintetis (P1), penggunaan 0,25% sari belimbing wuluh (P2), penggunaan 0,6% asam sitrat sintetis (P3), dan penggunaan 0,5% sari belimbing wuluh (P4). Variabel yang diamati adalah konsumsi ransum, pertambahan bobot badan dan konversi ransum mingguan. Penggunaan sari belimbing wuluh memiliki konsumsi pakan yang lebih rendah  (P<0,05) pada minggu pertama dibanding kontrol dan asam sitrat sintetis.  Penggunaan asam sitrat sintetis meningkatkan pertambahan bobot badan pada minggu pertama (P<0,05). Penggunaan asam sitrat sintetis nyata dapat menurunkan konversi pakan minggu ke tiga dan empat dibanding kontrol dan asam organik belimbing wuluh. Kesimpulan penelitian ini yaitu penggunaan sari belimbing wuluh sebagai acidifier belum menunjukkan perbaikan performa yang signifikan sedangkan penggunaan asam sitrat sintetis memiliki performa yang lebih baik dibanding perlakuan kontrol dan penggunaan sari belimbing wuluh.Kata kunci: acidifier, asam sitrat, belimbing wuluh, puyuh fase growerABSTRACTThe organic and synthetic acidifiers could improve the optimization of nutrients utilization in the quail digestive tract. Furthermore, the optimization of nutrients is expected to improve quail performance. This study was aimed to determine the effect of using two types of acidifiers (Averrhoa bilimbi juice and synthetic citric acid) on the grower phase of quail performance. Total of 100 unsexed quails (Coturnix coturnix japonica) grower phase aged 14-40 days were used in this research and designed as a completely randomized design of five treatments and four replications. Feed ingredients used were yellow corn, rice bran, commercial quail concentrate, Averrhoa bilimbi juice (organic acidifier), and synthetic citric acid. The treatments consisted of control (P0), 0.3% synthetic citric acid (P1), use of 0.25% Averrhoa bilimbi juice (P2), use of 0.6% synthetic citric acid (P3), and use of 0.5% Averrhoa bilimbi juice (P4). The variables observed were weekly feed intake, body weight gain, and feed conversion. The result showed that utilization of Averrhoa bilimbi juice has lower feed consumption (P<0.05) in the first week compare to control and synthetic citric acid, and synthetic citric acid utilization increases body weight gain in the first week (P<0.05). The use of synthetic citric acid significantly reduces feed conversion in the third and fourth weeks compared to control and organic acid groups. The conclusion of this study is the utilization of Averrhoa bilimbi juice as an acidifier has not shown significant improvements in quail performance. The use of synthetic citric acid has a better performance compared to control and Averrhoa bilimbi juice utilization.Keywords: acidifier, organic acidifier, citric acid, growing quail

scholarly journals Prostaglandin E2 sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 channels

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Al-Shaimaa A. Al-Kandery ◽  
Muddanna S. Rao ◽  
Ahmed Z. El-Hashim
Keyword(s):  
Citric Acid ◽  
Nucleus Tractus Solitarius ◽  
Whole Body ◽  
Prostaglandin E ◽  
Cough Reflex ◽  
Trpv1 Antagonist ◽  
Underlying Mechanisms ◽  
Set Up ◽  
Guinea Pig Model ◽  
Ep3 Receptor

Abstract Background Cough hypersensitivity is a major characteristic feature associated with several types of cough, including chronic cough, but its underlying mechanisms remain to be fully understood. Inflammatory mediators, such as prostaglandin E2 (PGE2), have been implicated in both peripheral induction and sensitization of the cough reflex. In this study, using a conscious guinea pig model of cough, we investigated whether PGE2 can sensitize the cough reflex via central actions and, if so, via which mechanisms. Methods All drugs were administered by intracerebroventricular (i.c.v.) route and whole-body plethysmograph set-up was used for both induction, using aerosolized citric acid (0.2 M), and recording of cough. Immunohistochemistry was performed to confirm the expression of NaV 1.8 channels in the nucleus tractus solitarius (nTS). Results We show that both PGE2 and the non-selective EP1/EP3 agonist, sulprostone, dose-dependently enhanced the citric acid-induced cough (P ≤ 0.001, P ≤ 0.01, respectively). Pretreatment with the EP1 antagonist, ONO-8130, did not affect the sulprostone-induced cough sensitization, whilst the EP3 antagonist, L-798,106, dose-dependently inhibited this effect (P ≤ 0.05). Furthermore, treatment with either the EP2 agonist, butaprost or the EP4 agonist, L-902,688, had no effect on cough sensitization. Additionally, pretreatment with either the TRPV1 antagonist, JNJ-17203212 or the TRPA1 antagonist, HC-030031, alone or in combination, nor with the NaV 1.1, 1.2, 1.3, 1.4, 1.6 and 1.7 channel blocker, tetrodotoxin, had any effect on the cough. In contrast, pretreatment with the NaV 1.8 antagonist, A-803467, dose-dependently inhibited this effect (P ≤ 0.05). Furthermore, NaV 1.8 channels were shown to be expressed in the nTS. Conclusion Collectively, our findings show that PGE2 sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 but independently of TRPV1,TRPA1 and TTX-sensitive sodium channel activation. These results indicate that PGE2 plays an important role in central sensitization of the cough reflex and suggest that central EP3 receptors and/or NaVv 1.8 channels may represent novel antitussive molecular targets. Graphical Abstract

scholarly journals Profil Plumbum (Pb) dan Cadmium (Cd) sebagai Kontaminan Dampak Penggunaan Agrokimia serta Remediasi Biji Kedelai Menggunakan Swelling Agent pada Khelasi dengan Asam Sitrat

2014 ◽  
Vol 15 (1) ◽  
pp. 45
Author(s):  
Sapto Priyadi ◽  
Purnama Darmaji ◽  
Umar Santoso ◽  
Pudji Hastuti
Keyword(s):  
Body Weight ◽  
Citric Acid ◽  
Concentration Factor ◽  
Daily Intake ◽  
Soybean Seeds ◽  
Acceptable Daily Intake ◽  
Cultivation System ◽  
Swelling Agent ◽  
High Level ◽  
The Impact

This research were aimed to know the plumbum (Pb) and cadmium (Cd) profile on soybean seeds as contaminants of the impact use of agrochemistry material impact and to know of swelling agent of N,N-dimethylformamide (DMF) needs at certain level of pH in chelation with citric acid. The results showed that the content of Pb in soybean seeds at cultivation system agrochemistry materials i.e. 0.63 ppm, while cultivation system without agrochemistry materials i.e. 0.46 ppm. Cd content in soybean seeds at cultivation system agrochemistry materials i.e. 0.05 ppm and the cultivation system without agrochemistry materials i.e. 0.1 ppm. Acceptable daily intake in terms of Pb content in soybean after treatment increases to 2.93 times compared before treatment (11.3379 to 33.2099 g per body weight per day). Acceptable daily intake in terms of the content of the Cd in soybean after treatment increases to 5.26 times compared before treatment. The value of the bio-concentration factor which expressed an accumulation of Pb in soybean seeds on both cultivation is low system (BCF<250), while for Cd is a moderate to high level (1.000<BCF>250). Cd reduction on soybeans seeds for all chelation treatment was maximum (not detected-detection limits was 0.01 ppm), while the highest reduction of Pb occurs at swelling agent N, N-dimethylformamide 15 mL at pH 10.

scholarly journals Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs

2018 ◽  
Vol 314 (3) ◽  
pp. R489-R498 ◽  
Author(s):  
Yang-Ling Chou ◽  
Nanako Mori ◽  
Brendan J. Canning
Keyword(s):  
Citric Acid ◽  
Guinea Pigs ◽  
Respiratory Pattern ◽  
Tracheal Mucosa ◽  
Cough Reflex ◽  
C Fibers ◽  
Selective Agonist ◽  
Nodose Ganglia ◽  
C Fiber ◽  
Opposing Effects

We have addressed the hypothesis that the opposing effects of bronchopulmonary C-fiber activation on cough are attributable to the activation of C-fiber subtypes. Coughing was evoked in anesthetized guinea pigs by citric acid (0.001–2 M) applied topically in 100-µl aliquots to the tracheal mucosa. In control preparations, citric acid evoked 10 ± 1 coughs cumulatively. Selective activation of the pulmonary C fibers arising from the nodose ganglia with either aerosols or continuous intravenous infusion of adenosine or the 5-HT3 receptor-selective agonist 2-methyl-5-HT nearly abolished coughing evoked subsequently by topical citric acid challenge. Delivering adenosine or 2-methyl-5-HT directly to the tracheal mucosa (where few if any nodose C fibers terminate) was without effect on citric acid-evoked cough. These actions of pulmonary administration of adenosine and 2-methyl-5-HT were accompanied by an increase in respiratory rate, but it is unlikely that the change in respiratory pattern caused the decrease in coughing, as the rapidly adapting receptor stimulant histamine also produced a marked tachypnea but was without effect on cough. In awake guinea pigs, adenosine failed to evoke coughing but reduced coughing induced by the nonselective C-fiber stimulant capsaicin. We conclude that bronchopulmonary C-fiber subtypes in guinea pigs have opposing effects on cough, with airway C fibers arising from the jugular ganglia initiating and/or sensitizing the cough reflex and the intrapulmonary C fibers arising from the nodose ganglia actively inhibiting cough upon activation.

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