Persistence studies on synthetic anabolic agents in the bovine animal

1986 ◽  
Vol 14 (2) ◽  
pp. 447-448 ◽  
Author(s):  
MICHAEL O'KEEFFE
Keyword(s):  
Anabolic Agents ◽  
Bovine Animal

Pharmacological Treatment of Osteoporosis in Elderly People: A Systematic Review and Meta-Analysis

Gerontology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Qin-Yi Wang ◽  
Na Ding ◽  
Yi-He Dong ◽  
Zhang-Xin Wen ◽  
Rong Chen ◽  
...  
Keyword(s):  
Adverse Events ◽  
Elderly Patients ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Anabolic Agents ◽  
Double Blind ◽  
Antiresorptive Agents ◽  
Statistical Heterogeneity ◽  
Post Hoc

<b><i>Background:</i></b> The evidence supporting the use of antiresorptive and anabolic agents for fracture prevention in elderly patients is still inconclusive. Whether it is too late to alter the course of the disease in this age-group has remained uncertain. <b><i>Objectives:</i></b> The objective of this study was to determine the efficacy and safety of antiresorptive and anabolic agents in elderly patients. <b><i>Methods:</i></b> PubMed, Web of Science, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) and post hoc analyses of RCTs reporting efficacy outcomes or adverse events of antiresorptive and anabolic agents in elderly patients. Statistical heterogeneity was assessed with the Cochran <i>Q</i> χ<sup>2</sup> test and <i>I</i><sup>2</sup> statistic. All results were expressed as relative risk (RR) with 95% confidence intervals (CIs). <b><i>Results:</i></b> The meta-analysis included 1 RCT and 11 post hoc analyses of data from 10 double-blind placebo-controlled RCTs. Antiresorptive therapy significantly reduced the pooled incidence of vertebral fractures (RR = 0.43; 95% CI = 0.35–0.53; and <i>p</i> &#x3c; 0.001). It was also associated with lower risk of nonvertebral and hip fractures (RR = 0.84; 95% CI = 0.74–0.96; and <i>p</i> = 0.009 and RR = 0.75; 95% CI = 0.58–0.97; and <i>p</i> = 0.028, respectively). For any adverse events, no difference was observed between antiresorptive agents and placebo groups (RR = 1.01; 95% CI = 1.00–1.02; and <i>p</i> = 0.23). <b><i>Conclusions:</i></b> Both antiresorptive and anabolic agents represented potentially important osteoporosis treatments, showing significant effects on reducing vertebral, nonvertebral, or hip fracture risk, and were well-tolerated by elderly patients. Even in the elderly, maybe it is not too late to alter the course of the disease.

Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers

2007 ◽  
Vol 586 (1-2) ◽  
pp. 73-81 ◽  
Author(s):  
Martina Reiter ◽  
Vanessa M. Walf ◽  
Arne Christians ◽  
Michael W. Pfaffl ◽  
Heinrich H.D. Meyer
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Anabolic Agents

scholarly journals Purification of urine samples to improve detection limit of anabolic agents

2007 ◽  
Vol 39 (1) ◽  
pp. 39
Author(s):  
A Beotra ◽  
S Jain ◽  
T Kaur ◽  
Ranjit Lal ◽  
MadhusudhanaI Reddy
Keyword(s):  
Detection Limit ◽  
Urine Samples ◽  
Anabolic Agents ◽  
Improve Detection Limit

Tissue specific differences in insulin receptor characteristics in the mature bovine animal

1997 ◽  
Vol 1997 ◽  
pp. 51-51
Author(s):  
P.D. McGrattan ◽  
A.R.G. Wylie ◽  
R.W.J. Steen ◽  
J. Nelson
Keyword(s):  
Insulin Receptor ◽  
Biological Effects ◽  
Insulin Receptors ◽  
Plasma Insulin Concentration ◽  
Protein Deposition ◽  
Wheatgerm Agglutinin ◽  
Receptor Number ◽  
Tracer Amount ◽  
Triton X ◽  
Bovine Animal

Insulin is believed to play a key role in the partitioning of nutrients towards fat and protein deposition. The biological effects of insulin are a function of plasma insulin concentration, insulin-receptor concentration and the affinity of the receptor. The number and affinity of insulin receptors on adipocytes differs between genetically lean and obese pigs (Camara and Mourot, 1996) while receptor number, but not affinity, was shown to differ in a variety of bovine muscles (Boge et al., 1995). The objective of the current work was to determine if insulin receptor affinity and number vary between the principal target tissues (i.e. liver, muscle and adipose tissue) in the bovine animal.Five Charolais-cross steers were offered grass silage ad libitum from 18 months of age until slaughter, at 701± 22.9 kg, at a commercial abattoir. Samples of liver [L], of two skeletal muscles [Ml, M3] and of subcutaneous [S], omental [0]and renal [R] fats were taken as soon as possible after slaughter (typically <30min for L, M3, S and O and <45min for Mland R), wrapped and snap frozen in liquid nitrogen prior to storage at -70 °. Insulin receptors were partially purified by solubilising tissues in 1% Triton X-100 for 24 hours at 4 °C followed by centrifugation (100000 x g, lh, 4°) and affinity chromatography of the supernatants on 0.5 ml wheatgerm agglutinin Sepharose 6MB columns. Bound receptors were eluted from the column with 0.3M N-acetyl-D-glucosamine. Receptor binding was assessed using a tracer amount of A-14 125I-insulin (∼35 pM) and increasing concentrations of unlabelled insulin (0-10 μM) in a total volume of 150 μl of pH 7.4 buffer as described by Magri et al (1990).

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