The role of blood cells and their microparticles in blood coagulation

2005 ◽  
Vol 33 (2) ◽  
pp. 418-422 ◽  
Author(s):  
K.-E. Eilertsen ◽  
B. Østerud
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Blood Cells ◽  
Essential Role ◽  
Transmembrane Glycoprotein

The transmembrane glycoprotein TF (tissue factor) plays an essential role in haemostasis as the principal initiator of blood coagulation. In this paper, we describe how the circulating blood cells – monocytes, platelets, neutrophils and their microparticles – co-operate in regulating the expression, availability and activity of monocyte-derived TF.

The Tissue Factor Pathway and Wound Healing

2017 ◽  
Vol 44 (02) ◽  
pp. 142-150 ◽  
Author(s):  
Maureane Hoffman
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Cell Signaling ◽  
Tissue Factor ◽  
Blood Coagulation ◽  
Host Response ◽  
Cellular Processes ◽  
Injured Tissue ◽  
Tissue Factor Pathway

AbstractThe role of tissue factor (TF) as the major initiator of hemostatic blood coagulation is well recognized. The ability to form an adequate hemostatic clot is essential to the normal healing of an injury by staunching bleeding, stabilizing the injured tissue, and serving as a scaffold for repair processes. Also, some molecules produced during hemostasis, particularly thrombin, have cytokine and growth factor-like activities that contribute to inflammation and repair. However, TF itself has activities as a regulator of cellular processes via direct signaling, as well as by facilitating activation of proteolytically activated receptors by activated factors VII and X. The importance of hemostasis in the host response to injury makes it very difficult to separate the hemostatic from nonhemostatic effects of TF on wound healing. The literature in this area remains sparse but suggests that TF influences the course and tempo of healing by cell signaling events that impact inflammation, epithelialization, and angiogenesis.

Role of Tissue Factor-FVIIa Blood Coagulation Initiation Complex in Cancer

2017 ◽  
pp. 101-119 ◽  
Author(s):  
Abhishek Roy ◽  
Ramesh Prasad ◽  
Anindita Bhattacharya ◽  
Kaushik Das ◽  
Prosenjit Sen
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Initiation Complex

Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis

2019 ◽  
Vol 45 (04) ◽  
pp. 396-412 ◽  
Author(s):  
Araci M. R. Rondon ◽  
Chantal Kroone ◽  
Maaike Y. Kapteijn ◽  
Henri H. Versteeg ◽  
Jeroen T. Buijs
Keyword(s):  
Tissue Factor ◽  
Cancer Progression ◽  
Coagulation Cascade ◽  
Clinical Phase ◽  
Transmembrane Glycoprotein ◽  
Cancer Models ◽  
Cytotoxic Compounds ◽  
Cancer Associated Thrombosis ◽  
Tumor Types

AbstractIt has been long-established that cancer and thrombosis are linked, but the exact underlying pathological mechanism remains to be unraveled. As the initiator of the coagulation cascade, the transmembrane glycoprotein tissue factor (TF) has been intensely investigated for its role in cancer-associated thrombosis and cancer progression. TF expression is regulated by both specific oncogenes and environmental factors, and it is shown to regulate primary growth and metastasis formation in a variety of cancer models. In clinical studies, TF has been shown to be overexpressed in most cancer types and is strongly associated with disease progression. While TF clearly associates with cancer progression, a prominent role for TF in the development of cancer-associated thrombosis is less clear. The current concept is that cancer-associated thrombosis is associated with the secretion of tumor-derived TF-positive extracellular vesicles in certain tumor types. To date, many therapeutic strategies to target TF—both in preclinical and clinical phase—are being pursued, including targeting TF or the TF:FVIIa complex by itself or by exploiting TF as a docking molecule to deliver cytotoxic compounds to the tumor. In this review, the authors summarize the current understanding of the role of TF in both cancer progression and cancer-associated thrombosis, and discuss novel insights on TF as a therapeutic target as well as a biomarker for cancer progression and VTE.

scholarly journals Tissue factor, protease activated receptors and pathologic heart remodelling

2014 ◽  
Vol 112 (11) ◽  
pp. 893-900 ◽  
Author(s):  
Silvio Antoniak ◽  
Erica Sparkenbaugh ◽  
Rafal Pawlinski
Keyword(s):  
Myocardial Infarction ◽  
Tissue Factor ◽  
Essential Role ◽  
Viral Myocarditis ◽  
Cellular Responses ◽  
Coagulation Cascade ◽  
Tissue Factor Expression ◽  
Protease Activated Receptors ◽  
Factor Expression

SummaryTissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.

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