Effect of Electrical Stimulation of the Autonomic Nerve Supply on the Concentration of Guanosine 3′: 5′-Cyclic Monophosphate and the Activity of Guanylate Cyclase in Rat Salivary Glands and their Relationship to the Induction of Growth

1977 ◽  
Vol 5 (4) ◽  
pp. 1081-1083 ◽  
Author(s):  
JOHN P. DURHAM ◽  
FRED R. BUTCHER ◽  
THOMAS C. MUIR ◽  
DAVID TEMPLETON
Keyword(s):  
Electrical Stimulation ◽  
Salivary Glands ◽  
Guanylate Cyclase ◽  
Autonomic Nerve ◽  
Nerve Supply ◽  
Cyclic Monophosphate ◽  
Rat Salivary Glands ◽  
Stimulation Of

Increased polyamine formation in rat salivary glands by stimulation of their autonomic nerve supply

1985 ◽  
Vol 30 (11-12) ◽  
pp. 773-775 ◽  
Author(s):  
J. Ekström ◽  
B. Månsson ◽  
B.-O. Nilsson ◽  
Elsa Rosengren ◽  
G. Tobin
Keyword(s):  
Salivary Glands ◽  
Autonomic Nerve ◽  
Nerve Supply ◽  
Rat Salivary Glands ◽  
Stimulation Of

EXPERIMENTS ON ATROPINE-RESISTANT VASODILATATION IN SALIVARY GLANDS

1963 ◽  
Vol 41 (2) ◽  
pp. 519-524 ◽  
Author(s):  
B. C. R. Strömblad ◽  
Peter E. Dresel
Keyword(s):  
Salivary Glands ◽  
Blocking Effect ◽  
Nerve Supply ◽  
Parotid Glands ◽  
Cholinergic Nerves ◽  
Parasympathetic Nerve ◽  
Ganglionic Transmission ◽  
Stimulation Of

Vasodilatation induced by stimulation of the parasympathetic nerve supply to the submaxillary and the parotid glands has long been known to be resistant to the blocking effect of atropine. We have found that dichloroisoproterenol does not block this vasodilatation, that d-tubocurarine blocks it by interfering with ganglionic transmission, and that a hemicholinium, HC-3, blocks it gradually under conditions in which interference with ganglionic transmission is excluded. It is concluded that the mechanism of vasodilatation includes the action of cholinergic nerves.

Effects of oxytocin and methacholine on cyclic nucleotide levels of rabbit myometrium

1980 ◽  
Vol 58 (3) ◽  
pp. 243-248 ◽  
Author(s):  
N. Schlageter ◽  
R. A. Janis ◽  
R. T. Gualtieri ◽  
O. Hechter
Keyword(s):  
Guanylate Cyclase ◽  
Cyclic Nucleotide ◽  
Phosphodiesterase Inhibitor ◽  
Isometric Tension ◽  
Free Solution ◽  
Cyclic Monophosphate ◽  
Opposing Effects ◽  
Camp Levels ◽  
Camp And Cgmp ◽  
Stimulation Of

The effects of oxytocin and methacholine on cyclic nucleotide levels in estrogen-primed rabbit myometrium were studied in the presence and absence of 1-methyl-3-isobutyl xanthine (MIX), a phosphodiesterase inhibitor. In the absence of MIX, methacholine increased guanosine 3′,5′-cyclic monophosphate (cGMP) levels at a time when contraction was decreasing, but had no influence on adenosine 3′,5′-cyclic monophosphate (cAMP) levels. In contrast, oxytocin did not elevate cGMP, but rapidly increased cAMP levels. MIX (1 mM) increased both cAMP and cGMP levels. Oxytocin or methacholine further increased cGMP, indicating activation of guanylate cyclase. Oxytocin- but not methacholine-induced stimulation of guanylate cyclase was abolished in Ca2+-free solution. Oxytocin increased cAMP over the levels produced by MIX alone, whereas methacholine decreased cAMP below the MIX control values; these effects were insensitive to indomethacin. Tissue levels of cGMP and cAMP did not directly correlate with isometric tension. The results also indicate that both oxytocin and methacholine stimulate guanylate cyclase but have opposing effects on adenylate cyclase of rabbit myometrium.

GRP-producing nerves control antral somatostatin and gastrin secretion in pigs

1987 ◽  
Vol 253 (6) ◽  
pp. G767-G774 ◽  
Author(s):  
J. J. Holst ◽  
S. Knuhtsen ◽  
C. Orskov ◽  
T. Skak-Nielsen ◽  
S. S. Poulsen ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Substance P ◽  
Nerve Fibers ◽  
Antral Mucosa ◽  
Nerve Supply ◽  
Vagus Nerves ◽  
Vagus Stimulation ◽  
Gastrin Secretion ◽  
Stimulation Of

By immunohistochemistry, nerve fibers containing gastrin-releasing polypeptide (GRP)-like immunoreactivity were identified close to the somatostatin (SS)-producing cells of the gastric antral mucosa. We, therefore, studied the possible role of GRP in the control of antral SS secretion by use of isolated perfused pig antrum with intact vagus nerve supply. Electrical stimulation of the vagus nerves at 4 Hz increased the antral release of GRP up to 10-fold and increased SS output 2- to 3-fold. Atropine at 10(-6) M had no effect on these responses. Intra-arterial GRP increased SS secretion significantly at 10(-10) M and eightfold at 10(-8) M, whereas gastrin secretion was stimulated significantly at 10(-11) M and maximally at 10(-10) M and inhibited at 10(-8) M. Preperfusion with a GRP antagonist ([D-Arg1,D-Pro2,D-Trp7,9,Leu11]substance P) or Fab fragments of antibodies against GRP abolished the effects of vagus stimulation on gastrin and somatostatin output. Gastrin in concentrations up to 10(-7) M was without effect on SS secretion. We conclude that electrical stimulation of the vagus nerves increases antral SS gastrin secretion and that GRP is a likely transmitter.

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