Histomorphological and immunochemical characterization of equine granulosa cell tumors compared to normal ovaries of the mare

2003 ◽  
Vol 19 (6) ◽  
pp. 705-706
Author(s):  
C Ellenberger ◽  
C P Bartmann ◽  
H O Hoppen ◽  
J Kratzsch ◽  
H Aupperle ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Immunochemical Characterization ◽  
Granulosa Cell Tumors

Immunohistochemical Characterization of Primary and Recurrent Adult Granulosa Cell Tumors

2012 ◽  
Vol 31 (1) ◽  
pp. 80-90 ◽  
Author(s):  
Sharon Nofech-Mozes ◽  
Nadia Ismiil ◽  
Valérie Dubé ◽  
Reda S. Saad ◽  
Mahmoud A. Khalifa ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumors

Transvaginal ultrasound in evaluation and follow-up of ovarian granulosa cell tumors

2020 ◽  
Vol 30 (9) ◽  
pp. 1384-1389
Author(s):  
Micaela Petrone ◽  
Alice Bergamini ◽  
Saverio Tateo ◽  
Laura Mariangela Castellano ◽  
Francesca Pella ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Granulosa Cell ◽  
Transvaginal Ultrasound ◽  
Primary Diagnosis ◽  
Ultrasound Images ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell ◽  
Ultrasound Evaluation

ObjectiveUltrasound features of granulosa cell tumors of the ovary are still poorly defined. The aim of this study is to widen current knowledge on the role of sonographic gray scale and pattern recognition in the characterization of these tumors and to compare the ultrasound characteristics of primary diagnosis and recurrences.MethodsTransvaginal ultrasound images of primary diagnosis or recurrences of histologically-confirmed granulosa cell tumors of the ovary were retrospectively retrieved from a dedicated database designed for the collection of clinical and ultrasound data from January 2001 to January 2019. All patients included were treated at San Raffaele and Santa Chiara Hospitals. Women with a concomitant diagnosis of another malignancy other than endometrial carcinoma were excluded from the study. All ultrasound images were described according to International Ovarian Tumor Analysis terminology and examined by experienced ultrasound examiners.ResultsA total of 27 patients were included: 24 with adult and 3 with juvenile ovarian granulosa cell tumors. At primary diagnosis, mean ovarian mass size was 103.8 mm (range 30–200). On ultrasound evaluation at primary diagnosis, 12 patients presented with a multilocular solid lesion (48%), 9 with a solid lesion (36%), and 4 with a multilocular lesion(16%). The echogenicity of the cyst was low level or anechoic, mixed, or hemorrhagic in 56.3%, 31.2%, and 12.5% of cases, respectively. Most tumors (45.1%), including first diagnosis and relapses, had a moderate to high color score on doppler evaluation.ConclusionsOur study showed that sonographic features and pattern recognition of relapses were comparable to those of tumors at primary diagnosis. In order to highlight the importance of transvaginal ultrasound evaluation during follow-up, further studies based on a standardized ultrasound characterization of ovarian masses are recommended.

Abstract GMM-047: GENOMIC CHARACTERIZATION OF ADULT-TYPE GRANULOSA CELL TUMORS: IMPLICATIONS FOR PATHOGENESIS AND TREATMENT OF RECURRENT DISEASE

2019 ◽  
Author(s):  
Jessica A. Pilsworth ◽  
Dawn R. Cochrane ◽  
Samantha Neilson ◽  
Anniina E.M. Färkkilä ◽  
Hugo M. Horlings ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Recurrent Disease ◽  
Adult Type ◽  
Granulosa Cell Tumors ◽  
Genomic Characterization

Immunochemical characterization of anti-islet cell surface monoclonal antibody from nonobese diabetic mice

Diabetes ◽  
1986 ◽  
Vol 35 (5) ◽  
pp. 517-522 ◽  
Author(s):  
J. Hari ◽  
K. Yokono ◽  
K. Yonezawa ◽  
K. Amano ◽  
S. Yaso ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cell Surface ◽  
Islet Cell ◽  
Diabetic Mice ◽  
Immunochemical Characterization ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Immunochemical characterization of brain synaptic membrane glutamate-binding proteins.

1990 ◽  
Vol 265 (27) ◽  
pp. 16195-16204 ◽  
Author(s):  
M J Eaton ◽  
J W Chen ◽  
K N Kumar ◽  
Y Cong ◽  
E K Michaelis
Keyword(s):  
Binding Proteins ◽  
Synaptic Membrane ◽  
Immunochemical Characterization ◽  
Glutamate Binding

scholarly journals Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors

2021 ◽  
Vol 22 (4) ◽  
pp. 2047
Author(s):  
Nina Schmid ◽  
Kim-Gwendolyn Dietrich ◽  
Ignasi Forne ◽  
Alexander Burges ◽  
Magdalena Szymanska ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Granulosa Cell ◽  
Granulosa Cells ◽  
Drug Targets ◽  
Growth Regulation ◽  
Sirtuin 1 ◽  
Ki 67 ◽  
Granulosa Cell Tumors ◽  
Novel Drug

Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells. KGN cells are an established cellular model for the majority of GCTs and were used to explore the role of SIRT1. The SIRT1 activator SRT2104 increased cell proliferation. By contrast, the inhibitor EX527 reduced cell numbers, without inducing apoptosis. These results were supported by the outcome of siRNA-mediated silencing studies. A tissue microarray containing 92 GCTs revealed nuclear and/or cytoplasmic SIRT1 staining in the majority of the samples, and also, SIRT2-7 were detected in most samples. The expression of SIRT1–7 was not correlated with the survival of the patients; however, SIRT3 and SIRT7 expression was significantly correlated with the proliferation marker Ki-67, implying roles in tumor cell proliferation. SIRT3 was identified by a proteomic analysis as the most abundant SIRT in KGN. The results of the siRNA-silencing experiments indicate involvement of SIRT3 in proliferation. Thus, several SIRTs are expressed by GCTs, and SIRT1 and SIRT3 are involved in the growth regulation of KGN. If transferable to GCTs, these SIRTs may represent novel drug targets.

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