Mechanism of action of interferon on oestrogen receptor function

1996 ◽  
Vol 24 (3) ◽  
pp. 366S-366S ◽  
Author(s):  
A.P.F. Flint ◽  
D.R.E. Abayasekara ◽  
P.R. Riley ◽  
E.L. Sheldrick ◽  
A.M. Clarkson
Keyword(s):  
Mechanism Of Action ◽  
Oestrogen Receptor ◽  
Receptor Function

Changes in a proposed new neuroendocrine marker of oestrogen receptor function in postpartum women

1990 ◽  
Vol 20 (4) ◽  
pp. 779-783 ◽  
Author(s):  
J. A. Bearn ◽  
K. M. Fairhall ◽  
I. C. A. F. Robinson ◽  
S. L. Lightman ◽  
S. A. Checkley
Keyword(s):  
Oestrogen Receptor ◽  
Time Course ◽  
Postpartum Women ◽  
Oestrogen Receptors ◽  
Receptor Function ◽  
Puerperal Psychosis ◽  
Neuroendocrine Marker ◽  
Central Response ◽  
Normal Women ◽  
Dose Dependent

SynopsisWe describe a novel neuroendocrine test which reflects a central response to activation of oestrogen receptors. This is achieved by measurement of plasma levels of oestrogen-stimulated neurophysin (ESN) following an oestrogen challenge. In normal women the ESN response to ethinyl oestradiol is dose-dependent. This response is attenuated in normal women during the first postpartum month, although it is unchanged in patients with anorexia nervosa, in spite of their similar concurrent hypo-estrogenic state. The altered puerperal response may result from the acute oestrogen withdrawal which occurs at delivery. The time course of the altered ESN response coincides with the period of maximum risk for puerperal psychosis. The ESN response to oestrogen provides a novel neuroendocrine measure to test the relevance of changes in central oestrogen receptor responsiveness in the pathogenesis of puerperal psychosis.

scholarly journals GAS, a new glutamate‐rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function

EMBO Reports ◽  
2008 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Jing Liang ◽  
Hua Zhang ◽  
Yu Zhang ◽  
Ying Zhang ◽  
Yongfeng Shang
Keyword(s):  
Oestrogen Receptor ◽  
Receptor Function

Mechanism of action of somatostatin: An overview of receptor function and studies of the molecular characterization and purification of somatostatin receptor proteins

Metabolism ◽  
1990 ◽  
Vol 39 (9) ◽  
pp. 63-69 ◽  
Author(s):  
Yogesh C. Patel ◽  
Kishore K. Murthy ◽  
Emanuel E. Escher ◽  
Denis Banville ◽  
Joachim Spiess ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Mechanism Of Action ◽  
Somatostatin Receptor ◽  
Receptor Function ◽  
Receptor Proteins

scholarly journals Conjugation of palbociclib with MHI-148 has an increased cytotoxic effect for breast cancer cells and an altered mechanism of action

2021 ◽  
Author(s):  
Euphemia Leung ◽  
Petr Tomek ◽  
Moana Tercel ◽  
Johannes Reynisson ◽  
Thomas In Hyeup Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Endocrine Therapy ◽  
Mechanism Of Action ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Near Infrared ◽  
Triple Negative ◽  
Mammalian Cell Lines

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with oestrogen receptor positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in the highly aggressive triple-negative breast cancer that lacks sensitivity to chemotherapy or endocrine therapy. We hypothesized that conjugation of the near-infrared dye MHI-148 with palbociclib can produce a potential theranostic in triple-negative as well as oestrogen receptor positive breast cancer cells. In our study, the conjugate was found to have enhanced activity in all mammalian cell lines tested in vitro. However, the conjugate was cytotoxic and did not induce G1 cell cycle arrest in breast cancer cells suggesting the mechanism of action differed from the parent compound palbociclib. The study highlights the importance of investigating the mechanism of conjugates of near-infrared dyes to therapeutic compounds as conjugation can potentially result in a change of mechanism or target, with an enhanced cytotoxic effect in this case.

Oestrogen Receptor Function at Classical and Alternative Response Elements

2008 ◽  
pp. 20-32 ◽  
Author(s):  
Peter J. Kushner ◽  
David Agard ◽  
Wei-Jun Feng ◽  
Gabriela Lopez ◽  
Andrew Schiau ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Receptor Function ◽  
Alternative Response ◽  
Response Elements
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