Oxidative function of brown adipose tissue of lean and obese Zucker rats

1983 ◽  
Vol 11 (6) ◽  
pp. 726-727
Author(s):  
JOHN M. FLETCHER ◽  
PAUL HAGGARTY ◽  
FINELLA FORSYTH
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Zucker Rats ◽  
Brown Adipose ◽  
Obese Zucker Rats ◽  
Oxidative Function

scholarly journals α1- and β-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold-acclimation, sucrose feeding and adrenalectomy

1988 ◽  
Vol 249 (3) ◽  
pp. 831-838 ◽  
Author(s):  
A Raasmaja ◽  
D A York
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Acclimation ◽  
Adrenergic Receptors ◽  
Zucker Rats ◽  
Receptor Density ◽  
Beta Adrenergic Receptors ◽  
Brown Adipose ◽  
Sucrose Feeding ◽  
Obese Zucker Rats

1. The populations of alpha 1- and beta-adrenergic receptors in brown adipose tissue (BAT) of genetically obese Zucker rats (fa/fa) were studied with [3H]prazosin and [3H]CGP-12177 respectively. 2. The density of alpha 1-adrenergic receptors in BAT was significantly lower in obese than in lean Zucker rats, both at 2-4 months of age and at 6 weeks of age. The density of beta-adrenergic receptors was identical in BAT of lean and obese 6-week-old Zucker rats. 3. Cold-acclimation increased the alpha 1-receptor density significantly in BAT of both lean and obese Zucker rats, and the number of beta-receptors was also somewhat increased. 4. Sucrose feeding did not affect the density of alpha 1-receptors in BAT of lean or obese Zucker rats, but it increased beta-receptor density. 5. Adrenalectomy restored the density of alpha 1-adrenergic receptors in BAT of obese Zucker rats to the value observed in lean rats. 6. It is concluded that there is a direct correlation between alpha 1-receptor density and tissue recruitment, and that alpha 1-receptor density is thus positively correlated with sympathetic activity. beta-Receptor density is apparently better correlated with feeding conditions.

Metformin and brown adipose tissue thermogenetic activity in genetically obese Zucker rats

1993 ◽  
Vol 246 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Juha Rouru ◽  
Kaisa Isaksson ◽  
Eriika Santti ◽  
Risto Huupponen ◽  
Markku Koulu
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Zucker Rats ◽  
Brown Adipose ◽  
Obese Zucker Rats

scholarly journals The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rats

1982 ◽  
Vol 208 (3) ◽  
pp. 819-822 ◽  
Author(s):  
Susan Holt ◽  
David A. York
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Binding Sites ◽  
Zucker Rats ◽  
Lean Control ◽  
Brown Adipose ◽  
Obese Rats ◽  
Number Of Binding Sites ◽  
Obese Zucker Rats

GDP binding to brown-adipose-tissue mitochondria of young obese Zucker rats (fa/fa) was significantly lower than in lean control rats, as a result of a decrease in the number of binding sites. Adrenalectomy of fa/fa rats restored GDP binding to control values. Corticosterone replacement suppressed GDP binding in adrenalectomized obese rats.

scholarly journals The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa)

1983 ◽  
Vol 214 (1) ◽  
pp. 215-223 ◽  
Author(s):  
S Holt ◽  
D A York ◽  
J T R Fitzsimons
Keyword(s):  
Adipose Tissue ◽  
Food Intake ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Zucker Rats ◽  
Brown Adipose ◽  
Obese Rats ◽  
Brown Adipose Tissue Thermogenesis ◽  
Obese Zucker Rats ◽  
Normal Increase

GDP binding to brown-adipose-tissue mitochondria was decreased in obese Zucker rats. Adrenalectomy restored both GDP binding and serum tri-iodothyronine of obese rats to values observed in lean rats. The effects of adrenalectomy on GDP binding and serum tri-iodothyronine were reversed by corticosterone. Decreasing food intake had no effect on brown-adipose-tissue GDP binding in obese rats. Young (5-week-old) obese rats showed a normal increase in brown-adipose-tissue mitochondrial GDP binding after housing at 4 degrees C for 7 days, but this response was attenuated in 10-week-old obese rats. Overfeeding with sucrose increased brown-adipose-tissue thermogenesis in lean, but not in obese, rats. After adrenalectomy, overfeeding with sucrose enhanced brown-adipose-tissue mitochondrial GDP binding in obese rats.

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