Do Heat-Shock Proteins (Hsps)65-Reactive Lymphocytes in Rheumatoid Arthritis, Hashimoto's Thyroiditis & Systemic Lupus Erythematosus Implicate Hsp65 in autoimmunity?

1996 ◽  
Vol 24 (1) ◽  
pp. 85S-85S
Author(s):  
Clara G. H. Bell
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Lupus Erythematosus ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Systemic Lupus ◽  
Shock Proteins ◽  
Reactive Lymphocytes

Review: Heat Shock Proteins and Systemic Lupus Erythematosus

Lupus ◽  
1991 ◽  
Vol 1 (1) ◽  
pp. 3-8 ◽  
Author(s):  
V. Dhillon ◽  
D. Latchman ◽  
D. Isenberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Shock Proteins

scholarly journals Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.

1988 ◽  
Vol 168 (4) ◽  
pp. 1475-1480 ◽  
Author(s):  
S Minota ◽  
B Cameron ◽  
W J Welch ◽  
J B Winfield
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Lupus Erythematosus ◽  
Solid Phase ◽  
Systemic Lupus ◽  
Hsp70 Family ◽  
Hsp70 Protein ◽  
Sds Page ◽  
Shock Proteins

Serum from patients with systemic lupus erythematosus (SLE) frequently contain IgM and IgG autoantibodies to the constitutively expressed 73-kD/pI 5.5 member of the hsp70 family of heat shock proteins, as determined by one-dimensional (SDS-PAGE) and two-dimensional (IEF/SDS-PAGE) immunoblotting, and by solid-phase SLE Ig immunoprecipitation experiments using hsp70 protein-specific mAbs as probes. Autoantibodies to hsp70 also were detected in a minority of sera from patients with other rheumatic or viral diseases, but not in normal sera. These data may provide additional insight into etiologic and pathophysiologic mechanisms in this and related autoimmune disorders.

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