THE EFFECT OF CELL VOLUME ON THE RATE OF LACTATE RELEASE FROM RAT SKELETAL MUSCLE

1991 ◽  
Vol 19 (2) ◽  
pp. 198S-198S ◽  
Author(s):  
S.J. Bevan ◽  
M. Parry-Billings ◽  
E. Opara ◽  
E.A. Newsholme
Keyword(s):  
Skeletal Muscle ◽  
Cell Volume ◽  
Rat Skeletal Muscle ◽  
Lactate Release

scholarly journals Effects of changes in cell volume on the rates of glutamine and alanine release from rat skeletal muscle in vitro

1991 ◽  
Vol 276 (2) ◽  
pp. 559-561 ◽  
Author(s):  
M Parry-Billings ◽  
S J Bevan ◽  
E Opara ◽  
E A Newsholme
Keyword(s):  
Skeletal Muscle ◽  
Amino Acids ◽  
Amino Acid ◽  
Cell Volume ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Rat Skeletal Muscle

The effect of changes in cell volume on the rates of release of glutamine and alanine from muscle and on the concentrations of these amino acids in muscle were investigated by using an isolated preparation of rat skeletal muscle incubated in the presence of hypo- and hyper-osmotic media. Changes in cell volume were associated with changes in the rates of release of glutamine and alanine from muscle: incubation in hypo-osmotic medium decreased the rates of release of glutamine and alanine, and incubation in hyperosmotic medium increased these rates. These changes were rapidly reversed by a change in osmoticity of the medium. Despite marked changes in cell volume, the concentrations of these amino acids in muscle were maintained. It is suggested that cell volume may play a role in the regulation of amino acid metabolism in skeletal muscle.

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