The Intestinal Absorption of Phosphorus. Its Relation to Calcium Absorption and to Treatment with Vitamin D in Osteomalacia, Parathyroid Dysfunction and Chronic Renal Failure

1972 ◽  
Vol 42 (4) ◽  
pp. 16P-16P ◽  
Author(s):  
T. C. B. Stamp
1974 ◽  
Vol 52 (2) ◽  
pp. 272-274 ◽  
Author(s):  
R. Gagnon ◽  
G. W. Ogden ◽  
G. Just ◽  
M. Kaye

The effect of dihydrotachysterol2 and of 5,6-trans vitamin D3 on calcium absorption in patients with severe chronic renal failure were compared. Dihydrotachysterol appeared to be more effective than the vitamin D analogue.


1977 ◽  
Vol 52 (5) ◽  
pp. 499-508 ◽  
Author(s):  
J. B. Eastwood ◽  
T. C. B. Stamp ◽  
H. E. De Wardener ◽  
P. J. Bordier ◽  
C. D. Arnaud

1. Five patients with the osteomalacia of chronic renal failure were given 50–100 nmol of 25-hydroxy vitamin D3 intravenously per day for 24–28 days. 2. In all five patients, during administration of 25-hydroxy vitamin D3 there was a substantial rise in the plasma concentration of 25-hydroxy vitamin D from initially abnormally low values. 3. Significant improvement in bone mineralization, intestinal calcium absorption and muscle strength occurred in the three patients with the greatest rise in plasma 25-hydroxy vitamin D.


2015 ◽  
Vol 21 (3) ◽  
pp. 887-890 ◽  
Author(s):  
Bistra T. Galunska ◽  
◽  
Daniela I. Gerova ◽  
Dobrin N. Paskalev ◽  
Rositza Y. Zorcheva ◽  
...  

1994 ◽  
Vol 87 (3) ◽  
pp. 363-368 ◽  
Author(s):  
Aubrey Blumsohn ◽  
Brian Morris ◽  
Richard Eastell

1. Stable strontium (Sr) has been proposed as an alternative to calcium (Ca) isotopes for the measurement of intestinal Ca absorption. The aim of this study was to compare the time course and fractional absorption of Ca and Sr, when both are measured using dual-tracer techniques. 2. 45Ca and Sr absorption tests were carried out on consecutive days in patients with osteoporosis (n = 10) or chronic renal failure (n = 7). Both tests were repeated in four patients with chronic renal failure after treatment with calcitriol (1 μg daily for 10 days). 3. The time course of Ca absorption was determined using the 85Sr (intravenous)/45Ca (oral) dual-tracer technique, and the time course of Sr absorption using 85Sr (intravenous)/stable Sr (oral). Oral tracers were administered on consecutive days with a test meal containing 5.3 mmol of Ca and 2.5 mmol of either stable Sr or Ca carrier. The fractional absorption of 45Ca and Sr at 6 h (FA360) and the absorption rate as a function of time were calculated by deconvolution. 4. The mean FA360 for Sr (20.2%) was lower than the mean FA360 for 45Ca (37.8%, P < 0.001, paired t-test), but the time course of Sr absorption was similar to that of Ca. There was a significant correlation between the FA360 for 45Ca and Sr, although the relationship was improved by including a quadratic term (R2 = 0.89, P < 0.001, significance of quadratic term, P < 0.05). After 1,25-dihydroxyvitamin D treatment, the FA360 of stable Sr increased 4.29-fold, whereas the FA360 of 45Ca increased only 2.4-fold. 5. Although the fractional absorption of Sr determined by dual-tracer deconvolution was the best predictor of FA360 for 45Ca, little was lost by confining the analysis to a single serum Sr measurement taken 3 h or more after oral administration. 6. We conclude that Sr absorption is qualitatively similar to that of Ca, although absorption of Sr is much lower than that of Ca. Furthermore, the relationship does not appear to be linear. Stable Sr may be useful in place of Ca isotopes in the routine clinical evaluation of Ca absorption.


1997 ◽  
Vol 7 (S3) ◽  
pp. 202-208 ◽  
Author(s):  
E. Slatopolsky ◽  
A. J. Brown

The Lancet ◽  
1975 ◽  
Vol 305 (7916) ◽  
pp. 1147
Author(s):  
C.E. Dent ◽  
Mercedes Domenech ◽  
J.M. Gertner

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