Evidence for an Essential Role of Tissue Factor Dependent Blood Coagulation in the Pathogenesis of the Local Shwartzman Reaction

1995 ◽  
Vol 21 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Ariella Zivelin ◽  
L.Vijaya Mohan Rao ◽  
Samuel I. Rapaport
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Essential Role ◽  
Shwartzman Reaction ◽  
Local Shwartzman Reaction

The role of blood cells and their microparticles in blood coagulation

2005 ◽  
Vol 33 (2) ◽  
pp. 418-422 ◽  
Author(s):  
K.-E. Eilertsen ◽  
B. Østerud
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Blood Cells ◽  
Essential Role ◽  
Transmembrane Glycoprotein

The transmembrane glycoprotein TF (tissue factor) plays an essential role in haemostasis as the principal initiator of blood coagulation. In this paper, we describe how the circulating blood cells – monocytes, platelets, neutrophils and their microparticles – co-operate in regulating the expression, availability and activity of monocyte-derived TF.

The Tissue Factor Pathway and Wound Healing

2017 ◽  
Vol 44 (02) ◽  
pp. 142-150 ◽  
Author(s):  
Maureane Hoffman
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Cell Signaling ◽  
Tissue Factor ◽  
Blood Coagulation ◽  
Host Response ◽  
Cellular Processes ◽  
Injured Tissue ◽  
Tissue Factor Pathway

AbstractThe role of tissue factor (TF) as the major initiator of hemostatic blood coagulation is well recognized. The ability to form an adequate hemostatic clot is essential to the normal healing of an injury by staunching bleeding, stabilizing the injured tissue, and serving as a scaffold for repair processes. Also, some molecules produced during hemostasis, particularly thrombin, have cytokine and growth factor-like activities that contribute to inflammation and repair. However, TF itself has activities as a regulator of cellular processes via direct signaling, as well as by facilitating activation of proteolytically activated receptors by activated factors VII and X. The importance of hemostasis in the host response to injury makes it very difficult to separate the hemostatic from nonhemostatic effects of TF on wound healing. The literature in this area remains sparse but suggests that TF influences the course and tempo of healing by cell signaling events that impact inflammation, epithelialization, and angiogenesis.

Role of Tissue Factor-FVIIa Blood Coagulation Initiation Complex in Cancer

2017 ◽  
pp. 101-119 ◽  
Author(s):  
Abhishek Roy ◽  
Ramesh Prasad ◽  
Anindita Bhattacharya ◽  
Kaushik Das ◽  
Prosenjit Sen
Keyword(s):  
Tissue Factor ◽  
Blood Coagulation ◽  
Initiation Complex

scholarly journals THE ROLE OF VASOCONSTRICTION IN THE LOCAL SHWARTZMAN REACTION

1957 ◽  
Vol 105 (6) ◽  
pp. 643-652 ◽  
Author(s):  
David P. Rall ◽  
Margaret G. Kelly
Keyword(s):  
Nitrogen Mustard ◽  
Lactic Acid Production ◽  
Metabolic Changes ◽  
Bacterial Polysaccharide ◽  
Specific Sequence ◽  
Abdominal Skin ◽  
Shwartzman Reaction ◽  
Adrenergic Blocking ◽  
Local Shwartzman Reaction

The local Shwartzman reaction was provoked in the skin of the ear, hind leg, and costovertebral angle of the rabbit, as well as in the ventral abdominal skin. Certain adrenergic blocking drugs reduced the incidence of positive reactions when given prior to the provocative dose of bacterial polysaccharide. Epinephrine and other vasoconstrictor drugs administered intradermally into the prepared skin site produced typical hemorrhagic-necrotic lesions when the usual intravenous injection of polysaccharide was omitted. This reaction could be blocked by adrenergic blocking drugs, but appeared to be augmented by heparin or nitrogen mustard. A hypothesis has been developed to help explain the mechanism of the local Shwartzman reaction. Following the preparatory dose, tissue metabolic changes occur which lead to increased lactic acid production and render the area particularly susceptible to anoxia. Following the provocative dose, adrenergic vasoconstriction occurs. It is suggested that this vasoconstriction may be intensified at the prepared site by small residual amounts of the preparatory dose of polysaccharide which might potentiate the action of the epinephrine. The anoxia initiated by the vasoconstriction is prolonged and intensified by the formation of intravascular thrombi around clumps of leucocytes and platelets. This anoxia, superimposed on the local metabolic changes, leads to the characteristic lesion of hemorrhage and necrosis. Thus a combination of factors, all of causal importance and largely due to known pharmacologic properties of bacterial lipopolysaccharide, occur in specific sequence to lead to the classic local Shwartzman reaction.

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