Novel peptoids for the detection and suppression of reactive oxygen and nitrogen species

2003 ◽  
Vol 31 (6) ◽  
pp. 1302-1304 ◽  
Author(s):  
A.E.O. Fisher ◽  
D.P. Naughton
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Reaction Products ◽  
Cupric Ion ◽  
Redox Active ◽  
Active Metal ◽  
Metal Ion Activation ◽  
Redox Active Metal

Novel peptoids useful for the detection and suppression of various components contributing to oxidative stress and for elucidation of the interplay between these species are presented. Oxidative stress involves redox-active metal ion activation/generation of RONS (reactive oxygen and nitrogen species). For detection of RONS, the peptoid probes consist of a conjugate designed to (1) complex redox-active and non-redox-active metal ions, and (2) differentiate between RONS based upon the reaction products following RONS attack on the probe. For suppression of RONS, subtle modifications in peptoid structure impart catalase and superoxide dismutase activities to the peptoids upon ferric or cupric ion complexation.

Redox active metal-induced oxidative stress in biological systems

2012 ◽  
Vol 37 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Klaudia Jomova ◽  
Stanislav Baros ◽  
Marian Valko
Keyword(s):  
Oxidative Stress ◽  
Biological Systems ◽  
Redox Active ◽  
Active Metal ◽  
Redox Active Metal

scholarly journals Hypothesis: Soluble AβOligomers in Association with Redox-Active Metal Ions Are the Optimal Generators of Reactive Oxygen Species in Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Brian J. Tabner ◽  
Jennifer Mayes ◽  
David Allsop
Keyword(s):  
Alzheimer’S Disease ◽  
Reactive Oxygen Species ◽  
Alzheimer's Disease ◽  
Hydrogen Peroxide ◽  
Metal Ions ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Redox Active ◽  
Active Metal ◽  
Redox Active Metal

Considerable evidence points to oxidative stress in the brain as an important event in the early stages of Alzheimer's disease (AD). The transition metal ions of Cu, Fe, and Zn are all enriched in the amyloid cores of senile plaques in AD. Those of Cu and Fe are redox active and bind to Aβin vitro. When bound, they can facilitate the reduction of oxygen to hydrogen peroxide, and of the latter to the hydroxyl radical. This radical is very aggressive and can cause considerable oxidative damage. Recent research favours the involvement of small, soluble oligomers as the aggregating species responsible for Aβ neurotoxicity. We propose that the generation of reactive oxygen species (i.e., hydrogen peroxide and hydroxyl radicals) by these oligomers, in association with redox-active metal ions, is a key molecular mechanism underlying the pathogenesis of AD and some other neurodegenerative disorders.

scholarly journals Antioxidants of Natural Products

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 612
Author(s):  
Mee Ree Kim
Keyword(s):  
Oxidative Stress ◽  
Health Promotion ◽  
Natural Products ◽  
Disease Prevention ◽  
Biological Systems ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Beneficial Effects

Antioxidant ingredients are known to contribute to the beneficial effects of natural products in health promotion as well as disease prevention by reducing oxidative stress, caused by reactive oxygen or nitrogen species, in biological systems [...]

The emerging molecular structure of the nitrogen cycle: an introduction to the proceedings of the 10th annual N-cycle meeting

2005 ◽  
Vol 33 (1) ◽  
pp. 113-118 ◽  
Author(s):  
C.S. Butler ◽  
D.J. Richardson
Keyword(s):  
Structural Biology ◽  
Nitrogen Cycle ◽  
Reaction Mechanisms ◽  
Spectroscopic Analysis ◽  
Three Dimensional ◽  
Chemical Transformations ◽  
Redox Active ◽  
Active Metal ◽  
Insight Into ◽  
Redox Active Metal

Over the last 10 years, during the lifetime of the nitrogen cycle meetings, structural biology, coupled with spectroscopy, has had a major impact of our understanding enzymology of the nitrogen cycle. The three-dimensional structures for many of the key enzymes have now been resolved and have provided a wealth of information regarding the architecture of redox active metal sites, as well as revealing novel structural folds. Coupled with structure-based spectroscopic analysis, this has led to new insight into the reaction mechanisms of the diverse chemical transformations that together cycle nitrogen in the biosphere. An overview of the some of the key developments in field over the last decade is presented.

scholarly journals Confining the spin between two metal atoms within the carbon cage: redox-active metal–metal bonds in dimetallofullerenes and their stable cation radicals

Nanoscale ◽  
2017 ◽  
Vol 9 (23) ◽  
pp. 7977-7990 ◽  
Author(s):  
Nataliya A. Samoylova ◽  
Stanislav M. Avdoshenko ◽  
Denis S. Krylov ◽  
Hannah R. Thompson ◽  
Amelia C. Kirkhorn ◽  
...  
Keyword(s):  
Carbon Cage ◽  
Cation Radicals ◽  
Metal Atoms ◽  
Redox Active ◽  
Active Metal ◽  
Metal Metal ◽  
Metal Metal Bonds ◽  
Metal Bonds ◽  
Redox Active Metal

Dioxygen-derived radicals in biological systems

1985 ◽  
Vol 311 (1152) ◽  
pp. 605-615 ◽  
Keyword(s):  
Respiratory Burst ◽  
Electrochemical Method ◽  
Culture Medium ◽  
Biological Systems ◽  
Cellular Systems ◽  
Superoxide Ion ◽  
Radical Species ◽  
Redox Active ◽  
Active Metal ◽  
Redox Active Metal

Three instances of the involvement of dioxygen-derived radicals in biological systems are considered. The first concerns the formation of radicals in the haemolytic reactions induced by treatment of erythrocytes by phenylhydrazine, as an example of the so-called ‘oxidant drugs’. The evidence for the formation of phenyl radicals is considered and their origin in the oxidation of phenylhydrazine by a ferryl derivative of haemoglobin postulated. The relevance to the formation of phenylated iron and porphyrin species is described. It is suspected that many instances of oxidative damage to cellular systems result from the coincidence of unsequestered redox-active metal ions (particularly those of iron and copper), reductants, and dioxygen. As an example, the damage to hepatocytes, grown in a culture medium containing cysteine, is described. The formation of radical species derived from dioxygen during the respiratory burst associated with phagocytosis is discussed. A new electrochemical method of detecting the superoxide ion produced during the respiratory burst is described. Particular emphasis is placed on the relation between the production of radical species such as the hydroxyl radical and the superoxide ion, and the extent of phagocytosis.

scholarly journals Negative cooperativity upon hydrogen bond-stabilized O2 adsorption in a redox-active metal–organic framework

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Julia Oktawiec ◽  
Henry Z. H. Jiang ◽  
Jenny G. Vitillo ◽  
Douglas A. Reed ◽  
Lucy E. Darago ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Metal Organic Framework ◽  
Negative Cooperativity ◽  
O2 Adsorption ◽  
Redox Active ◽  
Active Metal ◽  
Metal Organic ◽  
Redox Active Metal ◽  
Organic Framework
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