Glycoproteins of the post-synaptic density: biochemical and immunochemical characterization of PSD-GP180

1992 ◽  
Vol 20 (2) ◽  
pp. 379-382 ◽  
Author(s):  
J. W. Gurd ◽  
I. R. Brown ◽  
N. Bissoon ◽  
S. Cudmore ◽  
B. Ni ◽  
...  
Keyword(s):  
Synaptic Density ◽  
Immunochemical Characterization ◽  
Post Synaptic Density

Characterization of novel post-synaptic-density-enriched glycoproteins gp130 and gp117 with a monoclonal antibody

1990 ◽  
Vol 18 (3) ◽  
pp. 385-388 ◽  
Author(s):  
TIMOTHY WILLMOTT ◽  
CHRISTOPHER P. SELKIRK ◽  
RICHARD B. HAWKES ◽  
PHILIP W. BEESLEY
Keyword(s):  
Monoclonal Antibody ◽  
Synaptic Density ◽  
Post Synaptic Density

Immunochemical characterization of anti-islet cell surface monoclonal antibody from nonobese diabetic mice

Diabetes ◽  
1986 ◽  
Vol 35 (5) ◽  
pp. 517-522 ◽  
Author(s):  
J. Hari ◽  
K. Yokono ◽  
K. Yonezawa ◽  
K. Amano ◽  
S. Yaso ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cell Surface ◽  
Islet Cell ◽  
Diabetic Mice ◽  
Immunochemical Characterization ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

Berberine Alleviates Amyloid-beta Pathogenesis Via Activating LKB1/AMPK Signaling in the Brain of APP/PS1 Transgenic Mice

2019 ◽  
Vol 19 (5) ◽  
pp. 342-348 ◽  
Author(s):  
Zhi-You Cai ◽  
Chuan-Ling Wang ◽  
Tao-Tao Lu ◽  
Wen-Ming Yang
Keyword(s):  
Transgenic Mice ◽  
Western Blotting ◽  
Amyloid Β ◽  
Adenosine Monophosphate ◽  
Camp Response Element Binding ◽  
Enzyme Linked Immunosorbent Assay ◽  
Synaptic Density ◽  
Ampk Signaling ◽  
The Brain ◽  
Post Synaptic Density

Background:Liver kinase B1 (LKB1)/5’-adenosine monophosphate-activated protein kinase (AMPK) signaling, a metabolic checkpoint, plays a neuro-protective role in the pathogenesis of Alzheimer’s disease (AD). Amyloid-β (Aβ) acts as a classical biomarker of AD. The aim of the present study was to explore whether berberine (BBR) activates LKB1/AMPK signaling and ameliorates Aβ pathology.Methods:The Aβ levels were detected using enzyme-linked immunosorbent assay and immunohistochemistry. The following biomarkers were measured by Western blotting: phosphorylated (p-) LKB1 (Ser334 and Thr189), p-AMPK (AMPKα and AMPKβ1), synaptophysin, post-synaptic density protein 95 and p-cAMP-response element binding protein (p-CREB). The glial fibrillary acidic protein (GFAP) was determined using Western blotting and immunohistochemistry.Results:BBR inhibited Aβ expression in the brain of APP/PS1 mice. There was a strong up-regulation of both p-LKB1 (Ser334 and Thr189) and p-AMPK (AMPKα and AMPKβ1) in the brains of APP/PS1 transgenic mice after BBR-treatment (P<0.01). BBR promoted the expression of synaptophysin, post-synaptic density protein 95 and p-CREB(Ser133) in the AD brain, compared with the model mice.Conclusion:BBR alleviates Aβ pathogenesis and rescues synapse damage via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice.

Histomorphological and immunochemical characterization of equine granulosa cell tumors compared to normal ovaries of the mare

2003 ◽  
Vol 19 (6) ◽  
pp. 705-706
Author(s):  
C Ellenberger ◽  
C P Bartmann ◽  
H O Hoppen ◽  
J Kratzsch ◽  
H Aupperle ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Immunochemical Characterization ◽  
Granulosa Cell Tumors

scholarly journals Immunochemical characterization of brain synaptic membrane glutamate-binding proteins.

1990 ◽  
Vol 265 (27) ◽  
pp. 16195-16204 ◽  
Author(s):  
M J Eaton ◽  
J W Chen ◽  
K N Kumar ◽  
Y Cong ◽  
E K Michaelis
Keyword(s):  
Binding Proteins ◽  
Synaptic Membrane ◽  
Immunochemical Characterization ◽  
Glutamate Binding

scholarly journals Myosin IIB Activity and Phosphorylation Status Determines Dendritic Spine and Post-Synaptic Density Morphology

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e24149 ◽  
Author(s):  
Jennifer L. Hodges ◽  
Karen Newell-Litwa ◽  
Hannelore Asmussen ◽  
Miguel Vicente-Manzanares ◽  
Alan Rick Horwitz
Keyword(s):  
Dendritic Spine ◽  
Synaptic Density ◽  
Post Synaptic Density
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