Antibodies to 65 kDa and 70 kDa heat shock proteins in rheumatoid arthritis and systemic lupus erythematosus

1992 ◽  
Vol 70 (5) ◽  
pp. 295-300 ◽  
Author(s):  
JAI PANCHAPAKESAN ◽  
MALAMA DAGLIS ◽  
PAUL GATENBY
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Shock Proteins

Review: Heat Shock Proteins and Systemic Lupus Erythematosus

Lupus ◽  
1991 ◽  
Vol 1 (1) ◽  
pp. 3-8 ◽  
Author(s):  
V. Dhillon ◽  
D. Latchman ◽  
D. Isenberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Shock Proteins

scholarly journals Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.

1988 ◽  
Vol 168 (4) ◽  
pp. 1475-1480 ◽  
Author(s):  
S Minota ◽  
B Cameron ◽  
W J Welch ◽  
J B Winfield
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Lupus Erythematosus ◽  
Solid Phase ◽  
Systemic Lupus ◽  
Hsp70 Family ◽  
Hsp70 Protein ◽  
Sds Page ◽  
Shock Proteins

Serum from patients with systemic lupus erythematosus (SLE) frequently contain IgM and IgG autoantibodies to the constitutively expressed 73-kD/pI 5.5 member of the hsp70 family of heat shock proteins, as determined by one-dimensional (SDS-PAGE) and two-dimensional (IEF/SDS-PAGE) immunoblotting, and by solid-phase SLE Ig immunoprecipitation experiments using hsp70 protein-specific mAbs as probes. Autoantibodies to hsp70 also were detected in a minority of sera from patients with other rheumatic or viral diseases, but not in normal sera. These data may provide additional insight into etiologic and pathophysiologic mechanisms in this and related autoimmune disorders.

scholarly journals Role of Hsp90 in Systemic Lupus Erythematosus and Its Clinical Relevance

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Hem D. Shukla ◽  
Paula M. Pitha
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Heat Shock ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Heat Shock Protein 90 ◽  
Type I ◽  
Systemic Lupus ◽  
Conformational Regulation ◽  
Shock Proteins ◽  
Hsp 90

Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis of most proteins, rather it participate in structural maturation and conformational regulation of a number of signaling molecules and transcription factors. Hsp90 has been shown to play an important role in antigen presentation, activation of lymphocytes, macrophages, maturation of dendritic cells, and in the enhanceosome mediated induction of inflammation. Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Dysregulated expression of Type I interferonα, activation of B cells and production of autoantibodies are hallmarks of SLE. The enhanced levels of Hsp90 were detected in the serum of SLE patients. The elevated level of Hsp90 in SLE has also been correlated with increased levels of IL-6 and presence of autoantibodies to Hsp90. This suggests that Hsp90 may contribute to the inflammation and disease progression and that targeting of Hsp 90 expression may be a potential treatment of SLE. The pharmacologic inhibition of Hsp90 was successfully applied in mouse models of autoimmune encephalomyelitis and SLE—like autoimmune diseases. Thus targeting Hsp90 may be an effective treatment for SLE, especially if combined with other targeted therapeutic approaches.

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