SYNTHESIS OF PYRUVATE KINASE IN DEVELOPING RAT LIVER

1981 ◽  
Vol 9 (2) ◽  
pp. 255P-255P
Author(s):  
S. C. Wong ◽  
S. W. N. Wu ◽  
D. C. Y. Yeung
Keyword(s):  
Pyruvate Kinase ◽  
Rat Liver ◽  
Developing Rat

scholarly journals Comparison of the properties of two forms of pyruvate kinase in rat liver and determination of their separate activities during development

1972 ◽  
Vol 127 (4) ◽  
pp. 721-731 ◽  
Author(s):  
Marshall C. Middleton ◽  
Deryck G. Walker
Keyword(s):  
Skeletal Muscle ◽  
Pyruvate Kinase ◽  
Rat Liver ◽  
Developmental Period ◽  
Late Gestation ◽  
Kinetic Properties ◽  
Foetal Rat ◽  
Neonatal Liver ◽  
Developing Rat

1. Two forms of hepatic pyruvate kinase, designated type L and type M, were distinguished on the basis of kinetic, chromatographic, electrophoretic and immunological criteria. They were partially purified and their properties compared with each other and with the purified enzyme from skeletal muscle. 2. In contrast with type L, the type M enzyme showed no marked evidence of co-operative interactions with phosphoenolpyruvate and was not stimulated by fructose diphosphate. 3. The activity profiles of type L and type M enzymes were determined in developing rat liver by utilizing differences in the kinetic properties of the two forms. The high activity of type M enzyme in the early foetal rat decreased in late gestation and immediately after birth to reach a low value, which remained essentially constant for the remainder of the developmental period. The activity of type L enzyme, in contrast, was low in the early foetal and neonatal liver but increased markedly at the onset of weaning. 4. Possible roles of the two forms of hepatic pyruvate kinase in the control of glycolysis and gluconeogenesis are discussed.

Enzymes of Glycerol Metabolism in Developing Rat Liver and Kidney

Enzyme ◽  
1974 ◽  
Vol 17 (3) ◽  
pp. 168-178 ◽  
Author(s):  
Helen B. Burch ◽  
Oliver H. Lowry ◽  
Lucile M. Delaney
Keyword(s):  
Rat Liver ◽  
Glycerol Metabolism ◽  
Liver And Kidney ◽  
Developing Rat
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