Adenylyl Cyclase-Activating Anabolic Agents: Parathyroid Hormone and Prostaglandins E

2013 ◽  
pp. 123-164
Keyword(s):  
Parathyroid Hormone ◽  
Adenylyl Cyclase ◽  
Anabolic Agents ◽  
Prostaglandins E

scholarly journals Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone

1991 ◽  
Vol 266 (3) ◽  
pp. 1997-2004
Author(s):  
F E Cohen ◽  
G J Strewler ◽  
M S Bradley ◽  
M Carlquist ◽  
M Nilsson ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Adenylyl Cyclase ◽  
Receptor Binding

Effects of parathyroid hormone and agonists of the adenylyl cyclase and protein kinase C pathways on bone cell proliferation

Bone ◽  
1996 ◽  
Vol 18 (1) ◽  
pp. 59-65 ◽  
Author(s):  
M. Sabatini ◽  
C. Lesur ◽  
M. Pacherie ◽  
P. Pastoureau ◽  
N. Kucharczyk ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Adenylyl Cyclase ◽  
Bone Cell ◽  
Kinase C ◽  
Bone Cell Proliferation

Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C

1994 ◽  
Vol 266 (6) ◽  
pp. E897-E904 ◽  
Author(s):  
A. M. Kitten ◽  
T. K. Hymer ◽  
M. S. Katz
Keyword(s):  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Adenylyl Cyclase ◽  
Catalytic Subunit ◽  
Mrna Levels ◽  
Binding Studies ◽  
Kinase C ◽  
Bidirectional Modulation ◽  
Umr 106

The temporal pattern with which phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), modulates parathyroid hormone (PTH)-responsive adenylyl cyclase (AC) was evaluated in a clonal osteoblast-like cell line (UMR-106). Brief (< or = 1 h) exposure of UMR-106 cells to PMA enhanced PTH stimulation of AC, whereas more prolonged PMA treatment decreased the PTH response, with maximum inhibition occurring at < or = 6 h. PMA treatment also resulted in initial activation followed by downregulation of PKC. Exposure of cells to 1,2-dioctanoyl-sn-glycerol, which activated but did not downregulate PKC, resulted in bidirectional modulation of PTH-responsive AC identical to that produced by PMA. Prolonged PMA exposure decreased PTH receptor number, as determined by radioligand binding studies, and reduced PTH receptor mRNA levels, assessed by Northern blot analysis. Forskolin activation of the catalytic subunit of AC was also decreased after prolonged PMA treatment. The results suggest that activation of PKC sequentially stimulates and then inhibits PTH responsiveness. Inhibition of the PTH response occurs by PKC actions exerted on the PTH receptor and the AC catalytic subunit.

scholarly journals Sclerostin

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Stuart L. Silverman
Keyword(s):  
Monoclonal Antibody ◽  
Parathyroid Hormone ◽  
Potent Inhibitor ◽  
Anabolic Agents ◽  
New Era ◽  
Clinical Benefits

The striking clinical benefits of intermittent parathyroid hormone in osteoporosis have begun a new era of skeletal anabolic agents. One potential new agent is monoclonal antibody to sclerostin, a potent inhibitor of osteoblastogenesis.

Role of 5′-Guanylylimidodiphosphate in the Activation of Adenylyl Cyclase by Parathyroid Hormone

1976 ◽  
Vol 3 (6) ◽  
pp. 407-419 ◽  
Author(s):  
David Goltzman ◽  
Edward N. Callahan ◽  
Geoffrey W. Tregear ◽  
John T. Potts
Keyword(s):  
Parathyroid Hormone ◽  
Adenylyl Cyclase
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