Effects of 5α-Reduced Androgens on Preputial-Gland Size and Lipogenic Activity

1976 ◽  
Vol 4 (4) ◽  
pp. 795-797 ◽  
Author(s):  
PAUL E. BOWDEN ◽  
DAVID MEDDIS ◽  
MARY F. COOPER ◽  
ANTHONY J. THODY ◽  
SAM SHUSTER
1976 ◽  
Vol 71 (3) ◽  
pp. 279-288 ◽  
Author(s):  
A. J. THODY ◽  
MARY F. COOPER ◽  
P. E. BOWDEN ◽  
D. MEDDIS ◽  
S. SHUSTER

SUMMARY The effects of α-MSH and testosterone propionate on sebum secretion, sebaceous gland volume, dermal lipogenesis, and preputial gland weight and lipogenesis were examined in hypophysectomized rats. Hypophysectomy reduced sebum secretion, sebaceous and preputial gland size, and dermal and preputial gland lipogenesis. The greatest effects were seen on the biosynthesis of wax esters and squalene. Testosterone propionate (TP) increased sebum secretion, sebaceous gland volume and preputial gland weight and lipogenic activity, but had no significant effect on the pattern of lipid labelling. α-MSH had no effect on sebaceous or preputial gland size, but increased sebum secretion and dermal lipogenesis, especially wax ester biosynthesis. When given together TP and α-MSH had a synergistic effect on sebum secretion and on dermal and preputial gland lipogenesis, and the pattern of lipid labelling was shifted towards normal. TP and α-MSH also showed synergism in increasing preputial gland weight, but together they had no greater effect on sebaceous gland volume than that achieved with TP alone. These results suggest that TP and α-MSH have different actions on the sebaceous glands with α-MSH acting predominantly on lipogenesis and TP on cellular proliferation and turnover leading to an increase in gland size. Preputial glands differ from cutaneous sebaceous glands in their response to α-MSH and androgen which could be a reflection of their more specialized function.


2007 ◽  
Vol 177 (4S) ◽  
pp. 1-2
Author(s):  
Adam W. Levinson ◽  
Richard E. Link ◽  
Lynda Z. Mettee ◽  
Soroush Rais-Bahrami ◽  
Devesh Agarwal ◽  
...  

1986 ◽  
Vol 83 (19) ◽  
pp. 7292-7296 ◽  
Author(s):  
Y. Nishimura ◽  
M. G. Rosenfeld ◽  
G. Kreibich ◽  
U. Gubler ◽  
D. D. Sabatini ◽  
...  

2000 ◽  
Vol 76 (5) ◽  
pp. 73-75
Author(s):  
Soundarapandian KANNAN ◽  
Govindaraju ARCHUNAN
Keyword(s):  

2006 ◽  
Vol 60 (2) ◽  
pp. 62-65
Author(s):  
Masaaki Inaba ◽  
Senji Okuno ◽  
Hidenori Chou ◽  
Yasuo Imanishi ◽  
Misako Ueda ◽  
...  

2018 ◽  
Vol 39 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Nicolette Nabukeera-Barungi ◽  
Benedikte Grenov ◽  
Henrik Friis ◽  
Betty Lanyero ◽  
Hanifa Namusoke ◽  
...  

1987 ◽  
Vol 24 (4) ◽  
pp. 302-307 ◽  
Author(s):  
S. Kennedy ◽  
H. J. Ball

One mammary gland of each of nine primum partum suckling ewes was inoculated with ureaplasma 8 weeks post-partum. Infected glands were swollen, hot, and painful from 16 hours post-infection. Subsequently there was agalactia and reduction in gland size. Histopathologic and ultrastructural examination indicated that the acute phase of the induced mastitis was characterized by necrosis of secretory epithelium with a neutrophil, eosinophil, and macrophage response. Subsequently there was lymphoid infiltration, acinar involution, and fibrosis. This report confirms the pathogenicity of ureaplasma for the ovine mammary gland, and is the first description of the pathologic features of ureaplasmal mastitis in sheep.


Sign in / Sign up

Export Citation Format

Share Document